Recombinant human serum albumin dimer has high blood circulation activity and low vascular permeability in comparison with native human serum albumin

Pharmaceutical Research

Volumn 23, Issue 5, 2006, Pages 882-891

  Matsushita, Sadaharu ^a   Chuang, Victor Tuan Giam ^a,b   Kanazawa, Masanori ^a   Tanase, Sumio ^c   Kawai, Keiichi ^d   Maruyama, Toru ^a   Suenaga, Ayaka ^a   Otagiri, Masaki ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^c KUMAMOTO UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Biodistribution; Human serum albumin; Pharmacokinetic analysis; Recombinant human serum albumin dimer; Vascular permeability

Indexed keywords

CARRAGEENAN; DIMER; HUMAN SERUM ALBUMIN; MONOMER; RECOMBINANT HUMAN SERUM ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD VESSEL PERMEABILITY; BODY FAT; CONFORMATION; CONTROLLED STUDY; DIMERIZATION; DRUG BLOOD LEVEL; EXPERIMENTAL MODEL; GENETIC ENGINEERING; LIVER; MALE; MOUSE; MUSCLE; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; RAT; SKIN; SPECTROSCOPY; STEADY STATE; WESTERN BLOTTING;

ANIMALS; CAPILLARY PERMEABILITY; CARRAGEENAN; CLONING, MOLECULAR; DIMERIZATION; EDEMA; MALE; MICE; PLASMA SUBSTITUTES; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN;

EID: 33646876623     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9933-1     Document Type: Article

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