HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury

Resuscitation

Volumn 54, Issue 1, 2002, Pages 77-87

  Katz, Laurence M ^a   Manning, James E ^a   McCurdy, Shane ^a   Pearce, L Bruce ^b   Gawryl, Maria S ^b   Wang, Yuanfan ^a   Brown, Chad ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b Biopure Corporation   (United States)

Author keywords

Fluid therapy; Hemorrhage; Outcome; Resuscitation; Shock; Trauma

Indexed keywords

HETASTARCH; POLYMERIZED HEMOGLOBIN;

ABDOMINAL BLUNT TRAUMA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLUID THERAPY; HEART INDEX; HEMODYNAMICS; HEMORRHAGIC SHOCK; LACERATION; LIVER HEMORRHAGE; LIVER INJURY; LUNG ARTERY PRESSURE; LUNG CAPILLARY PRESSURE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; RESUSCITATION; SURVIVAL; SURVIVAL TIME; SWINE; TREATMENT OUTCOME;

ANIMALS; BLOOD PRESSURE; BLOOD SUBSTITUTES; BLOOD VOLUME; DISEASE MODELS, ANIMAL; HEMOGLOBINS; HETASTARCH; LIVER; RESUSCITATION; SHOCK, HEMORRHAGIC; SURVIVAL ANALYSIS; SWINE;

EID: 0036294243     PISSN: 03009572     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-9572(02)00053-9     Document Type: Article

References (30)

1. Predictors of outcome in patients who have sustained trauma and who undergo emergency thoracotomy
2. Cardiac performance in hemorrhagic shock
3. Injuries of the liver: A series of 338 patients treated by an accident service
4. Host responses in mediating sepsis and adult respiratory distress syndrome
5. Does initial management of polytrauma patients have an effect on the development of multiple organ failure? Evaluation of preclinical and clinical data of 1112 polytrauma patients
6. Risk factors for multiorgan failure: A case control study
7. The detrimental effects of intravenous crystalloid after aortotomy in swine
8. Uncompensated blood loss is not tolerated during acute normovolemic hemodilution in anesthetized pigs
9. Effects of hemodilution on long-term survival in an uncontrolled hemorrhagic shock model in rats
10. An outcome model of severe hemorrhage and liver injury in swine
11. Comparison of cardiorespiratory effects of crystalline hemoglobin, whole blood, albumin, and Ringer's lactate in the resuscitation of hemorrhagic shock in dogs
12. A comparison of resuscitation with packed red blood cells and whole blood following hemorrhagic shock in canines
13. Overview of preclinical and clinical efficacy of Biopure's HBOCs
14. Hemoglobin-based oxygen carrier reduces intraoperative allogeneic blood requirement during abdominal aneurysm repair
15. Greater maximal myocardial oxygen delivery after hemodilution with polymerized bovine hemoglobin blood substitute
16. Release of anti-inflammatory mediators after major torso trauma correlates with the development of postinjury multiple organ failure
17. Bovine hemoglobin-based oxygen carrier (HBOC-201) for resuscitation of uncontrolled, exsanguinating liver injury in swine
18. Factors that influence the operative mortality after blunt hepatic injury
19. Liver function and morphology after resuscitation from severe hemorrhagic shock with hemoglobin solutions or autologous blood
20. Initiators and propagators of the metabolic response to injury
21. Randomized blinded study of aprotinin infusion for liver crush injuries in the pig model
22. Allergen-induced late-phase airways obstruction in the pig: Mediator release and eosinophil recruitment
23. Pulmonary infiltrates, asthma and eosinophilia due to Ascaris suum infestation in man
24. Current aspects in pharmacology of modified hemoglobins
25. The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergency surgery
26. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: A randomized controlled efficacy trial
27. Role of NO mechanism in cardiovascular effects of DCLHb in anesthetized rats
28. A role for endothelium in the pressor response to DCLHb
29. Transfusions of polymerized bovine hemoglobin in a patient with severe autoimmune hemolytic anemia