Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma

Journal of Cancer Research and Clinical Oncology

Volumn 132, Issue 2, 2006, Pages 121-128

  Waldner, Raimund ^a   Laschan, Claudia ^a   Lohninger, Alfred ^b   Gessner, Martin ^a   Tüchler, Heinz ^a   Huemer, Marlies ^a   Spiegel, Wolfgang ^b   Karlic, Heidrun ^a  

^a HANUSCH HOSPITAL   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anthracycline; L carnitine; Oxidative metabolism

Indexed keywords

ANTINEOPLASTIC AGENT; CARNITINE; CARNITINE ACYLTRANSFERASE; CARNITINE PALMITOYLTRANSFERASE; DOXORUBICIN; MESSENGER RNA; ORGANIC CATION TRANSPORTER; SLC22A5 PROTEIN, HUMAN; VITAMIN B COMPLEX;

ARTICLE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; LEUKOCYTE; LIPID PEROXIDATION; METABOLISM; NONHODGKIN LYMPHOMA; OXIDATION REDUCTION REACTION; RANDOMIZED CONTROLLED TRIAL; TIME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARNITINE; CARNITINE ACYLTRANSFERASES; CARNITINE O-PALMITOYLTRANSFERASE; DOXORUBICIN; HUMANS; LEUKOCYTES; LIPID PEROXIDATION; LYMPHOMA, NON-HODGKIN; ORGANIC CATION TRANSPORT PROTEINS; OXIDATION-REDUCTION; RNA, MESSENGER; TIME FACTORS; VITAMIN B COMPLEX;

EID: 33646974840     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-005-0054-8     Document Type: Article

References (50)

