Gene and protein expression in the myometrium in pregnancy and labor

Reproduction

Volumn 131, Issue 5, 2006, Pages 837-850

  Breuiller Fouche, Michelle ^a   Germain, Guy ^b  

^a INSERM   (France)

^b INRA Institut National de la Recherche Agronomique   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN DERIVATIVE; PROTEIN KINASE C; STAT PROTEIN; TOLL LIKE RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

CHILDBIRTH; COMPUTER ANALYSIS; CYTOSKELETON; EXTRACELLULAR MATRIX; FOCAL ADHESION; FUNCTIONAL GENOMICS; GENE ACTIVATION; GENE EXPRESSION PROFILING; HUMAN; LABOR ONSET; MYOMETRIUM; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEOMICS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TISSUE DISTRIBUTION;

ANIMALS; CYTOKINES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LABOR, OBSTETRIC; MYOMETRIUM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PREGNANCY; PREGNANCY TRIMESTERS; PROTEINS; SIGNAL TRANSDUCTION;

EID: 33744504458     PISSN: 14701626     EISSN: None     Source Type: Journal    
DOI: 10.1530/rep.1.00725     Document Type: Review

References (99)

1. Adolfsson PI, Dahle LO, Berg G & Svensson SP 1998 Characterization of alpha2-adrenoceptor subtypes in pregnant human myometrium. Gynecologic and Obstetric Investigation 45 145-150.
2. Aguan K, Carvajal JA, Thompson LP & Weiner CP 2000 Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour. Molecular Human Reproduction 6 1141-1145.
3. Allison DB, Cui X, Page GP & Sabripour M 2006 Microarray data analysis: from disarray to consolidation and consensus. Nature Reviews Genetics 7 55-65.
4. Arntzen KJ, Kjollesdal AM, Halgunset J, Vatten L & Austgulen R 1998 TNF, IL-1, IL-6, IL-8 and soluble TNF receptors in relation to chorioamnionitis and premature labor. Journal of Perinatal Medicine 26 17-26.
5. Bailey J & Europe-Finner GN 2005 Identification of human myometrial target genes of the c-Jun NH2-terminal kinase (JNK) pathway: the role of activating transcription factor 2 (ATF2) and a novel spliced isoform ATF2-small. Journal of Molecular Endocrinology 34 19-35.
6. Bailey J, Tyson-Capper AJ, Gilmore K, Robson SC & Europe-Finner GN 2005 Identification of human myometrial target genes of the cAMP pathway: the role of cAMP-response element binding (CREB) and modulator (CREMalpha and CREMtau2alpha) proteins. Journal of Molecular Endocrinology 34 1-17.
7. Bartlett SR, Sawdy R & Mann GE 1999 Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta: involvement of p38 mitogen-activated protein kinase. Journal of Physiology 520 399-406.
8. Bethin KE, Nagai Y, Sladek R, Asada M, Sadovsky Y, Hudson TJ & Muglia LJ 2003 Microarray analysis of uterine gene expression in mouse and human pregnancy. Molecular Endocrinology 17 1454-1469.
9. Breuiller-Fouche M, Heluy V, Fournier T, Dallot E, Vacher-Lavenu MC & Ferre F 1998 Role of endothelin-1 in regulating proliferation of cultured human uterine smooth muscle cells. Molecular Human Reproduction 4 33-39.
10. Chan EC, Fraser S, Yin S, Yeo G, Kwek K, Fairclough RJ & Smith R 2002 Human myometrial genes are differentially expressed in labor: a suppression subtractive hybridization study. Journal of Clinical Endocrinology and Metabolism 87 2435-2441.
11. Chapman NR, Smyrnias I, Anumba DO, Europe-Finner GN & Robson SC 2005 Expression of the GTP-binding protein (Galphas) is repressed by the nuclear factor kappaB RelA subunit in human myometrium. Endocrinology 146 4994-5002.
