Biochemistry of the Rap-Specific Guanine Nucleotide Exchange Factors PDZ-GEF1 and -2

Methods in Enzymology

Volumn 407, Issue , 2006, Pages 174-186

  Kuiperij, H Bea ^a   Rehmann, Holger ^a   Zwartkruis, Fried J T ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PDZ PROTEIN; RAP PROTEIN;

BACULOVIRUS EXPRESSION SYSTEM; BINDING AFFINITY; BIOCHEMISTRY; CATALYSIS; CELL LINE; CELL STRAIN 3T3; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INSECT CELL; MOLECULAR CLONING; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PURIFICATION; REVIEW; WESTERN BLOTTING;

EID: 33744523804     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(05)07015-1     Document Type: Review

References (18)

1. Bos J.L., de Rooij J., and Reedquist K.A. Rap1 signalling: Adhering to new models. Nat. Rev. Mol. Cell Biol. 2 (2001) 369-377
2. Canaves J.M., and Taylor S.S. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family. J. Mol. Evol. 54 (2002) 17-29
3. de Rooij J., Zwartkruis F.J., Verheijen M.H., Cool R.H., Nijman S.M., Wittinghofer A., and Bos J.L. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396 (1998) 474-477
4. de Rooij J., Boenink N.M., van Triest M., Cool R.H., Wittinghofer A., and Bos J.L. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. J. Biol. Chem. 274 (1999) 38125-38130
5. Franke B., Akkerman J.W., and Bos J.L. Rapid Ca2+-mediated activation of Rap1 in human platelets. EMBO J. 16 (1997) 252-259
6. Gao X., Satoh T., Liao Y., Song C., Hu C.D., Kariya Ki K., and Kataoka T. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. J. Biol. Chem. 276 (2001) 42219-42225
7. Gotoh T., Hattori S., Nakamura S., Kitayama H., Noda M., Takai Y., Kaibuchi K., Matsui H., Hatase O., Takahashi H., Kurata T., and Matsuda M. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 12 (1995) 6746-6753
8. Ichiba T., Hashimoto Y., Nakaya M., Kuraishi Y., Tanaka S., Kurata T., Mochizuki N., and Matsuda M. Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504. J. Biol. Chem. 274 (1999) 14376-14381
9. Kawasaki H., Springett G.M., Mochizuki N., Toki S., Nakaya M., Matsuda M., Housman D.E., and Graybiel A.M. A family of cAMP-binding proteins that directly activate Rap1. Science 282 (1998) 2275-2279
10. Kuiperij H.B., de Rooij J., Rehmann H., van Triest M., Wittinghofer A., Bos J.L., and Zwartkruis F.J. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochim. Biophys. Acta 1593 (2003) 141-149
11. Liao Y., Kariya K., Hu C.D., Shibatohge M., Goshima M., Okada T., Watari Y., Gao X., Jin T.G., Yamawaki-Kataoka Y., and Kataoka T. RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. J. Biol. Chem. 274 (1999) 37815-37820
12. Margarit S.M., Sondermann H., Hall B.E., Nagar B., Hoelz A., Pirrucello M., Bar-Sagi D., and Kuriyan J. Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112 (2003) 685-695
13. Nikolaev V.O., Bunemann M., Hein L., Hannawacker A., and Lohse M.J. Novel single chain cAMP sensors for receptor-induced signal propagation. J. Biol. Chem. 279 (2004) 37215-37218
14. Ohtsuka T., Hata Y., Ide N., Yasuda T., Inoue E., Inoue T., Mizoguchi A., and Takai Y. nRap GEP: A novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Biochem. Biophys. Res. Commun. 265 (1999) 38-44
15. Pak Y., Pham N., and Rotin D. Direct binding of the β1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to ras activation. Mol. Cell. Biol. 22 (2002) 7942-7952
16. Pham N., Cheglakov I., Koch C.A., de Hoog C.L., Moran M.F., and Rotin D. The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP. Curr. Biol. 10 (2000) 555-558
17. Ponsioen B., Zhao J., Riedl J., Zwartkruis F., van der Krogt G., Zaccolo M., Moolenaar W.H., Bos J.L., and Jalink K. Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO Rep. 12 (2004) 1176-1180
18. van Triest M., de Rooij J., and Bos J.L. Measurement of GTP-bound Ras-like GTPases by activation-specific probes. Methods Enzymol. 333 (2001) 343-348