1. Abd-Allah AR, Al-Majed AA, Al-Yahya AA, Fouda SI, Al-Shabana OA (2005) L-Carnitine halts apoptosis and myelosuppression induced by carboplatin in rat bone marrow cell cultures (BMC). Arch Toxicol 79:406-413 (Pubitemid 41040176)
2. Abdel-aleem S, el-Merzabani MM, Sayed-Ahmed M, Taylor DA, Lowe JE (1997) Acute and chronic effects of adriamycin on fatty acid oxidation in isolated cardiac myocytes. J Mol Cell Cardiol 29:789-797 (Pubitemid 27192884)
3. Al-Majed AA, Gdo AM, Al-Shabanah OA, Mansour MA (2002) Alpha-lipoic acid ameliorates myocardial toxicity induced by doxorubicin. Pharmacol Res 46:499-503 (Pubitemid 35435691)
4. Anderlini P, Benjamin RS, Wong FC, Kantarjian HM, Andreeff M, Kornblau SM, O'Brien S, Mackay B, Ewer MS, Pierce SA (1995) Idarubicin cardiotoxicity: a retrospective study in acute myeloid leukemia and myclodysplasia. J Clin Oncol 11:2827-2834
5. Andrieu-Abadie N, Jaffrezou JP, Hatem S, Laurent G, Levade T, Mercaider JJ (1999) L-Carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: role of inhibition of ceramide generation. FASEB J 13:1501-1510 (Pubitemid 29411782)
6. Brown HR, Ni H, Benavides G, Yoon L, Hyder K, Giridhar J, Gardner G, Tyler RD, Morgan KT (2002) Correlation of simultaneous differential gene expression in the blood and heart with known mechanisms of adriamycin-induced cardiomyopathy in the rat. Toxicol Pathol 30:452-469
7. Choi KM, Lee J, Kim YH, Kim KB, Kim DL, Kim SG, Shin DH, Kim NH, Park IB, Choi DS, Baik SH (2003) Relation between insulin resistance and hematological parameters in elderly Koreans-Southwest Seoul (SWS) Study. Diabetes Res Clin Pract 60:205-212 (Pubitemid 36561623)
8. Cruciani RA, Dvorkin E, Homel P, Culliney B, Malamud S, Shaiova L, Fleishman S, Lapin J, Klein E, Lesage P, Portenoy R, Esteban-Cruciani N (2004) L-Carnitine supplementation for the treatment of fatigue and depressed mood in cancer patients with carnitine deficiency: a preliminary analysis. Ann NY Acad Sci 1033:168-176 (Pubitemid 39656749)
9. Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V (2000) Beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem 275:1699-1707 (Pubitemid 30060789)
10. Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J Biol Chem 272:11369-11377 (Pubitemid 27184141)
11. Gardner JP, Li S, Srinivasan SR, Chen W, Kimura M, Lu X, Berenson GS, Aviv A (2005) Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111:2171-2177 (Pubitemid 40632431)
12. Grynberg A (2005) Effectors of fatty acid oxidation reduction: promising new anti-ischaemic agents. Curr Pharm Des 11:489-509
13. Gurlek A, Tutar E, Akcil E, Dincer I, Erol C, Kocaturk PA, Oral D (2000) The effects of L-carnitine treatment on left ventricular function and erythrocyte superoxide dismutase activity in patients with ischemic cardiomyopathy. Eur J Heart Fail 2:189-193 (Pubitemid 30407560)
14. Hale JP, Lewis IJ (1994) Anthracyclines: cardiotoxicity and its prevention. Arch Dis Child 71:457-462 (Pubitemid 24349861)
15. Haripriya D, Sangeetha P, Kanchana A, Balu M, Panneerselvam C (2005) Modulation of age-associated oxidative DNA damage in rat brain cerebral cortex, striatum and hippocampus by L-carnitine. Exp Gerontol 40:129-135 (Pubitemid 40343003)
16. Hofmann S, Tuchler H, Bernhart M, Stacher A, Lutz D (1993) A questionnaire suitable for general practice for detection of the health status and quality of life of patients with hemato-oncologic diseases: psychometric properties. The Study G "Quality of Life" of the International Society for Chemo- and Immunotherapy (I.G.C.I.). Wien Klin Wochenschr 105:277-283
17. Karlic H, Lohninger S, Koeck T, Lohninger A (2002) Dietary L-carnitine stimulates carnitine acyltransferases in the liver of aged rats. J Histochem Cytochem 50:205-212 (Pubitemid 34106759)
18. Karlic H, Lohninger A, Laschan C, Lapin A, Bohmer F, Huemer M, Guthann E, Rappold E, Pfeilstocker M (2003) Downregulation of carnitine acyltransferases and organic cation transporter OCTN2 in mononuclear cells in healthy elderly and patients with myelodysplastic syndromes. J Mol Med 81:435-442 (Pubitemid 36900539)
19. Karlic H, Lohninger A (2004) Supplementation of L-carnitine in athletes: does it make sense? Nutrition 20:709-715 (Pubitemid 38798089)
20. Kolovou GD, Anagnostopoulou KK, Cokkinos DV (2005) Pathophysiology of dyslipidaemia in the metabolic syndrome. Postgrad Med J 81:358-366 (Pubitemid 40834900)
21. Kraemer WJ, Volek JS, French DN, Rubin MR, Sharman MJ, Gomez AL, Ratamess NA, Newton RU, Jemiolo B, Craig BW, Hakkinen K (2003) The effects of L-carnitine L-tartrate supplementation on hormonal responses to resistance exercise and recovery. J Strength Cond Res 17:455-462
22. Kumaran S, Savitha S, Anusuya Devi M, Panneerselvam C (2004) L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues. Mech Ageing Dev 125:507-512 (Pubitemid 38916609)
23. Kumaran S, Subathra M, Balu M, Panneerselvam C (2005) Supplementation of L-carnitine improves mitochondrial enzymes in heart and skeletal muscle of aged rats. Exp Aging Res 31:55-67 (Pubitemid 40069911)
