Neutrophil elastase in colitis: More than a marker of disease activity?

Journal of Gastroenterology

Volumn 41, Issue 4, 2006, Pages 395-396

  Hokari, Ryota ^a   Miura, Soichiro ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 1 ANTITRYPSIN; DEXTRAN SULFATE; EPIDERMAL GROWTH FACTOR RECEPTOR; LEUKOCYTE ELASTASE; LEUKOCYTE ELASTASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN; ONO 6818; PHOSPHATIDYLSERINE; PREDNISOLONE; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 2; SIVELESTAT; STEROID; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

CELL PROTECTION; COLITIS; CYTOKINE PRODUCTION; DISEASE ACTIVITY; DISEASE COURSE; EDITORIAL; ENTERITIS; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; IN VITRO STUDY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

ANIMALS; BIOLOGICAL MARKERS; COLITIS; CRICETINAE; DEXTRAN SULFATE; HUMANS; LEUKOCYTE ELASTASE; MICE; SEVERITY OF ILLNESS INDEX;

EID: 33744807502     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-006-1808-z     Document Type: Editorial

References (16)

1. RW Vandivier VA Fadok PR Hoffmann DL Bratton C Penvari KK Brown et al. 2002 Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis J Clin Invest 109 661-70 11877474 1:CAS:528:DC%2BD38XitVeqtb8%3D 10.1172/ JCI200213572
2. A Uehara K Muramoto H Takada S Sugawara 2003 Neutrophil serine proteinases activate human nonepithelial cells to produce inflammatory cytokines through protease-activated receptor 2 J Immunol 170 5690-6 12759451 1:CAS:528:DC%2BD3sXjvVynurY%3D
3. JM Devaney CM Greene CC Taggart TP Carroll SJ O'Neill NG McElvaney 2003 Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4 FEBS Lett 544 129-32 12782302 1:CAS:528:DC%2BD3sXktFWlur0%3D 10.1016/ S0014-5793(03)00482-4
4. K Kohri IF Ueki JA Nadel 2002 Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation Am J Physiol Lung Cell Mol Physiol 283 L531-40 12169572 1:CAS:528:DC%2BD38XntFOmtLs%3D
5. SJ DiCamillo I Carreras MV Panchenko PJ Stone MA Nugent JA Foster 2002 Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts J Biol Chem 277 18938-46 11889128 1:CAS:528:DC%2BD38XktFChtrc%3D 10.1074/jbc.M200243200
6. Dicamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, et al. Neutrophil elastase initiated EGFR/MEK/ERK signaling counteracts the stabilizing effect of autocrine TGF-β on tropoelastin mRNA in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2006 (in press)
7. I Gouni-Berthold B Baumeister E Wegel HK Berthold H Vetter C Schmidt 1999 Neutrophil-elastase in chronic inflammatory bowel disease: A marker of disease activity? Hepatogastroenterology 46 2315-20 10521989 1:STN:280:DyaK1MvltFClsQ%3D%3D
8. K Sugi O Saitoh I Hirata K Katsu 1996 Fecal lactoferrin as a marker for disease activity in inflammatory bowel disease: Comparison with other neutrophil-derived proteins Am J Gastroenterol 91 927-34 8633583 1:CAS:528:DyaK28XjsFWjsb0%3D
9. Y Kuno K Ina T Nishiwaki T Tsuzuki M Shimada A Imada 2002 Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis J Gastroenterol 37 Suppl 14 22-32 12572862
10. Y Hirota M Suzuki K Yamaguchi T Fujita N Katsube 2004 Colonic ulceration and increase of neutrophil elastase activity in the acetic acid-induced colitis model in Syrian hamsters J Vet Med Sci 66 417-22 15133272 1:CAS:528:DC%2BD2cXksVWjt7o%3D 10.1292/jvms.66.417
11. Y Hirota M Suzuki K Yamaguchi T Fujita N Katsube 2004 Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters J Vet Med Sci 66 1223-8 15528853 1:CAS:528:DC%2BD2cXhtVKju7nE 10.1292/jvms.66.1223
12. S Suzuki F Gejyo T Kuroda JJ Kazama N Imai H Kimura 1998 Effects of a novel elastase inhibitor, ONO-5046, on nephrotoxic serum nephritis in rats Kidney Int 53 1201-8 9573534 1:CAS:528:DyaK1cXjtV2iu7Y%3D 10.1046/ j.1523-1755.1998.00872.x
13. K Kakimoto A Matsukawa M Yoshinaga H Nakamura 1995 Suppressive effect of a neutrophil elastase inhibitor on the development of collagen-induced arthritis Cell Immunol 165 26-32 7671322 1:CAS:528:DyaK2MXot1Wgsb8%3D 10.1006/cimm.1995.1183
14. Y Morohoshi K Matsuoka H Chinen N Kamada T Sato T Hisamatsu 2006 Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis J Gastroenterology 41 318-24 10.1007/s00535-005-1768-8
15. O Saitoh K Sugi R Matsuse K Uchida H Matsumoto K Nakagawa 1995 The forms and the levels of fecal PMN-elastase in patients with colorectal diseases Am J Gastroenterol 90 388-93 7872275 1:STN:280:ByqC2sjhtFM%3D
16. EO Adeyemi VS Chadwick HJ Hodgson 1990 The effect of some anti-inflammatory agents on elastase release from neutrophils in-vitro J Pharm Pharmacol 42 487-90 1980289 1:CAS:528:DyaK3MXhslamuw%3D%3D