Anchorage on fibronectin via VLA-5 (α5β1 integrin) protects rheumatoid synovial cells from Fas-induced apoptosis

Annals of the Rheumatic Diseases

Volumn 65, Issue 6, 2006, Pages 721-727

  Kitagawa, A ^a   Miura, Y ^a   Saura, R ^a   Mitani, M ^a   Ishikawa, H ^a   Hashiramoto, A ^a   Yoshiya, S ^a   Shiozawa, S ^a   Kurosaka, M ^a  

^a KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; FAS ANTIGEN; FIBRONECTIN; MESSENGER RNA; MONOCLONAL ANTIBODY; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLYLYSINE; PROTEIN ANTIBODY; URIDINE TRIPHOSPHATE; VERY LATE ACTIVATION ANTIGEN 5;

APOPTOSIS; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG ACTIVITY; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INCUBATION TIME; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD95; APOPTOSIS; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CASPASE 3; CASPASES; CELL ADHESION; CELLS, CULTURED; COLLAGEN TYPE XI; FIBROBLASTS; FIBRONECTINS; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INTEGRIN ALPHA5BETA1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; SYNOVIAL MEMBRANE;

EID: 33744477350     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2005.041707     Document Type: Article

References (52)

1. Hirohata K, Kobayashi I. Fine structures of the synovial tissues in rheumatoid arthritis. Kobe J Med Sci 1964;10:195-225.
2. Barland P, Novikoff AB, Hamerman D. Fine structure and cytochemistry of the rheumatoid synovial membrane, with special reference to lysosomes. Am J Pathol 1964;44:853-66.
3. Kobayashi I, Ziff M. Electron microscopic studies of the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 1975;18:475-83.
4. Shiozawa S, Jasin HE, Ziff M. Absence of immunoglobulins in rheumatoid cartilage-pannus junctions. Arthritis Rheum 1980;23:816-21.
5. Gay S, Gay RE, Koopman WJ. Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction? Ann Rheum Dis 1993;52(suppl 1):S39-47.
6. Shiozawa S, Shiozawa K, Fujita T. Morphologic observations in the early phase of the cartilage-pannus junction. Light and electron microscopic studies of active cellular pannus. Arthritis Rheum 1983;26:472-8.
7. Nakajima T, Aono H, Hasunuma T, Yamamoto K, Shirai T, Hirohata K, et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 1995;38:485-91.
8. Baier A, Meineckel I, Gay S, Pap T. Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol 2003;15:274-9.
9. Ceponis A, Hietanen J, Tamulaitiene M, Partsch G, Patiala H, Konttinen YT. A comparative quantitative morphometric study of cell apoptosis in synovial membranes in psoriatic, reactive and rheumatoid arthritis. Rheumatology (Oxford) 1999;38:431-40.
10. Casciola-Rosen L, Nicholson DW, Chong T, Rowan KR, Thornberry NA, Miller DK, et al. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J Exp Med 1990;183:1957-64.
11. McCarthy NJ, Whyte MK, Gilbert CS, Evan GI. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. J Cell Biol 1997;136:215-27.
12. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991;66:233-43.
13. Hashimoto H, Tanaka M, Suda T, Tomita T, Hayashida K, Takeuchi E, et al. Soluble Fas ligand in the joints of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 1998;41:657-o2.
14. Kobayashi T, Okamoto K, Kobata T, Hasunuma T, Sumida T, Nishioka K. Tumor necrosis factor alpha regulation of the FAS-mediated apoptosis-signaling pathway in synovial cells. Arthritis Rheum 1999;42:519-26.
15. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid arthritis synovium. J Clin Invest 1995;96:1631-8.
16. Matsumoto S, Muller-Ladner U, Gay RE, Nishioka K, Gay S. Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts. J Rheumatol 1996;23:1345-52.
17. Franz JK, Pap T, Hummel KM, Nawrath M, Aicher WK, Shigeyama Y, et al. Expression of sentrin, a novel antiapoptotic molecule, at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 2000;43:599-607.
18. Perlman H, Liu H, Georganas C, Koch AE, Shamiyeh E, Haines GK 3rd, et al. Differential expression pattern of the antiapoptotic proteins, Bcl-2 and FLIP, in experimental arthritis. Arthritis Rheum 2001;44:2899-908.
19. Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 1992;69:11-25.
20. Meredith JE Jr, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-61.
21. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-26.
22. Shiozawa S, Ziff M. Immunoelectron microscopic demonstration of fibronectin in rheumatoid pannus and at the cartilage-pannus junction. Ann Rheum Dis 1983;42:254-63.
23. Scolt DL, Wainwright AC, Walton KW, Williamson N. Significance of fibronectin in rheumatoid arthritis and osteoarthrosis. Ann Rheum Dis 1981;40:142-53.
24. Carnemolla B, Cutolo M, Castellani P, Balza E, Raffanti S, Zardi L. Characterization of synovial fluid fibronectin from patients with rheumatic inflammatory diseases and healthy subjects. Arthritis Rheum 1984;27:913-21.
