Anticholinergic effects on acquisition of place learning in the Morris water task: Spatial mapping deficit or inability to inhibit nonplace strategies?

Behavioral Neuroscience

Volumn 110, Issue 5, 1996, Pages 998-1005

  Day, Lainy Baird ^a   Schallert, Timothy ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN MAPPING; CHOLINERGIC NERVE; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; LEARNING; MALE; NONHUMAN; RAT; SPATIAL ORIENTATION; SWIMMING; TASK PERFORMANCE;

ANIMALS; ATROPINE; BRAIN; CHOLINERGIC ANTAGONISTS; CUES; ESCAPE REACTION; MALE; MAZE LEARNING; MENTAL RECALL; NEURAL INHIBITION; ORIENTATION; PROBLEM SOLVING; RATS; REACTION TIME; RECEPTORS, CHOLINERGIC;

EID: 0029858444     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.110.5.998     Document Type: Article

References (31)

1. Amsel, A. (1993). Hippocampal function in the rat: Cognitive mapping or vicarious trial and error? Hippocampus, 3, 251-256.
2. Baxter, M. B., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (1995). Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats. Behavioral Neuroscience, 109, 714-722.
3. Berger-Sweeney, J., Heckers, S. L., Mesulam, M. M., Wiley, R. G., Lappi, D. A., & Sharma, M. (1994). Differential effects on spatial navigation of immunotoxin-induced cholinergic lesions of the medial septal area and nucleus basalis magnocellularis. Journal of Neuroscience, 14, 4507-4519.
4. Blodgett, H. C., McCutchan, K., & Mathews, R. (1949). Spatial learning in the T maze: The influence of direction, turn, and food location. Journal of Experimental Psychology, 39, 800-809.
5. Bramlett, H. M., Green, E. J., Dietrich, W. D., Busto, R., Globus, M. Y.-T., & Ginsberg, M. D. (1995). Post-traumatic brain hypothermia provides protection from sensorimotor and cognitive behavioral deficits. Journal of Neurotrauma, 12, 289-298.
6. DeVietti, T. L., Pellis, S. M., Pellis, V. C., & Teitelbaum, P. (1985). Previous experience disrupts atropine-induced stereotyped "trapping" in rats. Behavioral Neuroscience, 99, 1128-1141.
7. DiMattia, B. D., & Kesner, R. P. (1988). Spatial cognitive maps: Differential role of parietal cortex and hippocampal formation. Behavioral Neuroscience, 102, 471-480.
8. Douglas, R. J. (1967). The hippocampus and behavior. Psychological Bulletin, 67, 416-442.
9. Gabriel, M., Sparenborg, S. P., & Stolar, N. (1987). Hippocampal control of cingulate cortical and anterior thalamic information processing during learning in rabbits. Experimental Brain Research, 67, 131-152.
10. Gage, F. H., Dunnett, S. B., & Bjorklund, A. (1984). Spatial learning and motor deficits in aged rats. Neurobiology of Aging, 5, 43-48.
11. Gallagher, M., Burwell, R., & Burchinal, M. (1993). Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze. Behavioral Neuroscience, 107, 618-626.
12. Gray, J. A., & McNaughton, N. (1983). Comparison between the behavioral effects of septal and hippocampal lesions: A review. Neuroscience and Biobehavioral Reviews, 7, 119-188.
13. Green, E. J., Dietrich, W. D., Van Dijk, F., Busto, R., Markgraf, C. G., McCabe, P. M., Ginsberg, M. D., & Schneiderman, N. (1992). Protective effects of brain hypothermia on behavior and histopathology following global cerebral ischemia in rats. Brain Research, 580, 197-204.
14. Hamm, R. J., Dixon, C. E., Gbadebo, D. M., Singha, A. K., Jenkins, L. W., Lyeth, B. G., & Hayes, R. L. (1992). Cognitive deficits following traumatic brain injury produced by controlled cortical impact. Journal of Neurotrauma, 9, 11-20.
15. Hamm, R. J., Lyeth, B. G., Jenkins, L. W., O'Dell, D. M., & Pike, B. (1993). Selective cognitive impairment following traumatic brain injury in rats. Behavioral Brain Research, 59, 169-173.
16. Kimble, D. P. (1968). Hippocampus and internal inhibition. Psychology Bulletin, 70, 285-295.
17. Kolb, B., Sutherland, R. J., & Whishaw, I. Q. (1983). A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats. Behavioral Neuroscience, 97, 12-27.
18. Lindner, M. D., & Schallert, T. (1988). Aging and atropine effects on spatial navigation in the Morris water task. Behavioral Neuroscience, 102, 621-634.
19. Morris, R. G. M. (1981). Spatial localization does not require the presence of local cues. Learning and Motivation, 12, 239-261.
20. Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982). Place navigation impaired in rats with hippocampal lesions. Nature, 297, 681-683.
21. Nilsson, P., Hillered, L., Ponten, U., & Ungerstedt, U. (1990). Changes in cortical extracellular levels of energy-related metabolites and amino acids following concussive brain injury in rats. Journal of Cerebral Blood Flow and Metabolism, 10, 631-637.
22. Nilsson, O. G., Leanza, G., Rosenblad, C., Lappi, D. A., Wiley, R. G., & Bjorklund, A. (1992). Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system. NeuroReport, 3, 1005-1008.
23. O'Keefe, J., & Nadel, L. (1978). The hippocampus as a cognitive map. Oxford, England: Clarendon Press.
24. Rapp, P. R., Rosenberg, R. A., & Gallagher, M. (1987). An evaluation of spatial information processing in aged rats. Behavioral Neuroscience, 101, 3-12.
25. Saucier, D., Hargreaves, E. L., Boon, F., Vanderwolf, C. H., & Cain, D. P. (1996). Detailed behavioral analysis of water maze acquisition under systemic and NMDA or muscarinic antagonism: Non-spatial pretraining eliminates spatial learning deficits. Behavioral Neuroscience, 110, 103-116.
26. Schallert, T., De Ryck, M., & Teitelbaum, P. (1980). Atropine stereotypy as a behavioral trap: A movement subsystem and electroencephalographic analysis. Journal of Comparative and Physiological Psychology, 94, 1-23.
27. Sutherland, R. J., Whishaw, I. Q., & Kolb, B. (1982). Spatial mapping: Definitive disruption by hippocampal or medial frontal damage in the rat. Neuroscience Letters, 31, 271-276.
28. Sutherland, R. J., Whishaw, I. Q., & Regehr, J. C. (1982). Cholinergic receptor blockade impairs spatial localization by use of distal cues in the rat. Journal of Comparative and Physiological Psychology, 96, 563-573.
29. Whishaw, I. Q. (1985). Cholinergic receptor blockade in the rat impairs locale but not taxon strategies for place navigation in a swimming pool. Behavioral Neuroscience, 99, 979-1005.
30. Whishaw, I. Q. (1995). Rats with fimbria-fornix lesions display a place response in a swimming pool: A dissociation between getting there and knowing where. Journal of Neuroscience, 15, 5779-5788.
31. Yamamura, H. I., Kuhar, M. J., & Snyder, S. H. (1974). In vivo identification of muscarinic Cholinergic receptor binding in rat brain. Brain Research, 80, 170-176.