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Volumn 13, Issue 2, 2006, Pages 93-98

Essential thrombocythemia: Scientific advances and current practice

Author keywords

Diagnosis; Hydroxyurea; JAK2; Thrombocythemia; Treatment

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA INTERFERON; ANAGRELIDE; ANTITHROMBOCYTIC AGENT; HEMOGLOBIN; HYDROXYUREA; JANUS KINASE 2; PIPOBROMAN;

EID: 33646786143     PISSN: 10656251     EISSN: 15317048     Source Type: Journal    
DOI: 10.1097/01.moh.0000208470.86732.b4     Document Type: Review
Times cited : (30)

References (48)
  • 1
    • 34347132671 scopus 로고
    • Hemorrhagic thrombocythemia with a vascular, sclerotic spleen
    • Epstein E, Goedel A. Hemorrhagic thrombocythemia with a vascular, sclerotic spleen [in German]. Virchows Archiv A Pathol Anat Histopathol 1934; 293:233.
    • (1934) Virchows Archiv A Pathol Anat Histopathol , vol.293 , pp. 233
    • Epstein, E.1    Goedel, A.2
  • 2
    • 0001639195 scopus 로고
    • Some speculations on the myeloproliferative syndromes
    • Dameshek W. Some speculations on the myeloproliferative syndromes. Blood 1951; 6:372-375.
    • (1951) Blood , vol.6 , pp. 372-375
    • Dameshek, W.1
  • 3
    • 0001439494 scopus 로고
    • Hemorrhagic thrombocythemia: A critical review
    • Gunz FW. Hemorrhagic thrombocythemia: a critical review. Blood 1960; 15:706-723.
    • (1960) Blood , vol.15 , pp. 706-723
    • Gunz, F.W.1
  • 4
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson PJ, et al. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood 1981; 58:916-919.
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, P.J.3
  • 5
    • 30844456807 scopus 로고    scopus 로고
    • WHO histological classification of chronic myeloproliferative diseases
    • Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Lyon, France: International Agency for Research on Cancer (IARC) Press
    • Vardiman JW, Brunning RD, Harris NL. WHO histological classification of chronic myeloproliferative diseases. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. World Health Organization classification of tumours: tumours of the haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer (IARC) Press; 2001. pp. 17-44.
    • (2001) World Health Organization Classification of Tumours: Tumours of the Haematopoietic and Lymphoid Tissues , pp. 17-44
    • Vardiman, J.W.1    Brunning, R.D.2    Harris, N.L.3
  • 6
    • 0141574207 scopus 로고    scopus 로고
    • The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis
    • Ruggeri M, Tosetto A, Frezzato M, Rodeghiero F. The rate of progression to polycythemia vera or essential thrombocythemia in patients with erythrocytosis or thrombocytosis. Ann Intern Med 2003; 139:470-475.
    • (2003) Ann Intern Med , vol.139 , pp. 470-475
    • Ruggeri, M.1    Tosetto, A.2    Frezzato, M.3    Rodeghiero, F.4
  • 7
    • 6844261163 scopus 로고    scopus 로고
    • Should a platelet limit of 600 x 10(9)/l be used as a diagnostic criterion in essential thrombocythaemia? An analysis of the natural course including early stages
    • Lengfelder E, Hochhaus A, Kronawitter U, et al. Should a platelet limit of 600 x 10(9)/l be used as a diagnostic criterion in essential thrombocythaemia? An analysis of the natural course including early stages. Br J Haematol 1998; 100:15-23.
    • (1998) Br J Haematol , vol.100 , pp. 15-23
    • Lengfelder, E.1    Hochhaus, A.2    Kronawitter, U.3
  • 8
    • 0033917890 scopus 로고    scopus 로고
    • Diagnosis of essential thrombocythemia at platelet counts between 400 and 600 x 10(9)/L.
    • Gruppo Italiano Malattie Mieloproliferative Croniche(GIMMC)
    • Sacchi S, Vinci G, Gugliotta L, et al. Diagnosis of essential thrombocythemia at platelet counts between 400 and 600 x 10(9)/L. Gruppo Italiano Malattie Mieloproliferative Croniche(GIMMC) Haematologica 2000; 85:492-495.
