Safety of incremental inhaled lipopolysaccharide challenge in humans

Journal of Endotoxin Research

Volumn 12, Issue 2, 2006, Pages 113-119

  Sundy, John S ^a   Wood, William A ^b   Watt, Janet L ^c   Kline, Joel N ^c   Schwartz, David A ^a,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Endotoxin; Inhalation challenge; Lipopolysaccharide; Systemic responses

Indexed keywords

IBUPROFEN; INFUSION FLUID; LIPOPOLYSACCHARIDE; PARACETAMOL; SALBUTAMOL;

ADULT; ARTICLE; BLOOD PRESSURE; CHEST TIGHTNESS; CHILL; COUGHING; DRUG SAFETY; DRUG TOLERABILITY; FEVER; HEADACHE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOTENSION; INHALATION TEST; LUNG DISEASE; LUNG FUNCTION TEST; MALAISE; MEAN ARTERIAL PRESSURE; MYALGIA; NORMAL HUMAN; RETROSPECTIVE STUDY; SIDE EFFECT; SYMPTOMATOLOGY; TEMPERATURE MEASUREMENT; ADOLESCENT; BODY TEMPERATURE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ESCHERICHIA COLI; FEMALE; INHALATIONAL DRUG ADMINISTRATION; MALE; MIDDLE AGED; PATHOPHYSIOLOGY;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; BLOOD PRESSURE; BODY TEMPERATURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FEMALE; FEVER; HEART RATE; HUMANS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; RETROSPECTIVE STUDIES;

EID: 33646932054     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/09680519060120020701     Document Type: Article

References (31)

1. Bonner JC, Rice AB, Lindroos PM et al. Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City. Am J Respir Cell Mol Biol 1998; 19: 672-680.
2. Suffredini AF, Hochstein HD, McMahon FG Dose-related inflammatory effects of intravenous endotoxin in humans: Evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. J Infect Dis 1999; 179: 1278-1282.
3. Rylander R., Bake B., Fischer JJ, Helander IM Pulmonary function and symptoms after inhalation of endotoxin. Am Rev Respir Dis 1989; 140: 981-986.
4. Rylander R., Haglind P., Lundholm M. Endotoxin in cotton dust and respiratory function decrement among cotton workers in an experimental cardroom. Am Rev Respir Dis 1985; 131: 209-213.
5. Michel O., Ginanni R., Le Bon B., Content J., Duchateau J., Sergysels R. Inflammatory response to acute inhalation of endotoxin in asthmatic patients. Am Rev Respir Dis 1992; 146: 352-357.
6. Gehring U., Bischof W., Fahlbusch B., Wichmann HE, Heinrich J. House dust endotoxin and allergic sensitization in children. Am J Respir Crit Care Med 2002; 166: 939-944.
7. Braun-Fahrlander C., Riedler J., Herz U. et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med 2002; 347: 869-877.
8. Michel O., Ginanni R., Duchateau J., Vertongen F., Le Bon B., Sergysels R. Domestic endotoxin exposure and clinical severity of asthma. Clin Exp Allergy 1991; 21: 441-448.
9. Michel O., Kips J., Duchateau J. et al. Severity of asthma is related to endotoxin in house dust. Am J Respir Crit Care Med 1996; 154: 1641-1646.
10. Kline JN, Cowden JD, Hunninghake GW et al. Variable airway responsiveness to inhaled lipopolysaccharide. Am J Respir Crit Care Med 1999; 160: 297-303.
11. Clapp WD, Thorne PS, Frees KL, Zhang X., Lux CR, Schwartz DA The effects of inhalation of grain dust extract and endotoxin on upper and lower airways. Chest 1993; 104: 825-830.
12. Arbour NC, Lorenz E., Schutte BC et al. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet 2000; 25: 187-191.
13. Van der Zwan JC, Orie NG, Kauffman HF, Wiers PW, de Vries K. Bronchial obstructive reactions after inhalation with endotoxin and precipitinogens of Haemophilus influenzae in patients with chronic non-specific lung disease. Clin Allergy 1982; 12: 547-559.
14. Michel O., Dentener M., Corazza F., Buurman W., Rylander R. Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy. J Allergy Clin Immunol 2001; 107: 797-804.
15. Alexis NE, Eldridge MW, Peden DB Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11b expression in atopic asthmatic subjects. J Allergy Clin Immunol 2003; 112: 353-361.
16. Thorn J., Rylander R. Inflammatory response after inhalation of bacterial endotoxin assessed by the induced sputum technique. Thorax 1998; 53: 1047-1052.
17. Michel O., LeVan TD, Stern D. et al. Systemic responsiveness to lipopolysaccharide and polymorphisms in the Toll-like receptor 4 gene in human beings. J Allergy Clin Immunol 2003; 112: 923-929.
18. Jamison JP, Lowry RC Bronchial challenge of normal subjects with the endotoxin of Enterobacter agglomerans isolated from cotton dust. Br J Ind Med 1986; 43: 327-331.
19. Michel O., Duchateau J., Sergysels R. Effect of inhaled endotoxin on bronchial reactivity in asthmatic and normal subjects. J Appl Physiol 1989; 66: 1059-1064.
20. Michel O., Ginanni R., Sergysels R. Relation between the bronchial obstructive response to inhaled lipopolysaccharide and bronchial responsiveness to histamine. Thorax 1992; 47: 288-291.
21. Herbert A., Carvalheiro M., Rubenowitz E., Bake B., Rylander R. Reduction of alveolar-capillary diffusion after inhalation of endotoxin in normal subjects. Chest 1992; 102: 1095-1098.
22. Sandstrom T., Bjermer L., Rylander R. Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J 1992; 5: 992-996.
23. Michel O., Ginanni R., Sergysels R. Protective effect of sodium cromoglycate on lipopolysaccharide-induced bronchial obstruction in asthmatics. Int Arch Allergy Immunol 1995; 108: 298-302.
24. Michel O.,. Duchateau J., Plat G. et al. Blood inflammatory response to inhaled endotoxin in normal subjects. Clin Exp Allergy 1995; 25: 73-79.
25. Jagielo PJ, Thorne PS, Watt JL, Frees KL, Quinn TJ, Schwartz DA Grain dust and endotoxin inhalation challenges produce similar inflammatory responses in normal subjects. Chest 1996; 110: 263-270.
26. Rolla G., Bucca C., Brussino L., Dutto L., Colagrande P., Polizzi S. Pentoxifylline attenuates LPS-induced bronchial hyperresponsiveness but not the increase in exhaled nitric oxide. Clin Exp Allergy 1997; 27: 96-103.
27. Michel O., Nagy AM, Schroeven M. et al. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med 1997; 156: 1157-1164.
28. Wesselius LJ, Nelson ME, Bailey K., O'Brien-Ladner AR. Rapid lung cytokine accumulation and neutrophil recruitment after lipopolysaccharide inhalation by cigarette smokers and nonsmokers. J Lab Clin Med 1997; 129: 106-114.
29. Michel O., Olbrecht J., Moulard D., Sergysels R. Effect of antiasthmatic drugs on the response to inhaled endotoxin. Ann Allergy Asthma Immunol 2000; 85: 305-310.
30. Von Essen S, Fryzek J., Nowakowski B., Wampler M. Respiratory symptoms and farming practices in farmers associated with an acute febrile illness after organic dust exposure. Chest 1999; 116: 1452-1458.
31. van Eeden SF, Hogg JC Systemic inflammatory response induced by particulate matter air pollution: The importance of bone-marrow stimulation. J Toxicol Environ Health A 2002; 65: 1597-1613.