Active metabolite of atorvastatin inhibits membrane cholesterol domain formation by an antioxidant mechanism

Journal of Biological Chemistry

Volumn 281, Issue 14, 2006, Pages 9337-9345

  Mason, R Preston ^a,b   Walter, Mary F ^a   Day, Charles A ^a   Jacob, Robert F ^a  

^a ELUCIDA RESEARCH LLC   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; CELL MEMBRANES; CELLS; CHOLESTEROL; METABOLITES; PHOSPHOLIPIDS;

ATHEROSCLEROTIC LESION; LIPOPROTEINS; MEMBRANE CHOLESTEROL DOMAINS; PHENOXY GROUP;

CYTOLOGY;

ATORVASTATIN; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN; POLYUNSATURATED FATTY ACID; PRAVASTATIN; PROBUCOL; ROSUVASTATIN; SIMVASTATIN; TROLOX C; ANTIOXIDANT; HEPTANOIC ACID DERIVATIVE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MEMBRANE LIPID; PYRROLE DERIVATIVE;

ARTICLE; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; X RAY DIFFRACTION; APOPTOSIS; ATHEROSCLEROSIS; BIOLOGICAL MODEL; CELL MEMBRANE; DOSE RESPONSE; HYPERLIPIDEMIA; INFLAMMATION; LIPID PEROXIDATION; METABOLISM; PATHOPHYSIOLOGY;

ANTIOXIDANTS; APOPTOSIS; ATHEROSCLEROSIS; CELL MEMBRANE; CHOLESTEROL, LDL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERLIPIDEMIAS; INFLAMMATION; LIPID PEROXIDATION; MEMBRANE LIPIDS; MODELS, BIOLOGICAL; OXIDATIVE STRESS; PYRROLES; X-RAY DIFFRACTION;

EID: 33646919624     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513000200     Document Type: Article

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