Absorption enhancement study of astragaloside IV based on its transport mechanism in Caco-2 cells

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 31, Issue 1, 2006, Pages 5-10

  Huang, C R ^a   Wang, G J ^a   Wu, X L ^a   Li, H ^a   Xie, H T ^a   Lv, H ^a   Sun, J G ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Absorption enhancement; Astragaloside IV; Caco 2 cells; Intestinal transport

Indexed keywords

ASTRAGALOSIDE 4; CALCIUM ION; CHITOSAN; DEOXYCHOLATE SODIUM; EDETIC ACID; SAPONIN; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG PENETRATION; DRUG STRUCTURE; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; PASSIVE TRANSPORT;

EID: 33646701387     PISSN: 03787966     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03190635     Document Type: Article

References (20)

1. Hikino, H., Funayama, S., Endo, K. (1976): Hypotensive principle of Astragalus and Hedysarum roots. Planta Med. 30, 297.
2. Zhang, W.J., Hufnagl, P., Binder, B.R., et al (2003): Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thromb Haemost 90, 904-914.
3. Bedir, E., Pugh, N., Calis, I., et al (2000): Immunostimulatory effects of cycloartane-type triterpene glycosides from Astragalus species. Biol. Pharm. Bull 23, 834.
4. Li, Z.P., Cao, Q. (2002): Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats. Acta Pharmacol. Sin. 23, 898-904.
5. Yang, Q., Lu, J.T., Zhou, A.W., et al (2001): Antinociceptive effect of astragalosides and its mechanism of action. Acta Pharmacol. Sin. 22, 809-12.
6. Zhang, Y.D., Shen, J.P., Zhu, S.H., et al (1992): Effects of astragalus (ASI, SK) on experimental liver injury. Yao Xue Xue Bao, 27, 401-406.
7. 2-· and ·OH, Zhong Yao Cai 22, 303-306.
8. Luo, Y., Qin, Z., Hong, Z. (2004): Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neuro. Let. 363, 218-223.
9. Gu, Y., Wang, G., Pan, G.Y. (2004): Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix astragali. Basic Clin. Pharmacol. Toxicol. 95, 295-298.
10. Gan, L.S.L., Thakker, D.R. (1997): Applications of the Caco-2 model in the design and development of orally active drugs elucidation of biochemical and physical barriers posed by the intestinal epithelium. Adv. Drug Deliv. Rev. 23, 77-98.
11. Artursson, P., Karlsson, J. (1991): Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175, 880-885.
12. Artursson, P., Magnusson, C. (1990): Epithelial transport of drugs in cell culture. II. Effect of extracellular calcium concentration on the paracellular transport of drugs of different lipophilicities across monolayers of the intestinal epithelial (Caco-2) cells. J. Pharm. Sci 79, 595-600.
13. De Boer, A., Noach, A., Roosemalen, M., et al (1991): Effect of apical and/or basolateral application of EDTA on the permeability of hydrophilic compounds in a human intestinal epithelial cell line (Caco-2). Pharm. Res. 8, S215.
14. Artursson, P. (1991): Cell cultures as models for drug absoption across the intestinal mucosa. Crit. Rev. Ther. Drug Carrier Syst. 8, 305-330.
15. Artursson, P., Lindmark, T., Davis, S.S. et al (1994): Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm. Res. 11, 1358-1361.
16. Illum, L., Farraj, N.F., Davis, S.S. (1994): Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. 11, 1186-1189.
17. Schipper, N.G., Varum, K.M., Artursson, P. (1996): Chitosan as absorption enhancers for poorly absorbable drugs. 1. Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm. Res. 13, 1686-1692.
18. Shin, S.C., Bum, J.P., Choi, J.S. (2000): Enhanced bioavailability by buccal administration of triamcinolone acetonide from the bioadhesive gels in rabbits. Int. J. Pharm. 209, 37-43.
19. Uchiyama, T., Sugiyama, T., Quan, Y.S., et al (1999): Enhanced permeability of insulin across the rat intestinal membrane by various absorption enhancers: their intestinal mucosal toxicity and absorption-enhancing mechanism of n-lauryl-beta-D-maltopyranoside. Pharm. Pharmacol. 51, 1241-1250.
20. Sakai, M., Imai, T., Ohtake, H., et al (1999): Simultaneous use of sodium deoxycholate and dipotassium glycyrrhizinate enhances the cellular transport of poorly absorbed compounds across Caco-2 cell monolayers. J. Pharm. Pharmacol. 51, 27-33.