24. Lamhonwah AM, Skaug J, Scherer SW, Tein I (2003) A third human carnitine/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn's disease locus (IBD5). Biochem Biophys Res Commun 301:98-101 (Pubitemid 36268853)
25. Lefrak EA, Pitha J, Rosenheim S, Gottlieb JA (1973) A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302-314
26. Lohninger A, Preis P, Linhart L, Sommoggy SV, Landau M, Kaiser E (1990) Determination of plasma free fatty acids, free cholesterol, cholesteryl esters, and triacylglycerols directly from total lipid extract by capillary gas chromatography. Anal Biochem 186:243-250 (Pubitemid 20153499)
27. Lohninger A, Hofbauer R, Nissel H, Karlic H (2002) Carnitine and transcription of carnitine palmitoyltransferases - in vitro and in vivo studies. In: Richter RW, Rassoul F, Thiery J (eds) Lipoproteinmetabolismus und Atherosklerosepraevention. Wissenschaftliche Skripten, Leipzig, pp 113-122
28. McFalls EO, Paulson DJ, Gilbert EF, Shug AL (1986) Carnitine protection against adriamycin-induced cardiomyopathy in rats. Life Sci 38:497-505 (Pubitemid 16164023)
29. Mingrone G, Greco AV, Capristo E, Benedetti G, Giancaterini A, De Gaetano A, Gasbarrini G (1999) L-Carnitine improves glucose disposal in type 2 diabetic patients. J Am Coll Nutr 18:77-82 (Pubitemid 29088689)
30. Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185-229 (Pubitemid 38720829)
31. Mutomba MC, Yuan H, Konyavko M, Adachi S, Yokoyama CB, Esser V, McGarry JD, Babior BM, Gottlieb RA (2000) Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine. FEBS Lett 478:19-25 (Pubitemid 30462251)
32. Nakamura T, Ueda Y, Juan Y, Katsuda S, Takahashi H, Koh E (2000) Fas-mediated apoptosis in adriamycin-induced cardiomyopathy in rats: in vivo study. Circulation 102:572-578 (Pubitemid 30639976)
33. Nakashima H, Ozono R, Suyama C, Sueda T, Kambe M, Oshima T (2004) Telomere attrition in white blood cell correlating with cardiovascular damage. Hypertens Res 27:319-325 (Pubitemid 38832671)
34. Olson RD, Mushlin PS (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J 4:3076-3086
35. Paterna S, Furitano G, Scaffidi L, Barbarino C, Campisi D, Parisi G, Carreca I (1984) Effects of L-carnitine on adriamycin-induced cardiomyopathy in rabbit. Int J Tissue React 6:91-95 (Pubitemid 14164096)
36. Paumen MB, Ishida Y, Han H, Muramatsu M, Eguchi Y, Tsujimoto Y, Honjo T (1997a) Direct interaction of the mitochondrial membrane protein carnitine palmitoyltransferase I with Bcl-2. Biochem Biophys Res Commun 231:523-525 (Pubitemid 27217543)
37. Paumen MB, Ishida Y, Muramatsu M, Yamamoto M, Honjo T (1997b) Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J Biol Chem 272:3324-3329
38. Peluso G, Nicolai R, Reda E, Benatti P, Barbarisi A, Calvani M (2000) Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system. J Cell Physiol 182:339-350
39. Pittner F, Lohninger A, Pittner G (2005) 100 Years research on carnitine. Chem Mon 136:1255-1544
40. Quiles JL, Huertas JR, Battino M, Mataix J, Ramirez-Tortosa MC (2002) Antioxidant nutrients and adriamycin toxicity. Toxicology 180:79-95 (Pubitemid 35248094)
41. Quillet-Mary A, Jaffrezou JP, Mansat V, Bordier C, Naval J, Laurent G (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J Biol Chem 272:21388-21395 (Pubitemid 27374008)
42. Rabbani A, Finn RM, Ausio J (2005) The anthracycline antibiotics: antitumor drugs that alter chromatin structure. Bioessays 27:50-56 (Pubitemid 40128622)
43. Ramsay RR, Gandour RD, van der Leij FR (2001) Molecular enzymology of carnitine transfer and transport. Biochim Biophys Acta 1546:21-43 (Pubitemid 32217800)
44. Sayed-Ahmed MM, Shouman SA, Rezk BM, Khalifa MH, Osman AM, El-Merzabani MM (2000) Propionyl-L-carnitine as potential protective agent against adriamycin-induced impairment of fatty acid beta-oxidation in isolated heart mitochondria. Pharmacol Res 41:143-150 (Pubitemid 30670330)
45. Singal PK, Iliskovic N, Li T, Kumar D (1997) Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J 11:931-936 (Pubitemid 27425894)
46. Tuchler H, Hofmann S, Bernhart M, Brugiatelli M, Chrobak L, Franke A, Herold M, Holowiecki J, Ihle R, Jaksic B et al (1992) A short multilingual quality of life questionnaire - practicability, reliability and interlingual homogeneity. Qual Life Res 1:107-117
47. Wagner CA, Lukewille U, Kaltenbach S, Moschen I, Broer A, Risler T, Broer S, Lang F (2000) Functional and pharmacological characterization of human Na(+)-carnitine cotransporter hOCTN2. Am J Physiol Renal Physiol 279:F584-F591
48. Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I (2003) Characterization of organic cation/carnitine transporter family in human sperm. Biochem Biophys Res Commun 306:121-128 (Pubitemid 36629414)
49. Yoon HR, Hong YM, Boriack RL, Bennett MJ (2003) Effect of L-carnitine supplementation on cardiac carnitine palmitoyltransferase activities and plasma carnitine concentrations in adria-mycin-treated rats. Pediatr Res 53:788-792 (Pubitemid 36504722)
50. Zeibig J, Karlic H, Lohninger A, Dumsgaard R, Smekal G (2005) Do blood cells mimic gene expression profile alterations known to occur in muscular adaptation to endurance training ? Eur J Appl Physiol 7 April 2005 [Epub ahead of print]