Incorporating serotypes into family based association studies using the MFG test

Annals of Human Genetics

Volumn 70, Issue 4, 2006, Pages 541-553

  Minassian, S L ^a,b   Palmer, C G S ^b   Turunen, J A ^c   Paunio, T ^c   Lonnqvist J ^c   Peltonen, L ^c   Woodward, J A ^d   Sinsheimer, Janet S ^b,e  

^a ELAN PHARMACEUTICALS   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gene by environment; Gene by gene; Maternal fetal genotype incompatibility; Missing data; Non codominant data; Rhesus incompatibility; Serotypes

Indexed keywords

RHESUS D ANTIGEN;

ALLELE; ANALYTICAL ERROR; ARTICLE; CONTROLLED STUDY; COST CONTROL; DISEASE PREDISPOSITION; FAMILY; FEMALE; GENETIC ASSOCIATION; GENETIC INCOMPATIBILITY; GENETIC RISK; GENOTYPE; HUMAN; MATHEMATICAL COMPUTING; MOTHER FETUS RELATIONSHIP; PRIORITY JOURNAL; PROBABILITY; RHESUS INCOMPATIBILITY; SAMPLE SIZE; SCHIZOPHRENIA; SEROTYPE; SIMULATION;

BLOOD GROUP INCOMPATIBILITY; BLOOD GROUPING AND CROSSMATCHING; COMPUTER SIMULATION; FEMALE; GENOTYPE; HISTOCOMPATIBILITY TESTING; HUMANS; LIKELIHOOD FUNCTIONS; LINKAGE (GENETICS); MALE; MODELS, GENETIC; NUCLEAR FAMILY; PREGNANCY; RH-HR BLOOD-GROUP SYSTEM; RISK FACTORS; SAMPLE SIZE; SCHIZOPHRENIA; SEROTYPING;

EID: 33744502594     PISSN: 00034800     EISSN: 14691809     Source Type: Journal    
DOI: 10.1111/j.1469-1809.2005.00243.x     Document Type: Article

References (26)

1. Chen, Y. H. (2004) New approach to association testing in case-parent designs under informative parental missingness. Genet Epidemiol 27, 131-40.
2. Cordell, H. J., Barratt, B. J. & Clayton, D. G. (2004) Case/ pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol 26, 167-185.
3. Cordell, H. J. (2004) Properties of case/pseudocontrol analysis for genetic association studies: Effects of recombination, ascertainment, and multiple affected offspring. Genet Epidemiol 26, 186-205.
4. Daniels, G. (2004) Molecular blood grouping. Vox Sang 87, S63-S66.
5. Ekelund, J., Hovatta, I., Parker, A., Paunio, T., Varilo, T., Martin, R., Suhonen, J., Ellonen, P., Chan, G., Sinsheimer, J. S., Sobel, E., Juvonen, H., Arajárvi, R., Partonen, T., Suvisaari, J., Lónnqvist, J., Meyer, J. & Peltonen, L. (2001) Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 15, 1611-1617.
6. Ekelund, J., Lichtermann, D., Hovatta, I., Ellonen, P., Suvisaari, J., Terwilliger, J. D., Juvonen, H., Varilo, T., Arajárvi, R., Kokko-Sahin, M. L., Lónnqvist, J. & Peltonen, L. (2000) Genome-wide scan for schizophrenia in the Finnish population: Evidence for a locus on chromosome 7q22. Hum Mol Genet 9, 1049-1057.
7. Horvath, S., Xu, X. & Laird, N. M. (2001) The family based association test method: Strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9, 301-306.
8. Hovatta, I., Varilo, T., Suvisaari, J., Terwilliger, J. D., Ollikainen, V., Arajárvi, R., Juvonen, H., Kokko-Sahin, M-L., Vaisanen, L., Mannila, H., Lónnqvist, J. & Peltonen, L. (1999) A genomewide screen for schizophrenia genes in an. isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet 65, 1114-1124.
9. Kraft, P., Palmer, C. G., Woodward, A. J., Turunen, J. A., Minassian, S., Paunio, T., Lónnqvist, J., Peltonen, L. & Sinsheimer, J. S. (2004) RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order. Eur J Hum Genet 12, 192-8.
10. Kraft, P., Hsieh, H.-J., Cordell, H. J. & Sinsheimer, J. (2005) A Conditional-on-exchangeable-parental-genotypes likelihood that remains unbiased at the causal locus under multiple-affected-sibling ascertainment. Genet Epidemiol 29, 87-90.
11. Lange, K. (1991) SEARCH 3.0. Department of Biomathematics, University of California Los Angeles, Los Angeles, California.
12. Little, R. J. & Rubin, D. B. (1987) Statistical Analysis with Missing Dat. pp. 127 -139. New York: John Wiley and Sons.
13. Minassian, S. L., Palmer, C. G. S. & Sinsheimer, J. S. (2005) An Exact Maternal-Fetal Genotype Incompatibility (MFG) Test. Genet Epidemiol 28, 83-95.
14. Palmer, C. G. S., Turunen, J. A., Sinsheimer, J. S., Minassian, S., Paunio, T., Lónnqvist, J., Peltonen, L. & Woodward, J. A. (2002) RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility. Am J Hum Genet 71, 1312-1319.
15. Paunio, T., Ekelund, J., Varilo, T., Parker, A., Hovatta, I., Turunen, J. A., Rinard, K., Foti, A., Terwilliger, J. D., Juvonen, H., Suvisaari, J., Arajarvi, R., Suokas, J., Partonen, T., Lónnqvist, J., Meyer, J. & Peltonen, L. (2001) Genome-wide scan in nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 10, 1611-1617.
16. Plevyak, M. P. & Carr, S. R. (2001) Rhesus Isoimmunization. Med Health RI 84, 148-51.
17. Schaid, D. J. & Sommer, S. S. (1993) Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 53, 1114-1126.
18. Schaid, D. J. & Sommer, S. S. (1994) Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55, 402-9.
19. Sinsheimer, J. S., Palmer, C. G. S. & Woodward, J. A. (2003) Detecting genotype combinations that increase risk for disease: The maternal fetal genotype incompatibility test. Genet Epidemiol 24, 1-13.
20. Spielman, R. S. & Ewens, W. J. (1996) The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59, 983-9.
21. Strachan, T. & Read, A. P. (1999) Human Molecular Genetics, 2 nd Ed. New York: John Wiley.
22. Wagner, F. F. & Flegel, W. A. (2000) RHD gene deletions occurred in the Rhesus box. Blood 95, 3662-8.
23. Weinberg, C. R., Wilcox, A. J. & Lie, R. T. (1998) A log-linear approach to case-parent-triad data: Assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62, 969-978.
24. Weinberg, C. R. (1999a) Allowing for missing parents in genetics studies of case-parent triads. Am J Hum Genet 64, 1186-1193.
25. Weinberg, C. R. (1999b) Methods for detection of parent-of-origin effects in genetic studies of case-parent triads. Am J Hum Genet 65, 229-235.
26. Wilcox, A. J., Weinberg, C. R. & Lie, R. T. (1998) Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads."Am J Epidemiol 148, 893-901.