25. Shiozawa K, Shiozawa S, Shimizu S, Fujita T. Fibronectin on the surface of articular cartilage in rheumatoid arthritis. Arthritis Rheum 1984;27:615-22.
26. Zhang Z, Vuori K, Reed JC, Ruoslahti E. The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 1995;92:6161-5.
27. O'Brien V, Frisch SM, Juliano RL. Expression of the integrin alpha 5 subunit in HT29 colon carcinoma cells suppresses apoptosis triggered by serum deprivation. Exp Cell Res 1996;224:208-13.
28. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
29. Barillari G, Albonici L, Incerpi S, Bogetto L, Pistritto G, Volpi A, et al. Inflammatory cytokines stimulate vascular smooth muscle cells locomotion and growth by enhancing alpha5beta1 integrin expression and function. Atherosclerosis 2001;154:377-85.
30. Barillari G, Sgadari C, Palladino C, Gendelman R, Caputo A, Morris CB, et al. Inflammatory cytokines synergize with the HIV-1 Tat protein to promote angiogenesis and Kaposi's sarcoma via induction of basic fibroblast growth factor and the alpha v beta 3 integrin. J Immunol 1999;163:1929-35.
31. Cifone MG, De Maria R, Roncaioli P, Rippo MR, Azuma M, Lanier LL, et al. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1994;180:1547-52.
32. Bao W, Stromblad S. Use of an immobilized monoclonal antibody to examine integrin alpha5beta1 signaling independent of cell spreading. Biol Proced Online 2002;4:81-7.
33. Garcia-Gila M, Lopez-Martin EM, Garcia-Pardo A. Adhesion to fibronectin via alpha4 integrin (CD49d) protects B cells from apoptosis induced by serum deprivation but not via IgM or Fas/Apo-1 receptors. Clin Exp Immunol 2002;127:455-62.
34. Johansson S, Svineng G, Wennerberg K, Armulik A, Lohikangas L. Fibronectin-integrin interactions. Front Biosci 1997;2:d126-46.
35. Nikkari L, Aho H, Yli-Jama T, Larjava H, Jalkanen M, Heino J. Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer. Am J Pathol 1993;142:1019-27.
36. el Gabalawy H, Wilkins J. Beta 1 (CD29) integrin expression in rheumatoid synovial membranes: an immunohistologic study of distribution patterns. J Rheumatol 1993;20:231-7.
37. Ishikawa H, Hirata S, Nishibayashi Y, Imura S, Kubo H, Ohno O. The role of adhesion molecules in synovial pannus formation in rheumatoid arthritis. Clin Orthop 1994:297-303.
38. Ishikawa H, Hirata S, Andoh Y, Kubo H, Nakagawa N, Nishibayashi Y, et al. An immunohistochemical and immunoelectron microscopic study of adhesion molecules in synovial pannus formation in rheumatoid arthritis. Rheumatol Int 1990;16:53-60.
39. Rinaldi N, Schwarz-Eywill M, Weis D, Leppelmann-Jansen P, Lukoschek M, Keilholz U, et al. Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins. Ann Rheum Dis 1997;56:45-51.
40. Hasunuma T, Kayagaki N, Asahara H, Motokawa S, Kobata T, Yagita H, et al. Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum 1997;40:80-6.
41. Okamoto K, Kobayashi T, Kobata T, Hasunuma T, Kato T, Sumida T, et al. Fas-associated death domain protein is a Fas-mediated apoptosis modulator in synoviocytes. Rheumatology (Oxford) 2000;39:471-80.
42. Catrina AI, Ulfgren AK, Lindblad S, Grondal L, Klareskog L. Low levels of apoptosis and high FLIP expression in early rheumatoid arthritis synovium. Ann Rheum Dis 2002;61:934-6.
43. Perlman H, Georganas C, Pagliari U, Koch AE, Haines K 3rd, Pope RM. Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability. J Immunol 2000;164:5227-35.
44. Stoker M, O'Neill C, Berryman S, Waxman V. Anchorage and growth regulation in normal and virus-transformed cells. Int J Cancer 1968;3:683-93.
45. Dike LE, Farmer SR. Cell adhesion induces expression of growth-associated genes in suspension-arrested fibroblasts. Proc Natl Acad Sci USA 1988;85:6792-6.
46. Gendron S, Couture J, Aoudjit F. Integrin alpha2beta1 inhibits Fas-mediated apoptosis in T lymphocytes by protein phosphatase 2A-dependent activation of the MAPK/ERK pathway. J Biol Chem. 2003;278: 48033-43, Epub 2003 Sep 17..
47. Sarkissian M, Lafyatis R. Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts. J Immunol 1999;162:1772-9.
48. Nakayamada S, Saito K, Fujii K, Yasuda M, Tamura M, Tanaka Y. Beta1 integrin-mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas-mediated apoptosis. Arthritis Rheum 2003;48:1239-48.
49. Mould AP, Humphries MJ. Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Curr Opin Cell Biol 2004;16:544-51.
50. Hino K, Shiozawa S, Kuroki Y, Ishikawa H, Shiozawa K, Sekiguchi K, et al. EDA-containing fibronectin is synthesized from rheumatoid synovial fibroblast-like cells. Arthritis Rheum 1995;38:678-83.
51. Hino K, Maeda T, Sekiguchi K, Shiozawa K, Hirano H, Sakashita E, et al. Adherence of synovial cells on EDA-containing fibronectin. Arthritis Rheum 1996;39:1685-92.
52. Shiozawa S, Yoshihara R, Kuroki Y, Fujita T, Shiozawa K, Imura S. Pathogenic importance of fibronectin in the superficial region of articular cartilage as a local factor for the induction of pannus extension on rheumatoid articular cartilage. Ann Rheum Dis 1992;51:869-73.