Mice lacking brain/kidney phosphate-activated glutaminase have impaired glutamatergic synaptic transmission, altered breathing, disorganized goal-directed behavior and die shortly after birth

Journal of Neuroscience

Volumn 26, Issue 17, 2006, Pages 4660-4671

  Masson, Justine ^a,b,e   Darmon, Michèle ^a   Conjard, Agnès ^b   Chuhma, Nao ^e   Ropert, Nicole ^c   Thoby Brisson, Muriel ^c   Foutz, Arthur S ^c   Parrot, Sandrine ^d   Miller, Gretchen M ^f   Jorisch, Renée ^f   Polan, Jonathan ^e,f   Hamon, Michel ^a   Hen, René ^e   Rayport, Stephen ^e,f  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSERM   (France)

^c CNRS   (France)

^d UNIVERSITÉ LYON 1   (France)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

GLS1; Glutamate release; Glutamatergic neurons; Knock out mice; Lethal phenotype; Neonatal behavior; Phosphate activated glutaminase; Respiration; Synaptic transmission

Indexed keywords

CARBON DIOXIDE; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; PHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN METABOLISM; BRAIN STEM; CHEMOSENSITIVITY; CONTROLLED STUDY; DEPOLARIZATION; DISORIENTATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; EXCITATORY POSTSYNAPTIC POTENTIAL; HOMOLOGOUS RECOMBINATION; INSPIRATORY CAPACITY; KIDNEY METABOLISM; MORTALITY; MOUSE; NERVE CELL CULTURE; NERVE POTENTIAL; NEUROTRANSMISSION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY FAILURE; SYNAPTIC TRANSMISSION; TEMPORAL SUMMATION; ANIMAL; BRAIN; BREATHING DISORDER; BREATHING MECHANICS; ENZYMOLOGY; HYPOVENTILATION; KIDNEY; MENTAL DISEASE; METABOLISM; MOTIVATION; MOUSE MUTANT; NERVE TRACT; PATHOPHYSIOLOGY; SURVIVAL RATE;

ANIMALS; ANIMALS, NEWBORN; BRAIN; GLUTAMIC ACID; GLUTAMINASE; GOALS; HYPOVENTILATION; KIDNEY; MENTAL DISORDERS; MICE; MICE, KNOCKOUT; NEURAL PATHWAYS; RESPIRATION DISORDERS; RESPIRATORY MECHANICS; SURVIVAL RATE; SYNAPTIC TRANSMISSION;

EID: 33646852395     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4241-05.2006     Document Type: Article

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