Activation of FGFR1β signaling pathway promotes survival, migration and resistance to chemotherapy in acute myeloid leukemia cells

Leukemia

Volumn 20, Issue 6, 2006, Pages 979-986

  Karajannis, M A ^a,b   Vincent, L ^b   DiRenzo, R ^c   Shmelkov, S V ^b   Zhang, F ^b   Feldman, E J ^b   Bohlen, P ^c   Zhu, Z ^c   Sun, H ^c   Kussie, P ^c   Rafii, S ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Acute myeloid leukemia; Animal studies; Cell signaling; Chemotherapy; Fibroblast growth factor; Fibroblast growth factor receptor

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; NEUTRALIZING ANTIBODY; PHOSPHATIDYLINOSITOL 3 KINASE; AGOUTI RELATED PROTEIN; AGOUTI-RELATED PROTEIN; ANTIBODY; ANTINEOPLASTIC AGENT; FGFR1 PROTEIN, HUMAN; MESSENGER RNA; PROTEIN SUBUNIT; SIGNAL PEPTIDE;

ACUTE GRANULOCYTIC LEUKEMIA; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG RESISTANCE; DRUG TARGETING; GENE ACTIVATION; GENE TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; XENOTRANSPLANTATION; ACUTE DISEASE; ANIMAL; CELL CULTURE; CELL MOTION; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; MOUSE MUTANT; MYELOID LEUKEMIA; PHOSPHORYLATION; TUMOR CELL LINE;

ACUTE DISEASE; AGED, 80 AND OVER; ANIMALS; ANTIBODIES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; FIBROBLAST GROWTH FACTOR 2; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LEUKEMIA, MYELOID; MALE; MICE; MICE, SCID; PHOSPHORYLATION; PROTEIN SUBUNITS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 33744470077     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404203     Document Type: Article

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