Metabolic flux analysis as a tool for the elucidation of the metabolism of neurotransmitter glutamate

Metabolic Engineering

Volumn 5, Issue 3, 2003, Pages 201-210

  Chatziioannou, Aristotle ^a   Palaiologos, Georgios ^b   Kolisis, Fragiskos N ^a  

^a NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0141573235     PISSN: 10967176     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1096-7176(03)00029-6     Document Type: Article

References (19)

1. Daae, E.B., Ison, A.P., 1999. Classification and sensitivity analysis of a proposed primary metabolic reaction network for Streptomyces lividans. Metab. Eng. 1, 153-165.
2. Danbolt, N.C., 2001. Glutamate uptake. Prog. Neurobiol. 65, 1-105.
3. Dennis, S.C., Clark, J.B., 1978. The regulation of glutamate metabolism by tricarboxylic acid-cycle activity in rat brain mitochondria. Biochem. J. 172, 155-162.
4. Fonnum, F., 1984. Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 1-11.
5. 3H]asparate release from rat cerebral cortex. Neurochem Res. 20, 45-49.
6. Ioannou, N., Georgopoulos, A., Liapi, C., Palaiologos, G., 1998. Determination of glutamate by high-performance liquid chromatography with fluorescence detection in superfusates of rat brain preparations. Anal. Biochem. 264, 82-86.
7. +-evoked glutamate release from rat hippocampal slices. Neurochem. Res. 28, 875-881.
8. Mason, G.F., Rothman, D.L., Behar, K.L., Shulman, R.G., 1992a. NMR determination of the TCA cycle rate and a-ketoglutarate/glutamate exchange rate in rat brain. J. Cereb. Blood Flow Metab. 12, 434-447.
9. Mason, G.F., Behar, K.L., Rothman, D.L., Shulman, R.G., 1992b. NMR determination of intracerebral glucose concentration and transport kinetics in rat brain. J. Cereb. Blood Flow Metab. 12, 448-455.
10. Nicholls, D.G., 1989. Release of glutamate, aspartate and γ-aminoboutiric acid from isolated nerve terminals. J. Neurochem. 52, 331-341.
11. Palaiologos, G., Hertz, L., Schousboe, A., 1989. Role of aspartate aminotransferase and mitochondrial dicarboxylate transport for release of endogenously and exogenously supplied neurotransmitter in glutamatergic neurons. Neurochem. Res. 14, 359-366.
12. Raiteri, M., Angelini, F., Levi, G., 1974a. A simple apparatus for studying the release of neurotransmitters from synaptosomes. Eur. J. Pharmacol. 25, 411-414.
13. Raiteri, M., Levi, G., Federico, R., 1974b. d-Amphetamine and the release of 3H-norepinephrine from synaptosomes. Eur. J. Pharmacol. 28, 237-240.
14. 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc. Natl. Acad. Sci. USA 94, 2699-2704.
15. Sibson, N.R., Dhankhar, A., Mason, G.F., Rothman, D.L., Behar, K.L., Schulman, R.G., 1998. Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc. Natl. Acad. Sci. USA 95, 316-321.
16. Stephanopoulos, G.N., Aristidou, A.A., Nielsen, J., 1998. Metabolic Engineering. Principles and Methodologies. Academic Press, London, UK.
17. Svarna, R., Georgopoulos, A., Palaiologos, G., 1996. Determination of glutamate by high-performance liquid chromatography with fluoresence detection in superfusates of rat brain preparations. Neurochem. Res. 21, 603-608.
18. van der Heijden, R.T.J.M., Heijnen, J.J., Hellinga, C., Romein, B., Lyuben, K.Ch.A.M., 1994a. Linear constraint relations in biochemical reaction systems: I. Classification of the calculability and the balanceability of conversion rates. Biotechnol. Bioeng. 43, 3-10.
19. van der Heijden, R.T.J.M., Heijnen, J.J., Hellinga, C., Romein, B., Lyuben, K.Ch.A.M., 1994b. Linear constraint relations in biochemical reaction systems: II. Diagnosis and estimation of gross errors. Biotechnol. Bioeng. 43, 11-20.