Testosterone therapy for postmenopausal women: Efficacy and safety

Seminars in Reproductive Medicine

Volumn 24, Issue 2, 2006, Pages 115-123

  Somboonporn, Woraluk ^a  

^a KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Hormone therapy; Postmenopausal women; Testosterone

Indexed keywords

ESTRATEST; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METHYLTESTOSTERONE; TESTOSTERONE; TESTOSTERONE ESTER; TESTOSTERONE UNDECANOATE; TRIACYLGLYCEROL;

ACNE; AGGRESSION; ANDROGEN DEFICIENCY; ATHEROSCLEROSIS; BODY COMPOSITION; BREAST CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COGNITION; CORONARY ARTERY DISEASE; DRUG EFFICACY; DRUG MONITORING; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; HIRSUTISM; HORMONAL THERAPY; HUMAN; HYPERANDROGENISM; MENOPAUSAL SYNDROME; MOOD DISORDER; POSTMENOPAUSE; REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; SEXUAL FUNCTION; SIDE EFFECT; TESTOSTERONE THERAPY; WELLBEING;

ANDROGENS; BODY COMPOSITION; BONE AND BONES; BREAST NEOPLASMS; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; COGNITION; ESTROGEN REPLACEMENT THERAPY; FATIGUE; FEMALE; HUMANS; LIBIDO; POSTMENOPAUSE; RISK FACTORS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; TESTOSTERONE;

EID: 33646679639     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-939570     Document Type: Review

References (72)

