Piperidines: A new class of Urease inhibitors

Natural Product Research

Volumn 20, Issue 6, 2006, Pages 523-530

  Khan, Khalid Mohammed ^a   Saify, Zafar S ^a   Lodhi, Muhammad Arif ^a   Butt, Naeem ^b   Perveen, Shahnaz ^a   Maharvi, Ghulam Murtaza ^a   Choudhary, Muhammad Iqbal ^a   Atta Ur Rahman, ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

^b PCSIR LABORATORIES COMPLEX   (Pakistan)

Author keywords

1,4 bipiperidine; 4 (aminomethyl)piperidine; Piperidines; Urease

Indexed keywords

1 ACETYL 1,4 BIPIPERIDINE; 1 MYRITOYL 1,4 BIPIPERIDINE; 1 NICOTINOYL 1,4 BIPIPERIDINE; 2 NAPTHOYL 1,4 BIPIPERIDINE; 2,2,2 TRIFLUORO N [[1 (2,2,2 TRIFLUOROACETYL) 4 PIPERIDINYL]METHYL]ACETAMIDE; 3' PHENOXYPROPYL 1,4 BIPIPERIDINE; 3',4',5' TRIMETHOXY N [1 (3,4,5 TRIMETHOXYBENZOYL) 4 PIPERIDINYL]METHYL]BENZAMIDE; 3',4',5' TRIMETHOXYBENZOYL 1,4 BIPIPERIDINE; 4 METHYL N [[1 (4 METHYLBENZOYL) 4 PIPERIDINYL]METHYL]BENZAMIDE; 4 METHYL N [[1 [(4 METHYLPHENYL)SULFONYL] 4 PIPERIDINYL]METHYL]BENZENESULFONAMIDE; 4 NITRO N [[1 (4 NITROPHENYL)SULFONYL] 4 PIPERIDINYL]METHYL]ENZENESULFONAMIDE; 4' METHYLBENOZYL 1,4 BIPIPERIDINE; 4' METHYLBENZYL 1,4 BIPIPERIDINE; 4' NITROBENZENSULFONYL 1,4 BIPIPERIDINE; METHYL 1,4 BIPIPERIDINE 3' PROPANOIC ACID; METHYL [4 [[(3 METHOXY 3 OXOPROPYL)AMINO]METHYL] 1 PIPERIDINYL]PROPANOIC ACID; N (3 METHYL 2 BUTENYL) N [[1 (3 METHYL 3 BUTENYL) 4 PIPERIDINYL]METHYL]AMINE; N (3 PHENOXYPROPYL) N [[1 (3 PHENOXYPROPYL) 4 PIPERIDINYL]METHYL]AMINE; N (4 METHYLBENZYL) N [[1 (4 METHYLBENZYL) 4 PIPERIDINYL]METHYL]AMINE; N [(1 ACETYL 4 PIPERIDINYL)METHYL]ACETAMIDE; N [(1 TETRADECANOYL 4 PIPERIDINYL)METHYL]TETRADECANAMIDE; N [[1 (3 PYRIDINYLCARBONYL) 4 PIPERIDINYL]METHYL]NICOTINAMIDE; N [[1 (MESITYLSULFONYL) 4 PIPERIDINYL]METHYL] 2,4,6 TRIMETHYLBENZENESULFONAMIDE; PIPERIDINE DERIVATIVE; TRIFLUOROACETYL 1,4 BIPIPERIDINE; UNCLASSIFIED DRUG; UREASE INHIBITOR;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PIPERIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; UREASE;

TRIFLUORO;

EID: 33646691984     PISSN: 14786419     EISSN: 14786427     Source Type: Journal    
DOI: 10.1080/1478641500059383     Document Type: Article

References (20)

1. Mobley, HLT and Hausinger, RP. (1989) Microbiol. Rev., 53, pp. 85.
2. Zonia, LE and Stebbins, NE and Polacco, JC. (1995) Plant Physiol., 107, pp. 1097.
3. Mulvaney, RL and Bremner, JM. (1981) Soil Biochemistry. E.A. Paul, J.N. Ladd (Eds), pp. 153-196, Marcel Dekker, Inc., New York
4. Mobley, HLT and Island, MD and Hausinger, RP. (1995) Microbiol. Rev., 59, pp. 451.
5. Bayerdorffer, E and Ottenjhan, R. (1988) Scand. J. Gastroenterol., 23, pp. 93.
6. Mesaik, MA and Rahat, S and Khan, KM and Choudhary, MI and Shahnaz, M and Ismaeil, Z and Atta-ur-Rahman and Ahmad, A and Zia-Ullah. (2004) Bioorg. Med. Chem., 12, pp. 2049-2057.
7. Chohan, ZH and Pervez, H and Khan, KM and Rauf, A and Maharvi, GM and Supuran, CT. (2004) J. Enz. Inhib. Med. Chem., 19, pp. 85-90.
8. Khan, KM and Saify, ZS and Khan, MZ and Hayat, S and Begum, S and Noor, F and Choudhary, MI and Perveen, S. (2004) Atta-ur-Rahman, Nat. Prod. Res, 18, pp. 21-27.
9. Imtiaz-ud-Din and Mazhar, M and Khan, KM and Mahon, MF and Molloy, KC. (2004) J. Organomet. Chem., 689, pp. 899-908.
10. Hussain, M and Hussain, MT and Rama, NH and Hameed, S and Malik, A and Khan, KM. (2003) Nat. Prod. Res., 17, pp. 207-214.
11. Khan, KM and Rasheed Zia-Ullah, M and Hayat, S and Kaukab, F and Choudhary, MI and Atta-ur-Rahman. (2003) Bioorg. Med. Chem., 11, pp. 1381-1387.
12. Khan, KM and Saify, ZS and Begum, S and Noor, F and Khan, MZ and Hayat, S and Choudhary, MI and Perveen Zia-Ullah, S. (2003) Nat. Prod. Res., 17, pp. 115-125.
13. Mahmood, S and Ali, S and Bhatti, MH and Mazhar, M and Iqbal, R and Khan, KM and Maharvi, GM. (2003) Turk. J. Chem., 27, pp. 657-666.
14. Khan, KM and Rahat, S and Choudhary, MI and Atta-ur-Rahman and Ghani, U and Perveen, S and Khatoon, S and Dar Abdul Malik, A. (2002) Helv. Chem. Acta, 85, pp. 559-570.
15. Khan, KM and Saify, ZS and Shah, STA and Khan, A and Ahmed, M and Saeed, M and Hayat, S and Abbas, M and Voelter, W. (2002) Arzneim-Forsch./Drug Res., 52, pp. 286-293.
16. Khan, KM and Shujaat, S and Rahat, S and Hayat, S and Atta-ur-Rahman and Choudhary, MI. (2002) Chem. Pharm. Bull. Japan, 50, pp. 1443-1446.
17. Amtul, Z and Rasheed, M and Choudhary, MI and Rosanna, S and Khan, KM and Atta-ur-Rahman. (2004) Biochem. Biophys. Res. Commun., 319, pp. 1053-1063.
18. Khan, KM and Iqbal, S and Lodhi, MA and Maharvi, GM and Zia-Ullah and Choudhary, MI and Atta-ur-Rahman and Parveen, S. (2004) Bioorg. Med. Chem., 12, pp. 1963-1968.
19. Khan, KM and Iqbal, S and Lodhi, MA and Maharvi, GM and Choudhary, MI and Atta-ur-Rahman and Chohan, ZH and Supuran, CT. (2004) J. Enz. Inhib. Med. Chem. (in press)
20. Weatherburn, MW. (1967) Anal. Chem., 39, pp. 971.