Clinical relevance of circulating tumour cells in the bone marrow of patients with SCCHN

Onkologie

Volumn 27, Issue 4, 2004, Pages 358-362

  Wollenberg, B ^a,c   Walz, A ^a   Kolbow, K ^a   Pauli, C ^b   Chaubal, S ^b   Andratschke, M ^b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Micrometastases; Minimal residual disease; Occult tumour cells; SCCHN; Tumour marker

Indexed keywords

ANTIBODY; CYTOKERATIN 19;

ANALYTIC METHOD; ARTICLE; BONE MARROW BIOPSY; BONE MARROW CANCER; CANCER LOCALIZATION; CANCER PATIENT; CIRCULATION; CLINICAL PROTOCOL; CONTROLLED STUDY; CORRELATION ANALYSIS; FOLLOW UP; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MULTIVARIATE ANALYSIS; PREOPERATIVE PERIOD; PROGNOSIS; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STAINING; STATISTICAL SIGNIFICANCE; TUMOR CELL;

BIOPSY, NEEDLE; BONE MARROW; CARCINOMA, SQUAMOUS CELL; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINS; LYMPHATIC METASTASIS; NEOPLASM CIRCULATING CELLS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; NEOPLASM, RESIDUAL; OTORHINOLARYNGOLOGIC NEOPLASMS; PROGNOSIS; STATISTICS; TUMOR MARKERS, BIOLOGICAL;

EID: 4644333853     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079088     Document Type: Article

References (29)