1. Davis S. Androgen replacement in women: a commentary. J Clin Endocrinol Metab 1999;84:1886-1891
2. Simpson ER. Role of aromatase in sex steroid action. J Mol Endocrinol 2000;25:149-156
3. Bachmann G, Bancroft J, Braunstein G, et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 2002;77:660-665
4. Heinonen PK, Koivula T, Rajaniemi H, Pystynen P. Peripheral and ovarian venous concentrations of steroid and gonadotropin hormones in postmenopausal women with epithelial ovarian tumors. Gynecol Oncol 1986;25:1-10
5. Laughlin GA, Barrett-Connor E, Kritz-Silverstein D, von Muhlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo Study. J Clin Endocrinol Metab 2000;85:645-651
6. Hughes CL Jr, Wall LL, Creasman WT. Reproductive hormone levels in gynecologic oncology patients undergoing surgical castration after spontaneous menopause. Gynecol Oncol 1991;40:42-45
7. Judd HL, Lucas WE, Yen SS. Effect of oophorectomy on circulating testosterone and androstenedione levels in patients with endometrial cancer. Am J Obstet Gynecol 1974;118:793-798
8. Bancroft J, Cawood EH. Androgens and the menopause; a study of 40-60-year-old women. Clin Endocrinol (Oxf) 1996;45:577-587
9. Burger HG, Dudley EC, Hopper JL, et al. The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample. J Clin Endocrinol Metab 1995;80:3537-3545
10. Overlie I, Moen MH, Morkrid L, Skjaeraasen JS, Holte A. The endocrine transition around menopause-a five years prospective study with profiles of gonadotropines, estrogens, androgens and SHBG among healthy women. Acta Obstet Gynecol Scand 1999;78:642-647
11. Rannevik G, Jeppsson S, Johnell O, et al. A longitudinal study of the perimenopausal transition: altered profiles of steroid and pituitary hormones, SHBG and bone mineral density. Maturitas 1995;21:103-113
12. Rozenberg S, Bosson D, Peretz A, Caufriez A, Robyn C. Serum levels of gonadotrophins and steroid hormones in the post-menopause and later life. Maturitas 1988;10:215-224
13. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL. A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 2000;85:2832-2838
14. Judd HL, Yen SS. Serum androstenedione and testosterone levels during the menstrual cycle. J Clin Endocrinol Metab 1973;36:475-481
15. Massafra C, De FC, Agnusdei DP, Gioia D, Bagnoli F. Androgens and osteocalcin during the menstrual cycle. J Clin Endocrinol Metab 1999;84:971-974
16. Mushayandebvu T, Castracane VD, Gimpel T, Adel T, Santoro N. Evidence for diminished midcycle ovarian androgen production in older reproductive aged women. Fertil Steril 1996;65:721-723
17. Hormone therapy for the prevention of chronic conditions in postmenopausal women: recommendations from the U.S. Preventive Services Task Force. Ann Intern Med 2005;142:855-860
18. Davis SR. Androgens and female sexuality. J Gend Specif Med 2000;3:36-40
19. Davis SR. Rationale for treating hypoandrogenism in women. In: Bagatell C, Bremner W, eds. Androgens in Health and Disease. Totowa, NJ: Humana Press; 2003:365-379
20. Lobo RA. Androgens in postmenopausal women: production, possible role, and replacement options. Obstet Gynecol Surv 2001;56:361-376
21. Wang C, Swerdloff R. Androgen pharmacology and delivery systems. In: Bagatell C, Bremner W, eds. Androgens in Health and Disease. Totowa, NJ: Humana Press; 2003:141-153
22. Simerly RB. Distribution and regulation of steroid hormone receptor gene expression in the central nervous system. Adv Neurol 1993;59:207-226
23. Celotti F, Negri-Cesi P, Poletti A. Steroid metabolism in the mammalian brain: 5alpha-reduction and aromatization. Brain Res Bull 1997;44:365-375
24. Macs M, Meltzer HY. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ, eds. Psychopharmacology. The Fourth Generation of Progress. New York: Raven Press; 1995:933-944
25. Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-688
26. Buster JE, Kingsberg SA, Aguirre O, et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 2005;105:944-952
27. Montgomery JC, Appleby L, Brincat M, et al. Effect of oestrogen and testosterone implants on psychological disorders in the climacteric. Lancet 1987;1:297-299
28. Sherwin BB, Gelfand MM. Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause. Am J Obstet Gynecol 1985;151:153-160
29. Floter A, Nathorst-Boos J, Carlstrom K, von Schoultz B. Addition of testosterone to estrogen replacement therapy in oophorectomized women: effects on sexuality and well-being. Climacteric 2002;5:357-365
30. Regestein QR, Friebely J, Shifren J, Schiff I. Neuropsychological effects of methyltestosterone in women using menopausal hormone replacement. J Womens Health Gend Based Med 2001;10:671-676
31. Bancroft J. Androgens and sexual function in men and women. In: Bagatell C, Bremner W, eds. Androgens in Health and Disease. Totowa, NJ: Humana Press; 2003:259-290
32. Cameron DR, Braunstein GD. Androgen replacement therapy in women. Fertil Steril 2004;82:273-289
33. Davis S, Davison S, Donath S, Bell R. Circulating androgen levels and self-reported sexual function in women. JAMA 2005;294:91-96
34. Braunstein G, Shifren J, Simon J, et al. Testosterone patches for the treatment of low sexual desire in surgically menopausal women. Paper presented at the NAMS 2003, 14th Annual Meeting; May 17-21, 2003; Jackson Hole, WY
35. Davis S, Lucas J, Moufarege A, Braunstein G. Testosterone patches for treatment of low sexual desire in surgically menopausal women. Paper presented at: 7th Australian Menopause Society Congress; November 13-15, 2003; Tasmania, Australia
36. Davis SR, McCloud P, Strauss BJ, Burger H. Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality. Maturitas 1995;21:227-236
37. Lobo RA, Rosen RC, Yang HM, Block B, Van Der Hoop RG. Comparative effects of oral esterified estrogens with and without methyltestosterone on endocrine profiles and dimensions of sexual function in postmenopausal women with hypoactive sexual desire. Fertil Steril 2003;79:1341-1352
38. Sarrel P, Dobay B, Wiita B. Estrogen and estrogen-androgen replacement in postmenopausal women dissatisfied with estrogen-only therapy. Sexual behavior and neuroendocrine responses. J Reprod Med 1998;43:847-856