12. Charpigny G, Leroy MJ, Breuiller-Fouche M, Tanfin Z, Mhaouty-Kodja S, Robin P, Leiber D, Cohen-Tannoudji J, Cabrol D, Barberis C et al. 2003 A functional genomic study to identify differential gene expression in the preterm and term human myometrium. Biology of Reproduction 68 2289-2296.
13. Chegini N, Tang XM & Ma C 1999 Regulation of transforming growth factor-beta1 expression by granulocyte macrophage-colony-stimulating factor in leiomyoma and myometrial smooth muscle cells. Journal of Clinical Endocrinology and Metabolism 84 4138-4143.
14. Chen HW, Chen JJ, Tzeng CR, Li HN, Chang SJ, Cheng YF, Chang CW, Wang RS, Yang PC & Lee YT 2002 Global analysis of differentially expressed genes in early gestational decidua and chorionic villi using a 9600 human cDNA microarray. Molecular Human Reproduction 8 475-484.
15. Claverie JM 1999 Computational methods for the identification of differential and coordinated gene expression. Human Molecular Genetics 8 1821-1832.
16. Dallot E, Mehats C, Oger S, Leroy MJ & Breuiller-Fouche M 2005 A role for PKCzeta in the LPS-induced translocation NF-kappaB p65 subunit in cultured myometrial cells. Biochimie 87 513-521.
17. Di Liberto G, Dallot E, Eude-Le Parco I, Cabrol D, Ferre F & Breuiller-Fouche M 2003 A critical role for PKC zeta in endothelin-1-induced uterine contractions at the end of pregnancy. American Journal of Physiology, Cell Physiology 285 C599-C607.
18. Douglas AJ, Clarke EW & Goldspink DF 1988 Influence of mechanical stretch on growth and protein turnover of rat uterus. American Journal of Physiology 254 E543-E548.
19. Draghici S, Khatri P, Martins RP, Ostermeier GC & Krawetz SA 2003 Global functional profiling of gene expression. Genomics 81 98-104.
20. Dunckley T, Coon KD & Stephan DA 2005 Discovery and development of biomarkers of neurological disease. Drug Discovery Today 10 326-334.
21. Esplin MS, Fausett MB, Peltier MR, Hamblin S, Silver RM, Branch DW, Adashi EY & Whiting D 2005 The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor. American Journal of Obstetrics and Gynecology 193 404-413.
22. Eude I, Dallot E, Ferre F & Breuiller-Fouche M 2002 Protein kinase Calpha is required for endothelin-1-induced proliferation of human myometrial cells. Biology of Reproduction 66 44-49.
23. Fukuhara K, Kariya M, Kita M, Shime H, Kanamori T, Kosaka C, Orii A, Fujita J & Fujii S 2002 Secreted frizzled related protein 1 is overexpressed in uterine leiomyomas, associated with a high estrogenic environment and unrelated to proliferative activity. Journal of Clinical Endocrinology and Metabolism 87 1729-1736.
24. Fukusumi S, Ogi K, Onda H & Hinuma S 1995 Distribution of thyrotropin-releasing hormone receptor mRNA in rat peripheral tissues. Regulatory Peptides 57 115-121.
25. Ganesh SK, Skelding KA, Mehta L, O'Neill K, Joo J, Zheng G, Goldstein J, Simari R, Billings E, Geller NL et al. 2004 Rationale and study design of the CardioGene Study: genomics of in-stent restenosis. Pharmacogenomics 5 952-1004.
26. Gargiulo AR, Khan-Dawood FS & Dawood MY 1997 Epidermal growth factor receptors in uteroplacental tissues in term pregnancy before and after the onset of labor. Journal of Clinical Endocrinology and Metabolism 82 113-117.
27. Girotti M & Zingg HH 2003 Gene expression profiling of rat uterus at different stages of parturition. Endocrinology 144 2254-2265.
