High glucose activates nuclear factor of activated T cells in native vascular smooth muscle

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 4, 2006, Pages 794-800

  Nilsson, Jenny ^a   Nilsson, Lisa M ^a   Chen, Yung Wu ^c   Molkentin, Jeffery D ^d   Erlinge, David ^b   Gomez, Maria F ^a  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c ABBOTT LABORATORIES   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Extracellular nucleotides; GSK 3; High glucose; NFAT; Vascular smooth muscle

Indexed keywords

A 285222; APYRASE; CALCINEURIN INHIBITOR; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN A; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH PROMOTOR; NIFEDIPINE; NUCLEOTIDASE; NUCLEOTIDE; PROTEIN INHIBITOR; PURINE P2Y RECEPTOR; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; VASOCONSTRICTOR AGENT; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CONFOCAL IMMUNOFLUORESCENCE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; METABOLIC SENSOR; MOUSE; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; SENSOR; SIGNAL TRANSDUCTION; VASCULAR DISEASE; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; CALCIUM SIGNALING; CEREBRAL ARTERIES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; NFATC TRANSCRIPTION FACTORS; PYRAZOLES; RECEPTORS, PURINERGIC P2; TRANS-ACTIVATION (GENETICS); URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE; VASOCONSTRICTION;

EID: 33646679107     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000209513.00765.13     Document Type: Article

References (37)