    • (2000) Haematologica , vol.85 , pp. 492-495
    • Sacchi, S.1    Vinci, G.2    Gugliotta, L.3
  • 9
    • 0033555392 scopus 로고    scopus 로고
    • A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications
    • Harrison CN, Gale RE, Machin SJ, Linch DC. A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications. Blood 1999; 93:417-424.
    • (1999) Blood , vol.93 , pp. 417-424
    • Harrison, C.N.1    Gale, R.E.2    Machin, S.J.3    Linch, D.C.4
  • 10
    • 27144443646 scopus 로고    scopus 로고
    • Clinical implications of the JAK2 V617F mutation in essential thrombocythemia
    • Antonioli E, Guglielmelli P, Pancrazzi A, et al. Clinical implications of the JAK2 V617F mutation in essential thrombocythemia. Leukemia 2005; 19:1847-1849. An important study that demonstrated molecular evidence of clonality in essential thrombocythemia considered to be 'polyclonal' by X-linked clonality assays.
    • (2005) Leukemia , vol.19 , pp. 1847-1849
    • Antonioli, E.1    Guglielmelli, P.2    Pancrazzi, A.3
  • 11
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • V617F-induced erythrocytosis in mice.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 12
    • 21344444103 scopus 로고    scopus 로고
    • The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: Status report and immediate implications for disease classification and diagnosis
    • Tefferi A, Gilliland DG. The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis. Mayo Clin Proc 2005; 80:947-958.
    • (2005) Mayo Clin Proc , vol.80 , pp. 947-958
    • Tefferi, A.1    Gilliland, D.G.2
  • 13
    • 0038371050 scopus 로고    scopus 로고
    • Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain
    • Saharinen P, Vihinen M, Silvennoinen O. Autoinhibition of Jak2 tyrosine kinase is dependent on specific regions in its pseudokinase domain. Mol Biol Cell 2003; 14:1448-1459.
    • (2003) Mol Biol Cell , vol.14 , pp. 1448-1459
    • Saharinen, P.1    Vihinen, M.2    Silvennoinen, O.3
  • 14
    • 25844432737 scopus 로고    scopus 로고
    • Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2
    • V617F as it pertains to global as well as specific gene expression characteristics in polycythemia vera.
    • (2005) Blood , vol.106 , pp. 3374-3376
    • Kralovics, R.1    Teo, S.S.2    Buser, A.S.3
  • 15
    • 25844461158 scopus 로고    scopus 로고
    • The Jak2V617F mutation, PRV-1 overexpression and EEC formation define a similar cohort of MPD patients
    • Goerttler PS, Steimle C, Marz E, et al. The Jak2V617F mutation, PRV-1 overexpression and EEC formation define a similar cohort of MPD patients. Blood 2005; 106:2862-2864.
    • (2005) Blood , vol.106 , pp. 2862-2864
    • Goerttler, P.S.1    Steimle, C.2    Marz, E.3
  • 16
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both 'atypical' myeloproliferative disorders and myelodysplastic syndromes
    • V617F in MDS and atypical MPDs.
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3
  • 17
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • V617F in atypical MPDs.
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3
  • 18
    • 27244432586 scopus 로고    scopus 로고
    • Mutation studies in CD3+, CD19+, and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2V617F in granulocytes
    • V617F-associated clonal myeloproliferation. The study also confirms previous observations regarding the absence of the mutant molecule in T lymphocytes.
    • (2005) Br J Haematol , vol.130 , pp. 797-799
    • Lasho, T.L.1    Mesa, R.2    Gilliland, D.G.3    Tefferi, A.4
  • 19
    • 25844518265 scopus 로고    scopus 로고
    • The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia
    • Levine RL, Loriaux M, Huntly BJ, et al. The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 2005; 106:3377-3379.
    • (2005) Blood , vol.106 , pp. 3377-3379
    • Levine, R.L.1    Loriaux, M.2    Huntly, B.J.3
  • 20
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome negative CML and megakaryocytic leukemia
    • Jelinek J, Oki Y, Gharibyan V, et al. JAK2 mutation 1849G > T is rare in acute leukemias but can be found in CMML, Philadelphia-chromosome negative CML and megakaryocytic leukemia. Blood 2005; 106:3370-3373.
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3
  • 21
    • 27744606173 scopus 로고    scopus 로고
    • JAK2 V617F mutation in essential thrombocythemia: Clinical associations and long-term prognostic relevance
    • V617F in essential thrombocythemia. The study showed that patients with the mutation display higher hemoglobin and leukocyte counts but they are not at more risk for either thrombosis or transformation into acute leukemia or myelofibrosis.
    • (2005) Br J Haematol , vol.131 , pp. 208-213
    • Wolanskyj, A.P.1    Lasho, T.L.2    Schwager, S.M.3
  • 22
    • 0036376905 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic aspects of essential thrombocythemia
    • Steensma DP, Tefferi A. Cytogenetic and molecular genetic aspects of essential thrombocythemia. Acta Haematol 2002; 108:55-65.
    • (2002) Acta Haematol , vol.108 , pp. 55-65
    • Steensma, D.P.1    Tefferi, A.2
  • 23
    • 4344575770 scopus 로고    scopus 로고
    • Philadelphia (Ph) chromosome-positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood: Natural history and diagnostic differentiation from Ph-negative essential thrombocythemia
    • Michiels JJ, Berneman Z, Schroyens W, et al. Philadelphia (Ph) chromosome-positive thrombocythemia without features of chronic myeloid leukemia in peripheral blood: natural history and diagnostic differentiation from Ph-negative essential thrombocythemia. Ann Hematol 2004; 83:504-512.
    • (2004) Ann Hematol , vol.83 , pp. 504-512
    • Michiels, J.J.1    Berneman, Z.2    Schroyens, W.3
  • 24
    • 0036118751 scopus 로고    scopus 로고
    • Typical essential thrombocythaemia does not express bcr-abelson fusion transcript
    • Damaj G, Delabesse E, Le Bihan C, et al. Typical essential thrombocythaemia does not express bcr-abelson fusion transcript. Br J Haematol 2002; 116:812-816.
    • (2002) Br J Haematol , vol.116 , pp. 812-816
    • Damaj, G.1    Delabesse, E.2    Le Bihan, C.3
  • 25
    • 13444256042 scopus 로고    scopus 로고
    • Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia
    • Elliott MA, Tefferi A. Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia. Br J Haematol 2005; 128:275-290.
    • (2005) Br J Haematol , vol.128 , pp. 275-290
    • Elliott, M.A.1    Tefferi, A.2
  • 26
    • 2942579910 scopus 로고    scopus 로고
    • Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation
    • Barbui T, Barosi G, Grossi A, et al. Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation. Haematologica 2004; 89:215-232.
    • (2004) Haematologica , vol.89 , pp. 215-232
    • Barbui, T.1    Barosi, G.2    Grossi, A.3
  • 27
    • 17844390356 scopus 로고    scopus 로고
    • Leukocyte-platelet interaction in patients with essential thrombocythemia and polycythemia vera
    • Falanga A, Marchetti M, Vignoli A, et al. Leukocyte-platelet interaction in patients with essential thrombocythemia and polycythemia vera. Exp Hematol 2005; 33:523-530. A study that incriminates neutrophils as being thrombogenic in essential thrombocythemia.
    • (2005) Exp Hematol , vol.33 , pp. 523-530
    • Falanga, A.1    Marchetti, M.2    Vignoli, A.3
  • 28
    • 0028913012 scopus 로고
    • Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis
    • Cortelazzo S, Finazzi G, Ruggeri M, et al. Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis. N Engl J Med 1995; 332:1132-1136.
    • (1995) N Engl J Med , vol.332 , pp. 1132-1136
    • Cortelazzo, S.1    Finazzi, G.2    Ruggeri, M.3
  • 29
    • 21444434751 scopus 로고    scopus 로고
    • Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia
    • Harrison CN, Campbell PJ, Buck G, et al. Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia. N Engl J Med 2005; 353:33-45. The largest randomized study in essential thrombocythemia proves the superiority of hydroxyurea over anagrelide, both in combination with aspirin, in the treatment of high-risk essential thrombocythemia. The study showed that hydroxyurea combined with low-dose aspirin was associated with a lesser risk of arterial thrombosis, major hemorrhage, and transformation into myelofibrosis.
    • (2005) N Engl J Med , vol.353 , pp. 33-45
    • Harrison, C.N.1    Campbell, P.J.2    Buck, G.3
  • 30
    • 0028809443 scopus 로고
    • Increased thromboxane biosynthesis in essential thrombocythemia
    • Rocca B, Ciabattoni G, Tartaglione R, et al. Increased thromboxane biosynthesis in essential thrombocythemia. Thromb Haemost 1995; 74:1225-1230.