28. Gogarten W, Emala CW, Lindeman KS & Hirshman CA 2001 Oxytocin and lysophosphatidic acid induce stress fiber formation in human myometrial cells via a pathway involving Rho-kinase. Biology of Reproduction 65 401-406.
29. Grammatopoulos DK, Randeva HS, Levine MA, Katsanou ES & Hillhouse EW 2000 Urocortin, but not corticotropin-releasing hormone (CRH), activates the mitogen-activated protein kinase signal transduction pathway in human pregnant myometrium: an effect mediated via R1alpha and R2beta CRH receptor subtypes and stimulation of Gq-proteins. Molecular Endocrinology 14 2076-2091.
30. Guha M & Mackman N 2001 LPS induction of gene expression in human monocytes. Cellular Signalling 13 85-94.
31. Havelock JC, Keller P, Muleba N, Mayhew BA, Casey BM, Rainey WE & Word RA 2005 Human myometrial gene expression before and during parturition. Biology of Reproduction 72 707-719.
32. Heinrich PC, Behrmann I, Muller-Newen G, Schaper F & Graeve L 1998 Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochemical Journal 334 297-314.
33. Hertelendy F & Zakar T 2004 Regulation of myometrial smooth muscle functions. Current Pharmaceutical Design 10 2499-2517.
34. Hertelendy F, Molnar M & Romero R 2002 Interferon gamma antagonizes interleukin-1 beta-induced cyclooxygenase-2 expression and prostaglandin E(2) production in human myometrial cells. Journal of the Society for Gynecological Investigation 9 215-219.
35. Hewitt SC, Collins J, Grissom S, Deroo B & Korach KS 2005 Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism. Molecular Endocrinology 19 657-668.
36. Ho M, Yang E, Matcuk G, Deng D, Sampas N, Tsalenko A, Tabibiazar R, Zhang Y, Chen M, Talbi S et al. 2003 Identification of endothelial cell genes by combined database mining and microarray analysis. Physiological Genomics 13 249-262.
37. Juhasz O, Zhu Y, Garg R, Anisimov SV & Boheler KR 2002 Analysis of altered genomic expression profiles in the senescent and diseased myocardium using cDNA microarrays. European Journal of Heart Failure 4 687-697.
38. Kanehisa M 1997 A database for post-genome analysis. Trends in Genetics 13 375-376.
39. Kanehisa M & Goto S 2000 KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Research 28 27-30.
40. Kato HD, Terao Y, Ogawa M, Matsuda T, Arima T, Kato K, Yong Z & Wake N 2002 Growth-associated gene expression profiles by microarray analysis of trophoblast of molar pregnancies and normal villi. International Jounal of Gynecological Pathology 21 255-260.
41. Kayisli UA, Mahutte NG & Arici A 2002 Uterine chemokines in reproductive physiology and pathology. American Journal of Reproductive Immunology 47 213-221.
42. Keelan JA, Blumenstein M, Helliwell RJ, Sato TA, Marvin KW & Mitchell MD 2003 Cytokines, prostaglandins and parturition-a review. Placenta 24 (Supplement A) S33-S46.
43. Khatri P & Draghici S 2005 Ontological analysis of gene expression data: current tools, limitations, and open problems. Bioinformatics 21 3587-3595.
44. Khatri P, Sellamuthu S, Malhotra P, Amin K, Done A & Draghici S 2005 Recent additions and improvements to the Onto-Tools. Nucleic Acids Research 33 W762-W765.
45. Kimura A, Ohmichi M, Takeda T, Kurachi H, Ikegami H, Koike K, Masuhara K, Hayakawa J, Kanzaki T, Kobayashi M et al. 1999 Mitogen-activated protein kinase cascade is involved in endothelin-1-induced rat puerperal uterine contraction. Endocrinology 140 722-731.
46. Klotz DM, Hewitt SC, Ciana P, Raviscioni M, Lindzey JK, Foley J, Maggi A, DiAugustine RP & Korach KS 2002 Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-I)-induced uterine responses and in vivo evidence for IGF-I/estrogen receptor cross-talk. Journal of Biological Chemistry 277 8531-8537.
