Nonsteroidal progesterone receptor ligands (II); synthesis and SAR of new tetrahydrobenzindolone derivatives

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 14, 2006, Pages 4862-4878

  Kurihara, Ken ichi ^a   Shinei, Rie ^a   Tanabe, Kiyoshi ^a   Tabata, Yuji ^a   Kurata, Yasushi ^a   Hoshiko, Shigeru ^a   Okonogi, Tsuneo ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Nonsteroidal progesterone receptor ligand; PF1092; Tetrahydrobenzindolone; Tetrahydronaphthofuranone

Indexed keywords

7 METHOXY 6 (3 METHYLBUTOXY) 4A,5,6,7 TETRAHYDRO 1,3,4A,5 TETRAMETHYLBENZ[F]INDOL 2(4H) ONE; 7 METHOXY 6 N,N DIMETHYLCARBAMOYLOXY 4A,5,6,7 TETRAHYDRO 1,3,4A,5 TETRAMETHYLBENZ[F]INDOL 2(4H) ONE; 7 METHOXY 6 PROPYLCARBAMOYLOXY 4A,5,6,7 TETRAHYDRO 1,3,4A,5 TETRAMETHYLBENZ[F]INDOL 2(4H) ONE; ANTIGESTAGEN; CP 8661; CP 8668; CP 8816; FURANONE DERIVATIVE; INDOLE DERIVATIVE; LG 100128; LG 120746; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; NORETHISTERONE; PF 1092A; PF 1092B; PF 1092C; PROGESTERONE; PROGESTERONE RECEPTOR; RWJ 26819; TANAPROGET; TETRAHYDROBENZINDOLONE DERIVATIVE; TETRAHYDRONAPTHOFURANONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CELL LINE; DRUG EVALUATION, PRECLINICAL; FURANS; HORMONE ANTAGONISTS; HUMANS; INDOLES; KINETICS; LIGANDS; NAPHTHOLS; RECEPTORS, PROGESTERONE; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 33646759877     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.03.022     Document Type: Article

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