    • (1995) Thromb Haemost , vol.74 , pp. 1225-1230
    • Rocca, B.1    Ciabattoni, G.2    Tartaglione, R.3
  • 31
    • 1542358995 scopus 로고    scopus 로고
    • Pathophysiology and treatment of platelet-mediated microvascular disturbances, major thrombosis and bleeding complications in essential thrombocythaemia and polycythaemia vera
    • Michiels JJ, Berneman ZN, Schroyens W, Van Vliet HH. Pathophysiology and treatment of platelet-mediated microvascular disturbances, major thrombosis and bleeding complications in essential thrombocythaemia and polycythaemia vera. Platelets 2004; 15:67-84.
    • (2004) Platelets , vol.15 , pp. 67-84
    • Michiels, J.J.1    Berneman, Z.N.2    Schroyens, W.3    Van Vliet, H.H.4
  • 32
    • 0021683781 scopus 로고
    • Acquired von Willebrand's disease in the myeloproliferative syndrome
    • Budde U, Schaefer G, Mueller N, et al. Acquired von Willebrand's disease in the myeloproliferative syndrome. Blood 1984; 64:981-985.
    • (1984) Blood , vol.64 , pp. 981-985
    • Budde, U.1    Schaefer, G.2    Mueller, N.3
  • 33
    • 8344229870 scopus 로고    scopus 로고
    • Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia
    • Passamonti F, Rumi E, Pungolino E, et al. Life expectancy and prognostic factors for survival in patients with polycythemia vera and essential thrombocythemia. Am J Med 2004; 117:755-761. A large study with many helpful pieces of information about the natural history of essential thrombocythemia.
    • (2004) Am J Med , vol.117 , pp. 755-761
    • Passamonti, F.1    Rumi, E.2    Pungolino, E.3
  • 34
    • 0035062679 scopus 로고    scopus 로고
    • A single institutional experience with 43 pregnancies in essential thrombocythemia
    • Wright CA, Tefferi A. A single institutional experience with 43 pregnancies in essential thrombocythemia. Eur J Haematol 2001; 66:152-159.
    • (2001) Eur J Haematol , vol.66 , pp. 152-159
    • Wright, C.A.1    Tefferi, A.2
  • 35
    • 21344460229 scopus 로고    scopus 로고
    • How to interpret and pursue an abnormal complete blood cell count in adults
    • Tefferi A, Hanson CA, Inwards DJ. How to interpret and pursue an abnormal complete blood cell count in adults. Mayo Clin Proc 2005; 80:923-936.
    • (2005) Mayo Clin Proc , vol.80 , pp. 923-936
    • Tefferi, A.1    Hanson, C.A.2    Inwards, D.J.3
  • 36
    • 0141506861 scopus 로고    scopus 로고
    • The myelodysplastic/myeloproliferative disorders: The interface
    • Bennett JM. The myelodysplastic/myeloproliferative disorders: the interface. Hematol Oncol Clin North Am 2003; 17:1095-1100.
    • (2003) Hematol Oncol Clin North Am , vol.17 , pp. 1095-1100
    • Bennett, J.M.1
  • 37
    • 0032942254 scopus 로고    scopus 로고
    • Clinicopathological diagnosis and differential criteria of thrombocythemias in various myeloproliferative disorders by histopathology, histochemistry and immunostaining from bone marrow biopsies
    • Thiele J, Kvasnicka HM, Diehl V, et al. Clinicopathological diagnosis and differential criteria of thrombocythemias in various myeloproliferative disorders by histopathology, histochemistry and immunostaining from bone marrow biopsies. Leukemia Lymphoma 1999; 33:207-218.
    • (1999) Leukemia Lymphoma , vol.33 , pp. 207-218
    • Thiele, J.1    Kvasnicka, H.M.2    Diehl, V.3
  • 38
    • 0025820104 scopus 로고
    • Life expectancy of patients with chronic nonleukemic myeloproliferative disorders
    • Rozman C, Giralt M, Feliu E, et al. Life expectancy of patients with chronic nonleukemic myeloproliferative disorders. Cancer 1991; 67:2658-2663.