47. Leppert PC 1998 Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone. American Journal of Obstetrics and Gynecology 178 713-725.
48. Leroy MJ, Lugnier C, Merezak J, Tanguy G, Olivier S, Le Bec A & Ferre F 1994 Isolation and characterization of the rolipram-sensitive cyclic AMP-specific phosphodiesterase (type IV PDE) in human term myometrium. Cellular Signalling 6 405-412.
49. Leroy MJ, Mehats C, Duc-Goiran P, Tanguy G, Robert B, Dallot E, Mignot TM, Grange G & Ferre F 1999 Effect of pregnancy on PDE4 cAMP-specific phosphodiesterase messenger ribonucleic acid expression in human myometrium. Cellular Signalling 11 31-37.
50. Lewis SE 2005 Gene Ontology: looking backwards and forwards. Genome Biology 6 103.
51. Li Y, Je HD, Malek S & Morgan KG 2004 Role of ERK1/2 in uterine contractility and preterm labor in rats. American Journal of Physiology, Regulative, Integrative and Comparative Physiology 287 R328-R335.
52. Liu Y, Dong W, Chen L, Xiang R, Xiao H, De G, Wang Z & Qi Y 2004 BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. Journal of Biological Chemistry 279 37436-37444.
53. Loch-Caruso RK, Criswell KA, Grindatti CM & Brant KA 2003 Sustained inhibition of rat myometrial gap junctions and contractions by lindane. Reproductive Biology and Endocrinology 1 62.
54. Lopez Bernal A & TambyRaja RL 2000 Preterm labour. Baillieres Best Practice & Research, Clinical Obstetrics and Gynaecology 14 133-153.
55. Macphee DJ & Lye SJ 2000 Focal adhesion signaling in the rat myometrium is abruptly terminated with the onset of labor. Endocrinology 141 274-283.
56. Majewska MD & Vaupel DB 1991 Steroid control of uterine motility via gamma-aminobutyric acidA receptors in the rabbit: a novel mechanism? Journal of Endocrinology 131 427-434.
57. Mangioni S, Vigano P, Lattuada D, Abbiati A, Vignali M & Di Blasio AM 2005 Overexpression of the Wnt5b gene in leiomyoma cells: implications for a role of the Wnt signaling pathway in the uterine benign tumor. Journal of Clinical Endocrinology and Metabolism 90 5349-5355.
58. Marvin KW, Keelan JA, Eykholt RL, Sato TA & Mitchell MD 2002a Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. Molecular Human Reproduction 8 399-408.
59. Marvin KW, Keelan JA, Eykholt RL, Sato TA & Mitchell MD 2002b Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua. American Journal of Obstetrics and Gynecology 187 728-734.
60. Mehats C, Tanguy G, Dallot E, Cabrol D, Ferre F & Leroy MJ 2001 Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? Journal of Clinical Endocrinology and Metabolism 86 5358-5365.
61. Mehats C, Tanguy G, Paris B, Robert B, Pernin N, Ferre F & Leroy MJ 2000 Pregnancy induces a modulation of the cAMP phosphodiesterase 4-conformers ratio in human myometrium: consequences for the utero-relaxant effect of PDE4-selective inhibitors. Journal of Pharmacology and Experimental Therapeutics 292 817-823.
62. Mhaouty-Kodja S, Houdeau E & Legrand C 2004 Regulation of myometrial phospholipase C system and uterine contraction by beta-adrenergic receptors in midpregnant rat. Biology of Reproduction 70 570-576.
63. Moore F, Da Silva C, Wilde JI, Smarason A, Watson SP & Lopez Bernal A 2000 Up-regulation of p21- and RhoA-activated protein kinases in human pregnant myometrium. Biochemical and Biophysical Research Communications 269 322-326.
