Association of Grb-2 and PI3K p85 with phosphotyrosile peptides derived from BTLA

Biochemical and Biophysical Research Communications

Volumn 345, Issue 4, 2006, Pages 1440-1445

  Gavrieli, Maya ^a   Murphy, Kenneth M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BTLA; Grb 2; ITIM; Phosphopeptides; PI3K p85

Indexed keywords

B AND T LYMPHOCYTE ATTENUATOR; B LYMPHOCYTE RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; PEPTIDE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; SYNTHETIC PEPTIDE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE, TUMOR; GLUTATHIONE TRANSFERASE; GRB2 ADAPTOR PROTEIN; HUMANS; IMMUNOPRECIPITATION; MICE; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PHOSPHORYLATION; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN SUBUNITS; RECEPTORS, IMMUNOLOGIC; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 33744544132     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.05.036     Document Type: Article

References (24)

1. Watanabe N., Gavrieli M., Sedy J.R., Yang J., Fallarino F., Loftin S.K., Hurchla M.A., Zimmerman N., Sim J., Zang X., Murphy T.L., Russell J.H., Allison J.P., and Murphy K.M. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4 (2003) 670-679
2. Sedy J.R., Gavrieli M., Potter K.G., Hurchla M.A., Lindsley R.C., Hildner K., Scheu S., Pfeffer K., Ware C.F., Murphy T.L., and Murphy K.M. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6 (2005) 90-98
3. Gavrieli M., Watanabe N., Loftin S.K., Murphy T.L., and Murphy K.M. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of B and T lymphocyte attenuator required for association with protein tyrosine phosphatases SHP-1 and SHP-2. Biochem. Biophys. Res. Commun. 312 (2003) 1236-1243
4. Cunnick J.M., Mei L., Doupnik C.A., and Wu J. Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2. J. Biol. Chem. 276 (2001) 24380-24387
5. Ronnstrand L., Arvidsson A.K., Kallin A., Rorsman C., Hellman U., Engstrom U., Wernstedt C., and Heldin C.H. SHP-2 binds to Tyr763 and Tyr1009 in the PDGF β-receptor and mediates PDGF-induced activation of the Ras/MAP kinase pathway and chemotaxis. Oncogene 18 (1999) 3696-3702
6. Jackson D.E., Kupcho K.R., and Newman P.J. Characterization of phosphotyrosine binding motifs in the cytoplasmic domain of platelet/endothelial cell adhesion molecule-1 (PECAM-1) that are required for the cellular association and activation of the protein-tyrosine phosphatase, SHP-2. J. Biol. Chem. 272 (1997) 24868-24875
7. Lee K.M., Chuang E., Griffin M., Khattri R., Hong D.K., Zhang W., Straus D., Samelson L.E., Thompson C.B., and Bluestone J.A. Molecular basis of T cell inactivation by CTLA-4. Science 282 (1998) 2263-2266
8. Marengere L.E., Waterhouse P., Duncan G.S., Mittrucker H.W., Feng G.S., and Mak T.W. Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science 272 (1996) 1170-1173
9. Okazaki T., Maeda A., Nishimura H., Kurosaki T., and Honjo T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. USA 98 (2001) 13866-13871
10. Chemnitz J.M., Parry R.V., Nichols K.E., June C.H., and Riley J.L. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J. Immunol. 173 (2004) 945-954
11. Tao R., Wang L., Han R., Wang T., Ye Q., Honjo T., Murphy T.L., Murphy K.M., and Hancock W.W. Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts. J. Immunol. 175 (2005) 5774-5782
12. Yohannan J., Wienands J., Coggeshall K.M., and Justement L.B. Analysis of tyrosine phosphorylation-dependent interactions between stimulatory effector proteins and the B cell co-receptor CD22. J. Biol. Chem. 274 (1999) 18769-18776
13. Greenwald R.J., Freeman G.J., and Sharpe A.H. The B7 family revisited. Annu. Rev. Immunol. 23 (2005) 515-548
14. Schneider H., and Rudd C.E. Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition. Biochem. Biophys. Res. Commun. 269 (2000) 279-283
15. Schneider H., Prasad K.V., Shoelson S.E., and Rudd C.E. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J. Exp. Med. 181 (1995) 351-355
16. Truitt K.E., Hicks C.M., and Imboden J.B. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. J. Exp. Med. 179 (1994) 1071-1076
17. Stein P.H., Fraser J.D., and Weiss A. The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3′-kinase. Mol. Cell Biol. 14 (1994) 3392-3402
18. Raab M., Cai Y.C., Bunnell S.C., Heyeck S.D., Berg L.J., and Rudd C.E. p56Lck and p59Fyn regulate CD28 binding to phosphatidylinositol 3-kinase, growth factor receptor-bound protein GRB-2, and T cell-specific protein-tyrosine kinase ITK: implications for T-cell costimulation. Proc. Natl. Acad. Sci. USA 92 (1995) 8891-8895
19. Okkenhaug K., and Rottapel R. Grb2 forms an inducible protein complex with CD28 through a Src homology 3 domain-proline interaction. J. Biol. Chem. 273 (1998) 21194-21202
20. Kim H.H., Tharayil M., and Rudd C.E. Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling. J. Biol. Chem. 273 (1998) 296-301
21. Coyle A.J., Lehar S., Lloyd C., Tian J., Delaney T., Manning S., Nguyen T., Burwell T., Schneider H., Gonzalo J.A., Gosselin M., Owen L.R., Rudd C.E., and Gutierrez-Ramos J.C. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity 13 (2000) 95-105
22. Okkenhaug K., and Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat. Rev. Immunol. 3 (2003) 317-330
23. Rudd C.E., and Schneider H. Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat. Rev. Immunol. 3 (2003) 544-556
24. Wang J., Auger K.R., Jarvis L., Shi Y., and Roberts T.M. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J. Biol. Chem. 270 (1995) 12774-12780