Arachidonate 5-lipoxygenase variants in atherosclerosis, obesity, and bone traits

Circulation Research

Volumn 98, Issue 8, 2006, Pages

  Lyons, Malcolm A ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALOX5 PROTEIN; ARACHIDONATE 5 LIPOXYGENASE; GENE PRODUCT; ISOLEUCINE; UNCLASSIFIED DRUG; VALINE;

ALLELISM; ALOX5 GENE; AMINO ACID SUBSTITUTION; ATHEROSCLEROSIS; BONE TRAIT; GENE; GENE FUNCTION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; KNOCKOUT GENE; KNOCKOUT MOUSE; LETTER; MORPHOLOGICAL TRAIT; NONHUMAN; OBESITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS;

ALLELES; ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; ARTERIOSCLEROSIS; BONE DISEASES; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; OBESITY; QUANTITATIVE TRAIT LOCI; VARIATION (GENETICS);

EID: 33646780619     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000219674.81938.63     Document Type: Letter

References (7)

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2. Mehrabian M, Wong J, Wang X, Jiang Z, Shi W, Fogelman AM, Lusis AJ. Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res. 2001;89:125-130.
3. Kuhn H, Anton M, Gerth C, Habenicht A. Amino acid differences in the deduced 5-lipoxygenase sequence of cast atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog. Arterioscler Thromb Vasc Biol. 2003;23:1072-1076.
4. Lyons MA, Wittenburg H, Li R, Walsh K, Leonard MR, Churchill GA, Carey MC, Paigen B. New quantitative trait loci that contribute to cholesterol gallstone formation detected in an intercross of CAST/Ei and 129S1/SvImJ inbred mice. Physiol Genomics. 2003;14:225-239.
5. Lyons MA, Wittenburg H, Li R, Walsh K, Churchill GA, Carey MC, Paigen B. Quantitative trait loci that determine lipoprotein cholesterol levels in DBA/2J and CAST/Ei inbred mice. J Lipid Res. 2003;44:953-967.
6. Lyons MA, Wittenburg H, Li R, Walsh K, Leonard MR, Korstanje R, Churchill GA, Carey MC, Paigen B. Lith6: A new QTL for cholesterol gallstones from an intercross of CAST/Ei and DBA/2J inbred mouse strains. J Lipid Res. 2003;44:1763-1771.
7. Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet. 2005;37:1224-1233.