메뉴 건너뛰기




Volumn 2, Issue 3, 2006, Pages 281-286

Drug trials in pediatric heart failure: Hype or improved clinical science?

Author keywords

Congenital heart disease; Drug trials; Heart failure; Pediatrics

Indexed keywords

AMIODARONE; ANTIHISTAMINIC AGENT; BENZYL ALCOHOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BOSENTAN; BUCINDOLOL; CHLORAMPHENICOL; CORTICOSTEROID; DIETHYLENE GLYCOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; ETANERCEPT; GLUCURONOSYLTRANSFERASE; MOXONIDINE; NORADRENALIN; PHENOBARBITAL; PLACEBO; SULFONAMIDE;

EID: 33646582314     PISSN: 14796678     EISSN: 17448298     Source Type: Journal    
DOI: 10.2217/14796678.2.3.281     Document Type: Article
Times cited : (2)

References (27)
  • 1
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure
    • Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group
    • Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. N. Engl. J. Med. 316, 1429-1435 (1987).
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1429-1435
  • 2
    • 0025913812 scopus 로고
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure
    • The SOLVD Investigators
    • Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N. Engl. J. Med. 325, 293-302 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , pp. 293-302
  • 3
    • 0025770138 scopus 로고
    • A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
    • Cohn JN, Johnson G, Ziesche S et al.: A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N. Engl. J. Med. 325, 303-310 (1991).
    • (1991) N. Engl. J. Med. , vol.325 , pp. 303-310
    • Cohn, J.N.1    Johnson, G.2    Ziesche, S.3
  • 4
    • 10544223267 scopus 로고    scopus 로고
    • Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure
    • MOCHA Investigators
    • Bristow MR, Gilbert EM, Abraham WT et al.: Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators. Circulation 94, 2807-2816 (1996).
    • (1996) Circulation , vol.94 , pp. 2807-2816
    • Bristow, M.R.1    Gilbert, E.M.2    Abraham, W.T.3
  • 5
    • 0029937949 scopus 로고    scopus 로고
    • The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
    • U.S. Carvedilol Heart Failure Study Group
    • Packer M, Bristow MR, Cohn JN et al.: The effect of carvedilol on morbidity and mortality In patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N. Engl. J. Med. 334, 1349-1355 (1996).
    • (1996) N. Engl. J. Med. , vol.334 , pp. 1349-1355
    • Packer, M.1    Bristow, M.R.2    Cohn, J.N.3
  • 6
    • 0033549290 scopus 로고    scopus 로고
    • Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial In Congestive Heart Failure MERIT-HF)
    • Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial In Congestive Heart Failure MERIT-HF). Lancet 353, 2001-2007 (1999).
    • (1999) Lancet , vol.353 , pp. 2001-2007
  • 7
    • 0033514046 scopus 로고    scopus 로고
    • The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): A randomised trial
    • The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 353, 9-13 (1999).
    • (1999) Lancet , vol.353 , pp. 9-13
  • 8
    • 0037159310 scopus 로고    scopus 로고
    • Effect of carvedilol on the morbidity of patients with severe chronic heart failure: Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study
    • Packer M, Fowler MB, Roecker EB et al.: Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106, 2194-2199 (2002).
    • (2002) Circulation , vol.106 , pp. 2194-2199
    • Packer, M.1    Fowler, M.B.2    Roecker, E.B.3
  • 9
    • 0035978801 scopus 로고    scopus 로고
    • A trial of the β-blocker bucindolol in patients with advanced chronic heart failure
    • A trial of the β-blocker bucindolol in patients with advanced chronic heart failure. N. Engl. J. Med. 344, 1659-1667 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1659-1667
  • 10
    • 0036888364 scopus 로고    scopus 로고
    • How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH
    • Anker SD, Coats AJ: How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH. Int. J. Cardiol. 86, 123-130 (2002).
    • (2002) Int. J. Cardiol. , vol.86 , pp. 123-130
    • Anker, S.D.1    Coats, A.J.2
  • 11
    • 0036774973 scopus 로고    scopus 로고
    • Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?
    • Kalra PR, Moon JC, Coats AJ: Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure? Int. J. Cardiol. 85, 195-197 (2002).
    • (2002) Int. J. Cardiol. , vol.85 , pp. 195-197
    • Kalra, P.R.1    Moon, J.C.2    Coats, A.J.3
  • 12
    • 0346730904 scopus 로고    scopus 로고
    • Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON)
    • Cohn JN, Pfeffer MA, Rouleau J et al.: Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). Eur. J. Heart Fail. 5, 659-667 (2003).
    • (2003) Eur. J. Heart Fail. , vol.5 , pp. 659-667
    • Cohn, J.N.1    Pfeffer, M.A.2    Rouleau, J.3
  • 13
    • 10044242021 scopus 로고    scopus 로고
    • Failure of stroke volume augmentation during exercise and dobutamine stress is unrelated to load-independent indexes of right ventricular performance after the Mustard operation
    • Derrick GP, Narang I, White PA et al.: Failure of stroke volume augmentation during exercise and dobutamine stress is unrelated to load-independent indexes of right ventricular performance after the Mustard operation. Circulation 102, II154-II159 (2000).
    • (2000) Circulation , vol.102
    • Derrick, G.P.1    Narang, I.2    White, P.A.3
  • 14
    • 0034771162 scopus 로고    scopus 로고
    • Abnormalities of right ventricular long axis function after atrial repair of transposition of the great arteries
    • Derrick GP, Josen M, Vogel M, Henein MY, Shinebourne EA, Redington AN: Abnormalities of right ventricular long axis function after atrial repair of transposition of the great arteries. Heart 86, 203-206 (2001).
    • (2001) Heart , vol.86 , pp. 203-206
    • Derrick, G.P.1    Josen, M.2    Vogel, M.3    Henein, M.Y.4    Shinebourne, E.A.5    Redington, A.N.6
  • 15
    • 0347052777 scopus 로고    scopus 로고
    • Systemic ventricular function in patients with transposition of the great arteries after atrial repair: A tissue Doppler and conductance catheter study
    • Vogel M, Derrick G, White PA et al.: Systemic ventricular function in patients with transposition of the great arteries after atrial repair: a tissue Doppler and conductance catheter study. J. Am. Coll. Cardiol. 43, 100-106 (2004).
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 100-106
    • Vogel, M.1    Derrick, G.2    White, P.A.3
  • 16
    • 0030805363 scopus 로고    scopus 로고
    • Enalapril does not enhance exercise capacity in patients after Fontan procedure
    • Kouatli AA, Garcia JA, Zellers TM, Weinstein EM, Mahony L: Enalapril does not enhance exercise capacity in patients after Fontan procedure. Circulation 96, 1507-1512 (1997).
    • (1997) Circulation , vol.96 , pp. 1507-1512
    • Kouatli, A.A.1    Garcia, J.A.2    Zellers, T.M.3    Weinstein, E.M.4    Mahony, L.5
  • 17
    • 0035282827 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitors in adults after the Mustard procedure
    • A611
    • Hechter SJ, Fredriksen PM, