Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 13, 2006, Pages 3590-3594

  Majumdar, Susruta ^a   Sloan, Kenneth B ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

6MP; APAP; Dermal delivery; NANAOCAM; NArNAOCAM; Prodrugs; Th

Indexed keywords

BUFFER; IMIDE; MERCAPTOPURINE; PARACETAMOL DERIVATIVE; PHENOL DERIVATIVE; PRODRUG; THEOPHYLLINE; THIOL DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; DRUG PENETRATION; DRUG SYNTHESIS; HYDROLYSIS; IN VITRO STUDY; SKIN PERMEABILITY;

ADMINISTRATION, CUTANEOUS; DRUG DELIVERY SYSTEMS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; IMIDES; MOLECULAR STRUCTURE; PHENOLS; PRODRUGS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS;

EID: 33646836446     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.03.061     Document Type: Article

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8. 4 and then concentrated to an oil which was purified by crystallization or column chromatography.
9. Majumdar, S.; Sloan, K. B. Synth. Commun. submitted for publication.
10. 4).
11. t)) versus time.
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