Adenoviral gene transfer of a mutant surfactant enzyme ameliorates pseudomonas-induced lung injury

Gene Therapy

Volumn 13, Issue 12, 2006, Pages 974-985

  Zhou, J ^a   Wu, Y ^a   Henderson, F ^a   McCoy, D M ^a   Salome, R G ^a   McGowan, S E ^a   Mallampalli, Rama K ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Acute lung injury; Adenovirus; Cytidylyltransferase; Gene transfer; Phosphatidylcholine; Surfactant

Indexed keywords

ADENOVIRUS VECTOR; CALPAIN; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; LACTATE DEHYDROGENASE; LUNG SURFACTANT; PSEUDOMONAS EXOTOXIN;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME DEGRADATION; GENE CONSTRUCT; GENE EXPRESSION; GENE TRANSFER; GENETIC CODE; GRAM NEGATIVE SEPSIS; IMMUNOBLOTTING; LUNG ALVEOLUS SURFACE TENSION; LUNG COMPLIANCE; LUNG FUNCTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VIRAL GENE DELIVERY SYSTEM;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; ACUTE DISEASE; ADENOVIRIDAE; ANIMALS; CALCIUM-BINDING PROTEINS; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; GENE THERAPY; GENETIC VECTORS; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED C57BL; PSEUDOMONAS INFECTIONS; PULMONARY SURFACTANTS; TRANSDUCTION, GENETIC;

BACTERIA (MICROORGANISMS); HUMAN ADENOVIRUS TYPE 5; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 33744816504     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/sj.gt.3302746     Document Type: Article

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