Neutrophil-elastase in chronic inflammatory bowel disease: A marker of disease activity?

Hepato-Gastroenterology

Volumn 46, Issue 28, 1999, Pages 2315-2320

  Gouni Berthold, Ioanna ^a   Baumeister, B ^b   Wegel, E ^b   Berthold, H K ^b   Vetter, H ^b   Schmidt, C ^b  

^a UNIVERSITY OF BONN   (Germany)

^b NONE

Author keywords

Crohn's disease; Diagnostic measures; Disease activity marker; Gastroenterology; Human; Inflammatory bowel disease; Neutrophil elastase; Ulcerative colitis

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; LEUKOCYTE ELASTASE;

ADULT; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; ENZYME BLOOD LEVEL; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REMISSION; ULCERATIVE COLITIS;

ADULT; BIOLOGICAL MARKERS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; CHRONIC DISEASE; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; HUMANS; LEUKOCYTE ELASTASE; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY;

EID: 0032854148     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Borregaard N: The human neutrophil. Function and dysfunction. Eur J Haematol 1988; 41:401-413.
2. Jochum M, Duswald KH, Neumann S, Witte J, Fritz H: Proteinases and their inhibitors in septicemia - basic concepts and clinical implications. In: Hörl WA, Heidland A (Eds.) Proteases. Potential role in health and disease. New York, London: Plenum Press 1984; pp. 391-404.
3. Schweinsfurth H, Zöller E, Schmidt M, Brugger E, Thiel H: Veränderungen der Leukozytenelastase beim Asthma und Bronchialkarzinom. Kiln Wschr 1985; 63:40.
4. Malchow H, Ewe K, Brandes W, Goebell H, Ehms H, Sommer H, Jeschinsky H: European Cooperative Crohn's Disease Study (ECCDS). Results of drug treatment. Gastroenterol 1984; 86:249-266.
5. Best WR, Bectel JM, Kern F: Development of a Crohn's disease activity index. Gastroenterol 1976; 70:439-444.
6. Van Hees PAM, Van Elteren PH, Van Liehr HJJ, Van Tongeren JHM: An index of inflammatory activity in patients with Crohn's disease. Gut 1980; 21:279-285.
7. Rachmilewitz D: Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. Br Med J 1989; 298:82-86.
8. Hafner G, Dreher M, Lütgehaus M, Ehrental W, Heubner A, Swats H, Prellwitz W: Determination of human granulocyte elastase by the immunoactivation method on the Hitachi 717 automated analyser. Eur J Clin Chem Clin Biochem 1991; 29:179-183.
9. Adeyemi EO, Hodgson HJF: Faecal elastase reflects disease activity in active ulcerative colitis. Scand J Gastroenterol 1992; 27:139-142.
10. Bayer PM, Lanschützer H, Knoth E, Klech H, Kummer F: Elastase-Inhibitor-Komplexe in der Differentialdiagnose von Pleuraergüssen. Lab Med 1983; 7:106.
11. Lang H, Heubner A, Dreher M: Elastase. Der entscheidende Marker in der Entzündungsdiagnostik. GIT-Labormedizin 1989; 3:77-81.
12. Fischbach W, Becker J, Mössner J, Ohlenmüller H, Koch W, Börner W: Leucocyte elastase in chronic inflammatory bowel disease: a marker of inflammatory activity? Digestion 1987; 37:88-95.
13. Gomes H, Du Boulay C, Smith CL, Holdstock G: Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease. Gut 1986; 27:92-95.
14. Prantera C, Luzi C, Olivotto P, Levenstein S, Cerro P, Fanucci A: Relationship between clinical and laboratory parameters and length of lesion in Crohn's disease of small bowel. Dig Dis Sci 1984; 29:1093-1097.
15. Andus T, Gross V, Caesar I, Krumm D, Hosp J, Gerok W, Schoelmerich J: PMN - elastase in assessment of patients with inflammatory disease. Dig Dis Sci 1993; 38:1638-1644.
16. Adeyemi EO, Neumann S, Chadwick VS, Hodgson HFJ, Pepys MB: Circulating human leucocyte elastase in patients with inflammatory bowel disease. Gut 1985; 26:1306-1311.