Synthesis and biological activity of 4-amino-7-oxo-substituted analogoues of 5-Deaza-5,6,7,8-tetrahydrofolic acid and 5,10-dideaza-5,6,7,8- tetrahydrofolic acid

Journal of Medicinal Chemistry

Volumn 41, Issue 18, 1998, Pages 3539-3545

  Borrell, J I ^a   Teixido, J ^a   Martinez Teipel, B ^a   Metallana, J L ^a   Copete, M T ^a   Llimargas, A ^a   Gracia, E ^a  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

5 DEAZA 5,6,7,8 TETRAHYDROFOLIC ACID DERIVATIVE; FOLIC ACID; FOLIC ACID ANTAGONIST; LOMETREXOL; TETRAHYDROFOLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; STRUCTURE ACTIVITY RELATION;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DRUG SCREENING ASSAYS, ANTITUMOR; FOLIC ACID ANTAGONISTS; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATES; TUMOR CELLS, CULTURED;

EID: 0032572817     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9801298     Document Type: Article

References (29)