Response: Re: Effect of γ-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene [2]

Journal of the National Cancer Institute

Volumn 98, Issue 10, 2006, Pages 718-720

  Menendez, Javier A ^a   Lupu, Ruth ^b,c  

^a HOSPITAL JOSEP TRUETA   (Spain)

^b EVANSTON NORTHWESTERN HEALTHCARE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BEZAFIBRATE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FATTY ACID SYNTHASE; GAMMA LINOLENIC ACID; OLEIC ACID; TRANSCRIPTION FACTOR PEA3; TRASTUZUMAB; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

ANTINEOPLASTIC ACTIVITY; BINDING SITE; BREAST CANCER; COMPLEX FORMATION; DRUG DNA BINDING; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME INHIBITION; GENE AMPLIFICATION; GENE DELETION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; LETTER; PRIORITY JOURNAL; PROMOTER REGION; APOPTOSIS; DRUG EFFECT; ENZYMOLOGY; GENETICS; NEOPLASM; NOTE; PROTO ONCOGENE; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DRUG SYNERGISM; GAMMA-LINOLENIC ACID; GENES, ERBB-2; HUMANS; NEOPLASMS; TRANSCRIPTION, GENETIC;

EID: 33744817397     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djj203     Document Type: Letter

References (7)

1. Menendez JA, Vellon L, Colomer R, Lupu R. Effect of γ-lipogenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. J Natl Cancer Inst 2005;97:1611-5.
2. Menendez JA, Vellon L, Colomer R, Lupu R. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her-2/neu oncogene amplification. Ann Oncol 2005;16:359-71.
3. Menendez JA, Papadimitropoulou A, Vellon L, Colomer R, Lupu R. A genomic explanation connecting "Mediterranean diet," olive oil and cancer: oleic acid, the main monounsaturated fatty acid of olive oil, induces formation of inhibitory "PEA3 transcription factor-PEA3 DNA binding site" complexes at the Her-2/neu (erbB-2) oncogene promoter in breast, ovarian and stomach cancer cells. Eur J Cancer 2006; Epub ahead of print (DOI: 10.1016/j.ejca.2005.10.1016).
4. Menendez JA, Ropero S, Lupu R, Colomer R. Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells. Ann Oncol 2004;15: 1719-21.
5. Menendez JA, Vellon L, Mehmi I, Oza BP, Ropero S, Colomer R, Lupu R. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA 2004;101:10715-20.
6. Menendez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R. Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal α-linolenic and γ-linolenic fatty acids: A novel mechanism by which dietary fat can alter mammary tumorigenesis. Int J Oncol 2004;24: 1369-83.
7. Zhang D, Tai LK, Wong LL, Chiu LL, Sethi SK, Koay ES. Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics 2005;4:1686-96.