Two-step synthetic approach to 6-substituted pyrido[2,3-d]pyrimidine(1H,3H) -2,4-diones from 6-amino-, 6-alkylamino-, and 6-arylamino-1,3-dimethyluracils

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

Volumn 61, Issue 4, 2006, Pages 486-494

  Bischoff, Kerstin ^a   Girreser, Ulrich ^a   Heber, Dieter ^a   Schütt, Martin ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

6 Amino 1,3 dimethyluracil; Cyclization; Ene Reaction; Mannich Bases; Pyrido 2,3 d pyrimidines

Indexed keywords

CONDENSATION; CYCLIZATION;

6-AMINO-1,3-DIMETHYLURACIL; ENE REACTION; MANNICH BASIS; MANNICH REACTIONS; PYRIDO[2,3-D] PYRIMIDINES; REACTION CONDITIONS; RING CLOSURES; SYNTHETIC APPROACH;

AROMATIC COMPOUNDS;

EID: 33646831469     PISSN: 09320776     EISSN: None     Source Type: Journal    
DOI: 10.1515/znb-2006-0415     Document Type: Conference Paper

References (14)

1. R. Troschütz, H.J. Roth, Arch. Pharm. (Weinheim) 311, 406 (1978).
2. B. Brinker, D. Heber, Arch. Pharm. (Weinheim) 320, 520 (1987).
3. J.C. Warner, in T. Delia, (Ed.): Miscellaneous Fused Pyrimidines, Vol. 99, p. 17-117; part IV, Wiley, New York (1992).
4. M. Kiesel, E. Haug, W. Kantlehner, J. Prakt. Chem. 339, 159 (1997).
5. K. Goeflitzer, K. Diers, Pharmazie 52, 97 (1997).
6. K. Hirota, K. Kubo, H. Sajiki, Y. Kitade, M. Sako, Y. Maki, J. Org. Chem. 62, 2999 (1997).
7. K. Singh, J. Singh, H. Singh, Tetrahedron 54, 935 (1998).
8. U. Girreser, D. Heber, M. Schütt, Tetrahedron 60, 11511 (2004).
9. U. Wamhoff, L. Lichtenthaeler, Chem. Ber. 111, 2297 (1978).
10. J.I. Borrell, J. Teixido, B. Martinez-Teipel, J.I. Matallana, M.T. Copete, A. Llimargas, E. Garcia, J. Med. Chem. 41, 3539 (1998).
11. J. Bulicz, D.C.G. Bertarella, D. Baumert, F. Fülle, C.E. Müller, D. Heber, Bioorg. Med. Chem., in press.
12. W. Pfleiderer, K.-H. Schündehütte, Liebigs Ann. Chem. 612, 158 (1958).
13. H. Goldner, G. Dietz, E. Carstens, Liebigs Ann. Chem. 691, 142 (1966).
14. H. Goldner, G. Dietz, E. Carstens, Liebigs Ann. Chem. 694, 142 (1966).