Liver hepcidin and stainable iron expression in biliary atresia

Pediatric Research

Volumn 59, Issue 5, 2006, Pages 662-666

  Huang, Ying Hsien ^a,d   Yu Hsieh, Hui ^b   Huang, Chao Cheng ^d   Shin Mu, Vincent Tseng ^b   Tai, Ming Hong ^c   Chen, Chao Long ^a   Chuang, Jiin Haur ^a,d  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^d CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; IRON; MESSENGER RNA;

ADOLESCENT; ADULT; ANEMIA; ANTIMICROBIAL ACTIVITY; ARTICLE; BILE DUCT ATRESIA; CHILD; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HOMEOSTASIS; HUMAN; IMMUNOHISTOCHEMISTRY; IRON METABOLISM; IRON TRANSPORT; KUPFFER CELL; LIVER RESECTION; LIVER TRANSPLANTATION; MALE; PORTOENTEROSTOMY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANTIMICROBIAL CATIONIC PEPTIDES; BASE SEQUENCE; BILIARY ATRESIA; CASE-CONTROL STUDIES; CHILD, PRESCHOOL; DNA, COMPLEMENTARY; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; IRON; LIVER; MALE; RNA, MESSENGER;

EID: 33646708288     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.pdr.0000214974.55049.f1     Document Type: Article

References (31)

1. Fischler B, Ehrnst A, Forsgren M, Orvell C, Nemeth A 1998 The viral association of neonatal cholestasis in Sweden: a possible link between cyto megalovirus infection and extrahepatic biliary atresia. J Pediatr Gastroenterol Nutr 27:57-64
2. Drut R, Drut RM, Gomez MA, Cueto Rua E, Lojo MM 1998 Presence of human papillomavirus in extrahepatic biliary atresia. J Pediatr Gastroenterol Nutr 27:530-535
3. Bobo L, Ojeh C, Chiu D, Machado A, Colombani P, Schwarz K 1997 Lack of evidence for rotavirus by polymerase chain reaction/enzyme irnmunoassay of hepatobiliary samples from children with biliary atresia. Pediatr Res 41:229-234
4. Mason AL, Xu L, Guo L, Munoz S, Jaspan JB, Bryer-Ash M, Cao Y, Sander DM, Shoenfeld Y, Ahmed A, Van de Water J, Gershwin ME, Garry RF 1998 Detection of retro viral antibodies in primary biliary cirrhosis and other idiopathic biliary disorders. Lancet 351:1620-1624
5. Redkar R, Davenport M, Howard ER 1998 Antenatal diagnosis of congenital anomalies of the biliary tract. J Pediatr Surg 33:700-704
6. Tanano H, Hasegawa T, Kawahara H, Sasaki T, Okada A 1999 Biliary atresia associated with congenital structural anomalies. J Pediatr Surg 34:1687-1690
7. Carmi R, Magee CA, Neill CA, Karrer FM 1993 Extrahepatic biliary atresia and associated anomalies: etiologic heterogeneity suggested by distinctive patterns of associations. Am J Med Genet 45:683-693
8. Ando K, Miyano T, Fujimoto T, Ohya T, Lane G, Tawa T, Tokita A, Yabuta K 1996 Sibling occurrence of biliary atresia and biliary dilatation. J Pediatr Surg 31:1302-1304
9. Czech-Schmidt G, Verhagen W, Szavay P, Leonhardt J, Petersen C 2001 Immunological gap in the infectious animal model for biliary atresia. J Surg Res 101:62-67
10. Chen CL, Chen YS, de Villa VH, Wang CC, Lin CL, Goto S, Wang SH, Cheng YF, Huang TL, Jawan B, Cheung HK 2000 Minimal blood loss living donor hepatectomy. Transplantation 69:2580-2586
11. Jain A, Reyes J, Kashyap R, Dodson SF, Demetris AJ, Ruppert K, Abu-Elmagd K, Marsh W, Madariaga J, Mazariegos G, Geller D, Bonham CA, Gayowski T, Cacciarelli T, Fontes P, Starzl TE, Fung JJ 2000 Long-term survival after liver transplantation in 4,000 consecutive patients at a single center. Ann Surg 232:490-500
12. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K 2000 LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480:147-150
13. Andrews NC 2004 Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 113:1251-1253
14. Ganz T 2003 Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102:783-788
15. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T 2004 IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113:1271-1276
16. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O 2001 A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276:7811-7819
17. Tazawa Y, Abukawa D, Maisawa S, Nishinomiya F, Oyake Y, Takada G, Konno T 1998 Idiopathic neonatal hepatitis presenting as neonatal hepatic siderosis and steatosis. Dig Dis Sci 43:392-396
18. Ben-Dor A, Bruhn L, Friedman N, Nachman I, Schummer M, Yakhini Z 2000 Tissue classification with gene expression profiles. J Comput Biol 7:559-583
19. Zuo F, Kaminski N, Eugui E, Allard J, Yakhini Z, Ben-Dor A, Lollini L, Morris D, Kim Y, DeLustro B, Sheppard D, Pardo A, Selman M, Heller RA 2002 Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci USA 99:6292-6297
20. Gibson UE, Heid CA, Williams PM 1996 A novel method for real time quantitative RT-PCR. Genome Res 6:995-1001
21. Li AC, Brown KK, Silvestre MJ, Willson TM, Palinski W, Glass CK 2000 Peroxisome proliferator-activated receptor gamma ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J Clin Invest 106:523-531
22. Barton JC, Edwards CQ, Bertoli LF, Shroyer TW, Hudson SL 1995 Iron overload in African Americans. Am J Med 99:616-623
23. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W 2004 Pro-hepcidin: expression and cell specific localisation in the river and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia Gut 53:735-743
24. Aoki CA, Rossaro L, Ramsamooj R, Brandhagen D, Burritt MF, Bowlus CL 2005 Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J Clin Gastroenterol 39:71-74
25. Park CH, Valore EV, Waring AJ, Ganz T 2001 Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-7810
26. Wu ET, Chen HL, Ni YH, Lee PI, Hsu HY, Lai HS, Chang MH 2001 Bacterial cholangitis in patients with biliary atresia: impact on short-term outcome. Pediatr Surg Int 17:390-395
27. Lunzmann K, Schweizer P 1999 The influence of cholangitis on the prognosis of extrahepatic biliary atresia. Eur J Pediatr Surg 9:19-23
28. Jiang CB, Lee HC, Yeung CY, Sheu JC, Chang PY, Wang NL, Yeh CY 2003 A scoring system to predict the need for liver transplantation for biliary atresia after Kasai portoenterostomy. Eur J Pediatr 162:603-606
29. Faa G, Sciot R, Farci AM, Callea F, Ambu R, Congiu T, van Eyken P, Cappai G, Marras A, Costa V 1994 Iron concentration and distribution in the newborn liver. Liver 14:193-199
30. Knisely AS 1992 Neonatal hemochromatosis. Adv Pediatr 39:383-403
31. Ng PC, Lam CW, Lee CH, To KF, Fok TF, Chan IH, Wong E 2001 Hepatic iron storage in very low birthweight infants after multiple blood transfusions. Arch Dis Child Fetal Neonatal Ed 84:F101-F105