An exact maternal-fetal genotype incompatibility (MFG) test

Genetic Epidemiology

Volumn 28, Issue 1, 2005, Pages 83-95

  Minassian, Sonia L ^a   Palmer, Christina G S ^a   Sinsheimer, Janet S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Association test; Gene environment interaction; Gene gene interaction; Maternal effects; Maternal fetal interaction; Permutation test; Randomization test; Small sample test

Indexed keywords

ARTICLE; ASSOCIATION TEST; ASYMPTOTIC TEST; CHILD ALLELIC EFFECT; ENVIRONMENTAL FACTOR; ERROR; EXACT TEST; FETUS; GENE ENVIRONMENT INTERACTION; GENE FREQUENCY; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC INCOMPATIBILITY; GENOTYPE; MATERNAL ALLELIC EFFECT; MATERNAL FETAL GENOTYPE INCOMPATIBILITY TEST; MOTHER; NULL ALLELE; PERMUTATION TEST; PROGENY; RANDOMIZATION; RANDOMIZATION TEST; RISK; SAMPLE SIZE; SIMULATION; SMALL SAMPLE TEST; STATISTICAL ANALYSIS; TYPE I ERROR;

ADULT; ALGORITHMS; CHILD; COMPUTER SIMULATION; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; GENOTYPE; HUMANS; MALE; RISK FACTORS; SAMPLE SIZE;

EID: 11144279307     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/gepi.20027     Document Type: Article

References (24)

1. Berger WV. 2000. Pros and cons of permutation tests in clinical trials. Stat Med 19:1319-1328.
2. Cleves MA, Olson JM, Jacobs KB. 1997. Exact transmission-disequilibrium tests with multiallelic markers. Genet Epidemiol 14:337-347.
3. Cordell HJ. 2004. Properties of case/pseudocontrol analysis for genetic association studies: effects of recombination, ascertainment, and multiple affected offspring. Genet Epidemiol 26:186-205.
4. Cordell HJ, Barratt BJ, Clayton DG. 2004. Case/pseudocontrol analysis in genetic association studies: a unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol 26:167-185.
5. Dudbridge F. 2003. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-121.
6. Efron B, Tibshirani RJ. 1993. An introduction to the bootstrap. New York: CRC Press.
7. Horvath S, Xu X, Laird NM. 2001. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-306.
8. Kraft P, Palmer CG, Woodward AJ, Turunen JA, Minassian S, Paunio T, Lonnqvist J, Peltonen L, Sinsheimer JS. 2004. RHD maternal-fetal genotype incompatibility and schizophrenia: extending the MFG test to include multiple siblings and birth order. Eur J Hum Genet 12:192-198.
9. Lancaster HO. 1961. Significance tests in discrete distributions. J Am Stat Assoc 56:223-234.
10. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
11. Lange K. 1991. SEARCH 3.0. Department of Biomathematics, UCLA, Los Angeles, California.
12. Lazzeroni LC, Lange K. 1998. A permutation framework for extending the transmission disequilibrium test. Hum Hered 48:67-81.
13. Morris AP, Curnow RN, Whittaker JC. 1997. Randomization tests of disease-marker associations. Ann Hum Genet 61:49-60.
14. Palmer CGS, Turunen JA, Sinsheimer JS, Minassian S, Paunio T, Lönnqvist J, Peltonen L, Woodward JA. 2002. RHD maternal-fetal genotype incompatibility increases schizophrenia susceptibility. Am J Hum Genet 71:1312-1319.
15. Schaid DJ. 1996. General score tests for association of genetic markers with disease using cases and their parents. Genet Epidemiol 13:423-449.
16. Schaid DJ, Sommer SS. 1993. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 53:1114-1126.
17. Schaid DJ, Sommer SS. 1994. Comparison of statistics for candidate-gene association studies using cases and parents. Am J Hum Genet 55:402-409.
18. Sinsheimer JS, Palmer CGS, Woodward JA. 2003. Detecting genotype combinations that increase risk for disease: The maternal-fetal genotype incompatibility test. Genet Epidemiol 24:1-13.
19. Spielman RS, Ewens WJ. 1996. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59:983-989.
20. Umbach DM, Weinberg CR. 2000. The use of case-parent triads to study joint effects of genotype and exposure. Am J Hum Genet 66:251-261.
21. Weinberg CR. 1999. Analysis of genetic studies with partial triads. Am J Hum Genet 64:1186-1193.
22. Weinberg CR, Wilcox AJ, Lie RT. 1998. A log-linear approach to case-parent-triad data: assessing effects of disease genes that act either directly or through maternal effects and that may be subject to parental imprinting. Am J Hum Genet 62:969-978.
23. Whittaker JC, Thompson DJ. 1999. Finite-sample properties of family-based association tests. Am J Hum Genet 64:910-915.
24. Wilcox AJ, Weinberg CR, Lie RT. 1998. Distinguishing the effects of maternal and offspring genes through studies of "case-parent triads." Am J Epidemiol 148:893-901.