The relationship between sedative infusion requirements and permissive hypercapnia in critically ill, mechanically ventilated patients

Critical Care Medicine

Volumn 34, Issue 6, 2006, Pages 1668-1673

  Vinayak, Ajeet G ^a   Gehlbach, Brian ^a   Pohlman, Anne S ^a   Hall, Jesse B ^a   Kress, John P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Hypercapnia; Mechanical ventilation; Midazolam; Morphine; Propofol; Sedation

Indexed keywords

MIDAZOLAM; MORPHINE; PROPOFOL; SEDATIVE AGENT;

ADULT; AGE DISTRIBUTION; APACHE; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CONFIDENCE INTERVAL; CONTROLLED STUDY; DATA BASE; DOSE RESPONSE; FEMALE; HUMAN; HYPERCAPNIA; KIDNEY FAILURE; LINEAR REGRESSION ANALYSIS; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RESPIRATORY FAILURE; SCORING SYSTEM; SEDATION; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; TERTIARY HEALTH CARE; UNIVARIATE ANALYSIS; VENTILATED PATIENT;

ADULT; AGED; CRITICAL ILLNESS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERCAPNIA; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; RESPIRATION, ARTIFICIAL; RESPIRATORY INSUFFICIENCY; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 33744540095     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000218412.86977.40     Document Type: Article

References (22)

1. Milberg JA, Davis DR, Steinberg KP, et al: Improved survival of patients with acute respiratory distress syndrome (ARDS): 1983-1993. JAMA 1995; 273:306-309
2. Amato MB, Barbas CS, Medeiros DM, et al: Effect of a protective- ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 1998; 338:347-354
3. Hickling KG, Walsh J, Henderson S, et al: Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study. Crit Care Med 1994; 22:1568-1578
4. Laffey JG, Tanaka M, Engelberts D, et al: Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000; 162:2287-2294
5. Broccard AF, Hotchkiss JR, Vannay C, et al: Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care Med 2001; 164:802-806
6. Bigatello LM, Patroniti N, Sangalli F: Permissive hypercapnia. Curr Opin Crit Care 2001; 7:34-40
7. Weinbroum AA, Halpern P, Rudick V, et al: Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison. Intensive Care Med 1997; 23:1258-1263
8. Hall RI, Sandham D, Cardinal P, et al: Propofol vs midazolam for ICU sedation: A Canadian multicenter randomized trial. Chest 2001; 119:1151-1159
9. Kress JP, Pohlman AS, O'Connor MF, et al: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000; 342:1471-1477
10. Hebert PC, Drummond AJ, Singer J, et al: A simple multiple system organ failure scoring system predicts mortality of patients who have sepsis syndrome. Chest 1993; 104:230-235
11. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829
12. Ramsay MAE, Savege TM, Simpson BR, et al: Controlled sedation with alphaxalone-alphadolone. BMJ 1974; 2:656-659
13. Matthews JNS, Altman DG, Campbell MJ, et al: Analysis of serial measurements in medical research BMJ 1990; 300:230-235
14. Schnider TW, Minto CF, Shafer SL, et al: The influence of age on propofol pharmacodynamics. Anesthesiology 1999; 90:1502-1516
15. Hansen-Flaschen J, Cowen J, Polomano RC: Beyond the Ramsay scale: Need for a validated measure of sedating drug efficacy in the intensive care unit. Crit Care Med 1994; 22:732-733
16. Sessler CN, Gosnell MS, Grap MJ, et al: The Richmond Agitation-Sedation Scale: Validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166:1338-1344
17. McLeod G, Dick J, Wallis C, et al: Propofol in critically ill patients: Effect on lipids. Crit Care Med 1997; 25:1976-1981
18. Barrachina F, Mateu-de Antonio J: Propofol and hypertriglyceridemia: No problem? Crit Care Med 1999; 27:224-225
19. Sanchez-Izuierdo-Riera JA, Caballero-Cubedo RE, Perez-Vela JL, et al: Propofol versus midazolam: Safety and efficacy for sedating the severe trauma patient. Anesth Analg 1998; 86:1219-1224
20. Walder B, Elia N, Henzi I, et al: A lack of evidence of superiority of propofol versus midazolam for sedation in mechanically ventilated critically ill patients: A qualitative and quantitative systematic review. Anesth Analg 2001; 92:975-983
21. Cremer OL, Moons KG, Bouman EA, et al: Long-term propofol infusions and cardiac failure in adult head-injured patients. Lancet 2001; 357:117-118
22. Carrasco G, Molina R, Costa J, et al: Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. A cost-benefit analysis. Chest 1993; 103:557-564