39. Dobs AS, Nguyen T, Pace C, Roberts CP. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab 2002;87:1509-1516
40. Shepanek M. A study of estrogen androgen replacement therapy (EART) versus estrogen replacement therapy [dissertation]. Washington, DC: Georgetown University; 1999
41. Sherwin BB, Gelfand MM, Brender W. Androgen enhances sexual motivation in females: a prospective, crossover study of sex steroid administration in the surgical menopause. Psychosom Med 1985;47:339-351
42. Burger H, Hailes J, Nelson J, Menelaus M. Effect of combined implants of oestradiol and testosterone on libido in postmenopausal women. Br Med J (Clin Res Ed) 1987;294:936-937
43. Luciano A, Miller B, Sequenzia L, et al. The effect of sublingual micronized estradiol, progesterone and testosterone on menopausal symptoms and sexual health. Paper presented at: the 9th International Menopause Society World Congress on the Menopause; October 17-20, 1999; Yokohama, Japan
44. Penotti M, Sironi L, Cannata L, et al. Effects of androgen supplementation of hormone replacement therapy on the vascular reactivity of cerebral arteries. Fertil Steril 2001;76:235-240
45. Barrett-Connor E, Young R, Notelovitz M, et al. A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. J Reprod Med 1999;44:1012-1020
46. Dow MG, Hart DM, Forrest CA. Hormonal treatments of sexual unresponsiveness in postmenopausal women: a comparative study. Br J Obstet Gynaecol 1983;90:361-366
47. Somboonporn W, Davis S, Seif M, Bell R. Testosterone for peri- and postmenopausal women. The Cochrane Database of Systematic Reviews 2005; issue 4. Article No: CD004509
48. Kenny AM, Raisz LG. Androgens and bone. In: Bagatell C, Bremner W, eds. Androgens in Health and Disease. Totowa, NJ: Humana Press; 2003:221-232
49. Vanderschueren D, Vandenput L, Boonen S, et al. Androgens and bone. Endocr Rev 2004;25:389-425
50. Garnett T, Studd J, Watson N, Sawas M, Leather A. The effects of plasma estradiol levels on increases in vertebral and femoral bone density following therapy with estradiol and estradiol with testosterone implants. Obstet Gynecol 1992;79:968-972
51. Watts NB, Notelovitz M, Timmons MC, et al. Comparison of oral estrogens and estrogens plus androgen on bone mineral density, menopausal symptoms, and lipid-lipoprotein profiles in surgical menopause. Obstet Gynecol 1995;85:529-537
52. Miller J, Chan BK, Nelson HD. Postmenopausal estrogen replacement and risk for venous thromboembolism: a systematic review and meta-analysis for the U.S. Preventive Services Task Force. Ann Intern Med 2002;136:680-690
53. Raisz LG, Wiita B, Artis A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996;81:37-43
54. Davis SR, Walker KZ, Strauss BJ. Effects of estradiol with and without testosterone on body composition and relationships with lipids in postmenopausal women. Menopause 2000;7:395-401
55. Bates KA, Harvey AR, Carruthers M, Martins RN. Androgens, andropause and neurodegeneration: exploring the link between steroidogenesis, androgens and Alzheimer's disease. Cell Mol Life Sci 2005;62:281-292
56. Rupprecht R, di Michele F, Hermann B, et al. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res Brain Res Rev 2001;37:59-67
57. Wisniewski AB, Nguyen TT, Dobs AS. Evaluation of high-dose estrogen and high-dose estrogen plus methyltestosterone treatment on cognitive task performance in postmenopausal women. Horm Res 2002;58:150-155
58. Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345-357
59. Hickok LR, Toomey C, Speroff L. A comparison of esterified estrogens with and without methyltestosterone: effects on endometrial histology and serum lipoproteins in postmenopausal women. Obstet Gynecol 1993;82:919-924
60. Simon J, Klaiber E, Wiita B, Bowen A, Yang HM. Differential effects of estrogen-androgen and estrogen-only therapy on vasomotor symptoms, gonadotropin secretion, and endogenous androgen bioavailability in postmenopausal women. Menopause 1999;6:138-146
61. Sherwin BB, Gelfand MM. Effects of parenteral administration of estrogen and androgen on plasma hormone levels and hot flushes in the surgical menopause. Am J Obstet Gynecol 1984;148:552-557
62. Christiansen K. Behavioural effects of androgen in men and women. J Endocrinol 2001;170:39-48
63. Sherwin BB, Gelfand MM. Sex steroids and affect in the surgical menopause: a double-blind, cross-over study. Psychoneuroendocrinology 1985;10:325-335
64. Wu FCW, von Eckardstein A. Androgens and coronary artery disease. In: Bagatell C, Bremner W, eds. Androgens in Health and Disease. Totowa, NJ: Humana Press; 2003:191-220
65. Farish E, Fletcher C, Hart D, et al. The effects of hormone implants on serum lipoproteins and steroid hormones in bilaterally oophorectomised women. Acta Endocrinol (Copenh) 1984;106:116-120
66. Luciano A, Miller B, Sequenzia L, et al. The effect of sublingual micronized estradiol, progesterone and testosterone on serum lipids and apolipoproteins. Paper presented at: the 9th Annual Meeting of the North American Menopause Society; September 17-19, 1998; Toronto, Canada
67. Somboonporn W, Davis SR. Postmenopausal testosterone therapy and breast cancer risk. Maturitas 2004;49:267-275
68. Brinton LA, Hoover R, Fraumeni JF. Jr. Menopausal oestrogens and breast cancer risk: an expanded case-control study. Br J Cancer 1986;54:825-832
69. Ewertz M. Influence of non-contraceptive exogenous and endogenous sex hormones on breast cancer risk in Denmark. Int J Cancer 1988;42:832-838
70. Dimitrakakis C, Jones R, Liu A, Bondy C. Breast cancer incidence in Australian women using testosterone in addition to estrogen replacement. Proceedings of the 85th Annual Meeting of the Endocrine Society. Philadelphia: The Endocrine Society Press; 2003
71. van Kesteren PJ, Asscheman H, Megens JA, Gooren LJ. Mortality and morbidity in transsexual subjects treated with cross-sex hormones. Clin Endocrinol (Oxf) 1997;47:337-342
72. Canadian Task Force for Periodic Health Care. Evidence-based clinical prevention. Available at: http://www.ctfphc. org. Accessed June 27, 2005