Synthesis of 6-substituted 7-aryl-5,6-dihydropyrido[2,3-d]pyrimidine(1H,3H) -2,4-diones using the Vilsmeier reaction

Tetrahedron

Volumn 60, Issue 50, 2004, Pages 11511-11517

  Girreser, Ulrich ^a   Heber, Dieter ^a   Schütt, Martin ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

6 Amino 1,3 dimethyluracil; Cyclization; Cyclocondensation; Mannich bases; Pyrido 2,3 d pyrimidines; Vilsmeier reaction

Indexed keywords

ALDEHYDE; ALKENE DERIVATIVE; MANNICH BASE; PYRIMIDINONE DERIVATIVE; URACIL DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VILSMEIER REACTION;

EID: 8644286300     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.09.075     Document Type: Article

References (11)

1. Preliminary report: Girreser, U.; Heber, D.; Schütt, M. Fifth Electronic Symposium on Organic Synthesis (ECSOC 5), 2001, A0008.
2. J.C. Warner T. Delia Miscellaneous Fused Pyrimidines Vol. 99 1992 Wiley New York 17 117 Part IV
3. R. Troschütz, and H.J. Roth Arch. Pharm. 311 1978 406 414
4. M. Kiesel, E. Haug, and W. Kantlehner J. Prakt. Chem. 339 1997 159 170
5. K. Görlitzer, and K. Diers Pharmazie 52 1997 97 100
6. K. Hirota, K. Kubo, H. Sajiki, Y. Kitade, M. Sako, and Y. Maki J. Org. Chem. 62 1997 2999 3001
7. K. Singh, J. Singh, and H. Singh Tetrahedron 54 1998 935 942
8. J. Quiroga, H. Insuasty, B. Insuasty, R. Abonia, A.S. Cobo, and M. Nogueras Tetrahedron 58 2002 4873 4877
9. H. Wamhoff, and L. Lichtenthaeler Chem. Ber. 111 1978 2297 2306
10. J.L. Borrell, J. Teixido, B. Martinez-Teipel, J.I. Matallana, M.T. Copete, A. Llimargas, and E. Garcia J. Med. Chem. 41 1998 3539 3545
11. H.J. Böhm, G. Klebe, and H. Kubinyi Wirkstoffdesign, der Weg zum Arzneimittel 1996 Spektrum Akademischer Verlag Heidelberg