    • (1991) Cancer , vol.67 , pp. 2658-2663
    • Rozman, C.1    Giralt, M.2    Feliu, E.3
  • 39
    • 33646795502 scopus 로고    scopus 로고
    • Essential thrombocythemia: Beyond the first decade
    • Wolanskyj AP, Segovis CM, Schwager SM, et al. Essential thrombocythemia: beyond the first decade. Blood 2003; 102:920a.
    • (2003) Blood , vol.102
    • Wolanskyj, A.P.1    Segovis, C.M.2    Schwager, S.M.3
  • 40
    • 0031728928 scopus 로고    scopus 로고
    • No treatment for low-risk thrombocythaemia: Results from a prospective study
    • Ruggeri M, Finazzi G, Tosetto A, et al. No treatment for low-risk thrombocythaemia: results from a prospective study. Br J Haematol 1998; 103:772-777.
    • (1998) Br J Haematol , vol.103 , pp. 772-777
    • Ruggeri, M.1    Finazzi, G.2    Tosetto, A.3
  • 41
    • 24944520130 scopus 로고    scopus 로고
    • Essential thrombocythaemia: Challenges and evidence-based management
    • Harrison CN. Essential thrombocythaemia: challenges and evidence-based management. Br J Haematol 2005; 130:153-165.
    • (2005) Br J Haematol , vol.130 , pp. 153-165
    • Harrison, C.N.1
  • 42
    • 5644298757 scopus 로고    scopus 로고
    • PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia
    • Vannucchi AM, Grossi A, Pancrazzi A, et al. PRV-1, erythroid colonies and platelet Mpl are unrelated to thrombosis in essential thrombocythaemia. Br J Haematol 2004; 127:214-219.
    • (2004) Br J Haematol , vol.127 , pp. 214-219
    • Vannucchi, A.M.1    Grossi, A.2    Pancrazzi, A.3
  • 43
    • 0034993370 scopus 로고    scopus 로고
    • Clonal hemopoiesis and risk of thrombosis in young female patients with essential thrombocythemia
    • Chiusolo P, La Barbera EO, Laurenti L, et al. Clonal hemopoiesis and risk of thrombosis in young female patients with essential thrombocythemia. Exp Hematol 2001; 29:670-676.
    • (2001) Exp Hematol , vol.29 , pp. 670-676
    • Chiusolo, P.1    La Barbera, E.O.2    Laurenti, L.3
  • 44
    • 14344262558 scopus 로고    scopus 로고
    • Clonality analysis by HUMARA assay in Spanish females with essential thrombocythemia and polycythemia vera
    • Zamora L, Espinet B, Florensa L, et al. Clonality analysis by HUMARA assay in Spanish females with essential thrombocythemia and polycythemia vera. Haematologica 2005; 90:259-261.
    • (2005) Haematologica , vol.90 , pp. 259-261
    • Zamora, L.1    Espinet, B.2    Florensa, L.3
  • 45
    • 0025213422 scopus 로고
    • Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia
    • Cortelazzo S, Viero P, Finazzi G, et al. Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia. J Clin Oncol 1990; 8:556-562.
    • (1990) J Clin Oncol , vol.8 , pp. 556-562
    • Cortelazzo, S.1    Viero, P.2    Finazzi, G.3
  • 46
    • 0035865604 scopus 로고    scopus 로고
    • Long-term use of anagrelide in young patients with essential thrombocythemia
    • Storen EC, Tefferi A. Long-term use of anagrelide in young patients with essential thrombocythemia. Blood 2001; 97:863-866.
    • (2001) Blood , vol.97 , pp. 863-866
    • Storen, E.C.1    Tefferi, A.2
  • 47
    • 0030707621 scopus 로고    scopus 로고
    • Thrombotic complications in essential thrombocythemia with relatively low platelet counts
    • Regev A, Stark P, Blickstein D, Lahav M. Thrombotic complications in essential thrombocythemia with relatively low platelet counts. Am J Hematol 1997; 56:168-172.
    • (1997) Am J Hematol , vol.56 , pp. 168-172
    • Regev, A.1    Stark, P.2    Blickstein, D.3    Lahav, M.4
  • 48
    • 0031047229 scopus 로고    scopus 로고
    • Interferon alfa: Effects of long-term treatment for polycythemia vera
    • Silver RT. Interferon alfa: effects of long-term treatment for polycythemia vera. Semin Hematol 1997; 34:40-50.
    • (1997) Semin Hematol , vol.34 , pp. 40-50
    • Silver, R.T.1


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