64. Morimoto T, Head JR, MacDonald PC & Casey ML 1998 Thrombospondin-1 expression in human myometrium before and during pregnancy, before and during labor, and in human myometrial cells in culture. Biology of Reproduction 59 862-870.
65. Muhle RA, Pavlidis P, Grundy WN & Hirsch E 2001 A high-throughput study of gene expression in preterm labor with a subtractive microarray approach. American Journal of Obstetrics and Gynecology 185 716-724.
66. Nishimura M & Naito S 2005 Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biological & Pharmiceutical Bulletin 28 886-892.
67. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK et al. 2004 Control of pancreas and liver gene expression by HNF transcription factors. Science 303 1378-1381.
68. Ohmichi M, Koike K, Kimura A, Masuhara K, Ikegami H, Ikebuchi Y, Kanzaki T, Touhara K, Sakaue M, Kobayashi Y et al. 1997 Role of mitogen-activated protein kinase pathway in prostaglandin F2alpha-induced rat puerperal uterine contraction. Endocrinology 138 3103-3111.
69. Oldenhof AD, Shynlova OP, Liu M, Langille BL & Lye SJ 2002 Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. American Journal of Physiology, Cell Physiology 283 C1530-C1539.
70. Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA & Norman JE 2003 Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Molecular Human Reproduction 9 41-45.
71. Otun HA, MacDougall MW, Bailey J, Europe-Finner GN & Robson SC 2005 Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor. Journal of the Society for Gynecological Investigation 12 185-190.
72. Ozaki H, Yasuda K, Kim YS, Egawa M, Kanzaki H, Nakazawa H, Hori M, Seto M & Karaki H 2003 Possible role of the protein kinase C/CPI-17 pathway in the augmented contraction of human myometrium after gestation. British Journal of Pharmacology 140 1303-1312.
73. Papadopoulou N, Chen J, Randeva HS, Levine MA, Hillhouse EW & Grammatopoulos DK 2004 Protein kinase A-induced negative regulation of the corticotropin-releasing hormone R1alpha receptor-extracellularly regulated kinase signal transduction pathway: the critical role of Ser301 for signaling switch and selectivity. Molecular Endocrinology 18 624-639.
74. Phaneuf S, Carrasco MP, Europe-Finner GN, Hamilton CH & Lopez Bernal A 1996 Multiple G proteins and phospholipase C isoforms in human myometrial cells: implication for oxytocin action. Journal of Clinical Endocrinology and Metabolism 81 2098-2103.
75. Qi M & Elion EA 2005 Formin-induced actin cables are required for polarized recruitment of the Ste5 scaffold and high level activation of MAPK Fus3. Journal of Cell Science 118 2837-2848.
76. Rehman KS, Yin S, Mayhew BA, Word RA & Rainey WE 2003 Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women. Molecular Human Reproduction 9 681-700.
77. Riley M, Wu X, Baker PN & Taggart MJ 2005a Gestational-dependent changes in the expression of signal transduction and contractile filament-associated proteins in mouse myometrium. Journal of the Society for Gynecological Investigation 12 e33-e43.
78. Riley M, Baker PN, Tribe RM & Taggart MJ 2005b Expression of scaffolding, signalling and contractile-filament proteins in human myometria: effects of pregnancy and labour. Journal of Cellular and Molecular Medicine 9 122-134.
79. Robin P, Boulven I, Desmyter C, Harbon S & Leiber D 2002 ET-1 stimulates ERK signaling pathway through sequential activation of PKC and Src in rat myometrial cells. American Journal of Physiology, Cell Physiology 283 C251-C260.
80. Robin P, Boulven I, Bole-Feysot C, Tanfin Z & Leiber D 2004 Contribution of PKC-dependent and -independent processes in temporal ERK regulation by ET-1, PDGF, and EGF in rat myometrial cells. American Journal of Physiology, Cell Physiology 286 C798-C806.