1. Zbaren P, Lehmann W: Frequency and sites of distant metastases in head and neck squamous cell carcinoma. An analysis of 101 cases at autopsy. Arch Otolaryngol Head Neck Surg 1987;113:762-764.
2. Slootweg PJ, Bolle CW, Koole R, Hordijk GJ : Cause of death in squamous cell carcinoma of the head and neck. An autopsy study on 31 patients. J Craniomaxillofac Surg 1992;20:225-227.
3. Mayer B, Funke I, Johnson JP: High expression of a Lewis(x)-related epitope in gastric carcinomas indicates metastatic potential and poor prognosis. Gastroenterology 1996;111:1433-1446.
4. Burchill SA, Bradbury MF, Pittman K, Southgate J, Smith B, Selby P: Detection of epithelial cancer cells in peripheral blood by reverse transcriptasepolymerase chain reaction. Br J Cancer 1995;71:278-281.
5. Hermanek P, Scheibe O, Spiessl B, Wagner G: TNM classification of malignant tumors: The new 1987 edition. Röntgenbl 1987;40:200.
6. Loos JA, Roos D: Ficoll-isopaque gradients for the determination of density distributions of human blood lymphocytes and other reticulo-endothelial cells. Exp Cell Res 1974;86:333-341.
7. Cordell JL, Falini B, Erber WN, Ghosh AK, Abdulaziz Z, MacDonald S, Pulford KA, Stein H, Mason DY: Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984;32:219-229.
8. Cox DR: Regression models and life tables. J Stat Soc (B) 1972;34:187-220.
9. Kaplan EL, Meier P: Nonparametric estimation from incomplete observation. J Am Stat Assoc 1958;53:457-481.
10. Mansi JL, Easton D, Berger U, Gazet JC, Ford HT, Dearnaley D, Coombes RC: Bone marrow micrometastases in primary breast cancer: Prognostic significance after 6 years' follow-up. Eur J Cancer 1991;27:1552-1555.
11. Cote RJ, Rosen PP, Lesser ML, Old LJ, Osborne MP: Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases. J Clin Oncol 1991;9:1749-1756.
12. Lindemann F, Schlimok G, Dirschedl P, Witte J, Riethmuller G: Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients. Lancet 1992;340:685-689.
13. Riesenberg R, Oberneder R, Kriegmair M, Epp M, Bitzer U, Hofstetter A, Braun S, Riethmuller G, Pantel K: Immunocytochemical double staining of cytokeratin and prostate specific antigen in individual prostatic tumour cells. Histochemistry 1993;99:61-66.
14. Deguchi T, Doi T, Ehara H, Ito S, Takahashi Y, Nishino Y, Fujihiro S, Kawamura T, Komeda H, Horie M: Detection of micrometastatic prostate cancer cells in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res 1993;53:5350-5354.
15. Moul JW, Lewis DJ, Ross AA, Kahn DG, Ho CK, McLeod DG: Immunohistologic detection of prostate cancer pelvic lymph node micrometastases: Correlation to preoperative serum prostatespecific antigen. Urology 1994;43:68-73.
16. Pelkey TJ, Frierson HF Jr., Bruns DE: Molecular and immunological detection of circulating tumor cells and micrometastases from solid tumors. Clin Chem 1996;42:1369-1381.
17. Werner JA, Dunne AA, Myers JN: Functional anatomy of the lymphatic drainage system of the upper aerodigestive tract and its role in metastases of squamous cell carcinoma. Head Neck 2003;25:322-332.
18. Ervin TJ, Clark JR, Weichselbaum RR, Fallon BG, Miller D, Fabian RL, Posner MR, Norris CM Jr., Tuttle SA, Schoenfeld DA: An analysis of induction and adjuvant chemotherapy in the multidisciplinary treatment of squamous-cell carcinoma of the head and neck. J Clin Oncol 1987;5:10-20.
19. Vokes EE, Weichselbaum RR, Lippman SM, Hong WK: Head and neck cancer. N Engl J Med 1993;328:184-194.
20. Schlimok G, Funke I, Pantel K, Strobel F, Lindemann F, Witte J, Riethmuller G: Micrometastatic tumour cells in bone marrow of patients with gastric cancer: Methodological aspects of detection and prognostic significance. Eur J Cancer 1991;27:1461-1465.
21. Wollenberg B, Ollesch A, Maag K, Funke I, Wilmes E: Micrometastases in bone marrow of patients with cancers in the head and neck area. Laryngorhinootologie 1994;73:88-93.
22. Gath HJ, Heissler E, Hell B, Bier J, Riethmuller G, Pantel K: Immunocytologic detection of isolated tumor cells in bone marrow of patients with squamous cell carcinomas of the head and neck region. Int J Oral Maxillofac Surg 1995;24:351-355.
23. Gath HJ, Brakenhoff RH: Minimal residual disease in head and neck cancer. Cancer Metastases Rev 1999;18:109-126.
24. Pantel K, Schlimok G, Angstwurm M, Weckermann D, Schmaus W, Gath H, Passlick B, Izbicki JR, Riethmuller G: Methodological analysis of immunocytochemical screening for disseminated epithelial tumor cells in bone marrow. J Hematother 1994;3:165-173.
25. Partridge M, Brakenhoff R, Philips E, Ali K, Francis R, Hooper R, Lavery K, Brown A, Langdon: Detection of rare disseminated tumor cells identifies head and neck cancer patients at risk of treatment failure. J Clin Cancer Res 2003;9:5287-5294.
26. De Graaf H, Maelandsmo GM, Ruud P, Forus A, Oyjord T, Fodstad O, Hovig E: Ectopic expression of target genes may represent an inherent limitation of RT-PCR assays used for micrometastases detection: Studies on the epithelial glycoprotein gene EGP-2. Int J Cancer 1997;72:191-196.
27. Zippelius A, Pantel K: RT-PCR-based detection of occult disseminated tumor cells in peripheral blood and bone marrow of patients with solid tumors. An overview. Ann N Y Acad Sci 2000;906:110-123.
28. Chaubal S, Wollenberg B, Kastenbauer E, Zeidler R: Ep-CAM-a marker for the detection of disseminated tumor cells in patients suffering from SCCHN. Anticancer Res 1999;19(3B):2237-2242.
29. Andratschke M, Pauli C, Stein M, Chaubal S, Wollenberg B: MHC-class I antigen expression on micrometastases in bone marrow of patients with head and neck squamous cell cancer. Anticancer Res 2003;23(2B):1467-1471.