Gene dosage analysis of α-synuclein (SNCA) in patients with Parkinson's disease [3]

Movement Disorders

Volumn 21, Issue 5, 2006, Pages 728-729

  Deng, Hao ^a   Xie, Wenjie ^a   Guo, Y ^b   Le, Weidong ^a   Jankovic, Joseph ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GENOMIC DNA; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ACCURACY; ADULT; AGED; ALTERNATIVE RNA SPLICING; CONTROLLED STUDY; DIPLOIDY; DNA DETERMINATION; DNA EXTRACTION; DNA MODIFICATION; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENE DOSAGE; GENE DUPLICATION; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOCUS; GENE MUTATION; GENETIC HETEROGENEITY; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY; HUMAN; LETTER; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY ANALYSIS;

ADULT; ALPHA-SYNUCLEIN; FEMALE; GENE DOSAGE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 33646913235     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.20860     Document Type: Letter

References (5)

1. Deng H, Le WD, Guo Yi, Hunter CB, Xie WJ, Jankovic J. Genetic and clinical identification of Parkinson's disease patients with LRRK2 G2019S mutation. Ann Neurol 2005;57:933-934.
2. Singleton AB, Farrer M, Johnson J, et al. Alpha-synuclein locus triplication causes Parkinson's disease. Science 2003;302:841.
3. Chartier-Harlin MC, Kachergus J, Roumier C, et al. Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004;364:1167-1169.
4. Gispert S, Trenkwalder C, Mota-Vieira L, Kostic V, Auburger G. Failure to find alpha-synuclein gene dosage changes in 190 patients with familial Parkinson disease. Arch Neurol 2005;62:96-98.
5. Mueller JC, Fuchs J, Hofer A, et al. Multiple regions of alpha-synuclein are associated with Parkinson's disease. Ann Neurol 2005;57:535-541.