81. Romero R, Kuivaniemi H & Tromp G 2002 Functional genomics and proteomics in term and preterm parturition. Journal of Clinical Endocrinology and Metabolism 87 2431-2434.
82. Ruzycky AL 1998 Down-regulation of the mitogen-activated protein kinase cascade immediately before parturition in the rat myometrium. Journal of the Society for Gynecological Investigation 5 304-310.
83. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G & Conklin BR 2005 Identifying genetic networks underlying myometrial transition to labor. Genome Biology 6 R12.
84. Sehringer B, Zahradnik HP, Simon M, Ziegler R, Noethling C & Schaefer WR 2004 mRNA expression profiles for corticotrophin-releasing hormone, urocortin, CRH-binding protein and CRH receptors in human term gestational tissues determined by real-time quantitative RT-PCR. Journal of Molecular Endocrinology 32 339-348.
85. Shen Y, Iqbal J, Xiao L, Lynch RC, Rosenwald A, Staudt LM, Sherman S, Dybkaer K, Zhou G, Eudy JD et al. 2004 Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs. BMC Immunology 5 20.
86. Shynlova O, Tsui P, Dorogin A, Chow M & Lye SJ 2005 Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium. Biology of Reproduction 73 773-780.
87. Shynlova O, Oldenhof A, Dorogin A, Xu Q, Mu J, Nashman N & Lye SJ 2006 Myometrial Apoptosis: Activation of the Caspase Cascade in the Pregnant Rat Myometrium at Midgestation. Biology of Reproduction [in press].
88. Sooranna SR, Lee Y, Kim LU, Mohan AR, Bennett PR & Johnson MR 2004 Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells. Molecular Human Reproduction 10 109-113.
89. Stein RC & Waterfield MD 2000 PI3K inhibition: a target for drug development? Molecular Medicine Today 6 347-357.
90. Tashima LS, Yamamoto SY, Yasuda M, Millar LK & Bryant-Greenwood GD 2002 Decidual relaxins: gene and protein up-regulation in preterm premature rupture of the membranes by complementary DNA arrays and quantitative immunocytochemistry. American Journal of Obstetrics and Gynecology 187 785-797.
91. Tierney EP, Tulac S, Huang ST & Giudice LC 2003 Activation of the protein kinase A pathway in human endometrial stromal cells reveals sequential categorical gene regulation. Physiological Genomics 16 47-66.
92. Wang H & Hirsch E 2003 Bacterially-induced preterm labor and regulation of prostaglandin-metabolizing enzyme expression in mice: the role of toll-like receptor 4. Biology of Reproduction 69 1957-1963.
93. Wang Y, Matsuo H, Kurachi O & Maruo T 2002 Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells. European Journal of Endocrinology 146 447-456.
94. Williams SJ, White BG & MacPhee DJ 2005 Expression of alpha5 integrin (Itga5) is elevated in the rat myometrium during late pregnancy and labor: implications for development of a mechanical syncytium. Biology of Reproduction 72 1114-1124.
95. Wong DJ & Chang HY 2005 Learning more from microarrays: insights from modules and networks. Journal of Investagative Dermatology 125 175-182.
96. Wu WX, Zhang Q, Ma XH, Unno N & Nathanielsz PW 1999 Suppression subtractive hybridization identified a marked increase in thrombospondin-1 associated with parturition in pregnant sheep myometrium. Endocrinology 140 2364-2371.
97. Yu JT & Lopez Bernal A 1998 The cytoskeleton of human myometrial cells. Journal of Reproduction and Fertility 112 185-198.
98. Zhong M, Yang M & Sanborn BM 2003 Extracellular signal-regulated kinase 1/2 activation by myometrial oxytocin receptor involves Galpha(q)Gbetagamma and epidermal growth factor receptor tyrosine kinase activation. Endocrinology 144 2947-2956.
99. Zhong M, Ku CY & Sanborn BM 2005 Pathways used by relaxin to regulate myometrial phospholipase C. Annals of the New York Acadamies of Science 1041 300-304.