Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution

FEBS Letters

Volumn 580, Issue 14, 2006, Pages 3445-3450

  O'Hare, Helen M ^a   Huang, Fanglu ^a   Holding, Andrew ^a   Choroba, Oliver W ^a   Spencer, Jonathan B ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Dioxygenase; Enzyme mechanism; Hydroxyphenylglycine; Non proteinogenic amino acids; Non ribosomal peptide synthesis; Protein engineering

Indexed keywords

4 HYDROXYPHENYLPYRUVATE DIOXYGENASE; HYDROXYMANDELATE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; MUTANT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

CATALYSIS; DIOXYGENASES; DIRECTED MOLECULAR EVOLUTION; LIGASES; MODELS, MOLECULAR; PLASMIDS;

EID: 33646901887     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.05.018     Document Type: Article

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