1. Lawrence MC, Bhatt HS, Easom RA. NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1. Diabetes. 2002;51:691-698.
2. Gomez MF, Stevenson AS, Bonev AD, Hill-Eubanks DC, Nelson MT. Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle. J Biol Chem. 2002;277:37756-37764.
3. Liu Z, Zhang C, Dronadula N, Li Q, Rao GN. Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model. J Biol Chem. 2005;280:14700-14708.
4. Rao A, Luo C, Hogan PG. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-747.
5. Mattila PS, Ullman KS, Fiering S, Emmel EA, McCutcheon M, Crabtree GR, Herzenberg LA. The actions of cyclosporin A and FK506 suggest a novel step in the activation of T lymphocytes. EMBO J. 1990;9: 4425-4433.
6. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998;392:186-190.
7. Chin ER, Olson EN, Richardson JA, Yang Q, Humphries C, Shelton JM, Wu H, Zhu W, Bassel-Duby R, Williams RS. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 1998;12:2499-2509.
8. 2+/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 2001;105:863-875.
9. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, Grant SR, Olson EN. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998;93:215-228.
10. Vyas DR, Spangenburg EE, Abraha TW, Childs TE, Booth FW. GSK-3beta negatively regulates skeletal myotube hypertrophy. Am J Physiol Cell Physiol. 2002;283:C545-C551.
11. Amberg GC, Rossow CF, Navedo MF, Santana LF NFATc3 regulates Kv2.1 expression in arterial smooth muscle. J Biol Chem. 2004:M408789200.
12. Erlinge D, Yoo H, Edvinsson L, Reis DJ, Wahlestedt C. Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. Am J Physiol Heart Circ Physiol. 1993;265:H1089-H1097.
13. Hou M, Harden TK, Kuhn CM, Baldetorp B, Lazarowski E, Pendergast W, Moller S, Edvinsson L, Erlinge D. UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors. Am J Physiol Heart Circ Physiol 2002;282:H784-H792.
14. 2+-dependent NFATc3 nuclear accumulation in vascular smooth muscle: role of JNK2 and Crm-1. J Biol Chem. 2003;278:46847-46853.
15. Beals CR, Sheridan CM, Turck CW, Gardner P, Crabtree GR. Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science. 1997;275:1930-1933.
16. Antos CL, McKinsey TA, Frey N, Kutschke W, McAnally J, Shelton JM, Richardson JA, Hill JA, Olson EN. Activated glycogen synthase-3beta suppresses cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2002;99:907-912.
17. Cohen P, Goedert M. GSK3 inhibitors: development and therapeutic potential. Nat Rev Drug Discov. 2004;3:479.
18. Lipskaia L, Pourci M-L, Delomenie C, Combettes L, Goudouneche D, Paul J-L, Capiod T, Lompre A-M. Phosphatidylinositol 3-kinase and calcium-activated transcription pathways are required for VLDL-induced smooth muscle cell proliferation. Circ Res. 2003;92:1115-1122.
19. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004;94:110-118.
20. Djuric SW, BaMaung NY, Basha A, Liu H, Luly JR, Madar DJ, Sciotti RJ, Tu NP, Wagenaar FL, Wiedeman PE, Zhou X, Ballaron S, Bauch J, Chen YW, Chiou XG, Fey T, Gauvin D, Gubbins E, Hsieh GC, Marsh KC, Mollison KW, Pong M, Shaughnessy TK, Sheets MP, Smith M, Trevillyan JM, Warrior U, Wegner CD, Carter GW. 3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator. J Med Chem. 2000;43:2975-2981.
21. Trevillyan JM, Chiou XG, Chen YW, Ballaron SJ, Sheets MP, Smith ML, Wiedeman PE, Warrior U, Wilkins J, Gubbins EJ, Gagne GD, Fagerland J, Carter GW, Luly JR, Mollison KW, Djuric SW. Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds. J Biol Chem. 2001;276:48118-48126.
22. + channel modulation in arterial smooth muscle. Acta Physiol Scand. 1998;164:549-557.
23. 2+]i elevation in rat basilar smooth muscle cells. Stroke. 1997;28:2053-2059.
24. Erlinge D. Extracellular ATP. A central player in the regulation of vascular smooth muscle phenotype. Focus on "dual role of PKA in phenotype modulation of vascular smooth muscle cells by extracellular ATP." Am J Physiol Cell Physiol. 2004;287:C260-C262.
25. Liu Z, Wu Y, Nicklas EW, Jahn LA, Price WJ, Barrett EJ. Unlike insulin, amino acids stimulate p70S6K but not GSK-3 or glycogen synthase in human skeletal muscle. Am J Physiol Endocrinol Metab. 2004;286:E523-E528.
26. Birsan T, Dambrin C, Marsh KC, Jacobsen W, Djuric SW, Mollison KW, Christians U, Carter GW, Morris RE. Preliminary in vivo pharmacokinetic and pharmacodynamic evaluation of a novel calcineurin-independent inhibitor of NFAT. Transpl Int. 2004;3:145-150.
27. Lazarowski ER, Boucher RC, Harden TK. Mechanisms of release of nucleotides and integration of their action as P2X- and P2Y-receptor activating molecules. Mol Pharmacol. 2003;64:785-795.
28. Parodi J, Flores C, Aguayo C, Rudolph MI, Casanello P, Sobrevia L. Inhibition of nitrobenzylthioinosine-sensitive adenosine transport by elevated D-glucose involves activation of P2Y2 purinoceptors in human umbilical vein endothelial cells. Circ Res. 2002;90:570-577.
29. Hellman B, Dansk H, Grapengiesser E. Pancreatic {beta}-cells communicate via intermittent release of ATP. Am J Physiol Endocrinol Metab. 2004;286:E759-E765.
30. Malmsjo M, Hou M, Pendergast W, Erlinge D, Edvinsson L. The stable pyrimidines UDP[beta]S and UTP[gamma]S discriminate between contractile cerebrovascular P2 receptors. Eur J Pharmacol. 2003;458:305-311.
31. Malmsjo M, Hou M, Pendergast W, Erlinge D, Edvinsson L. Potent P2Y6 receptor mediated contractions in human cerebral arteries. BMC Pharmacol. 2003;3:4.
32. Barbagallo M, Shan J, Pang PK, Resnick LM. Glucose-induced alterations of cytosolic free calcium in cultured rat tail artery vascular smooth muscle cells. J Clin Invest. 1995;95:763-767.
33. Gonzalez Bosc LV, Wilkerson MK, Bradley KN, Eckman DM, Hill-Eubanks DC, Nelson MT. Intraluminal pressure is a stimulus for NFATc3 nuclear accumulation: role of calcium, endothelium-derived nitric oxide, and cGMP-dependent protein kinase. J Biol Chem. 2004;279:10702-10709.
34. Hall JL, Chatham JC, Eldar-Finkelman H, Gibbons GH. Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis: role of GSK3{beta}. Diabetes. 2001;50:1171-1179.
35. Seye CI, Kong Q, Erb L, Garrad RC, Krugh B, Wang M, Turner JT, Sturek M, Gonzalez FA, Weisman GA. Functional P2Y2 nucleotide receptors mediate uridine 5′-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries. Circulation. 2002;106:2720-2726.
36. Kereiakes DJ, Young JJ Percutaneous coronary revascularization of diabetic patients in the era of drug-eluting stents. Rev Cardiovasc Med. 2005;6(suppl 1):S48-S58.
37. Davidson JA. Treatment of the patient with diabetes: importance of maintaining target HbA(1c) levels. Curr Med Res Opin. 2004;20:1919-1927.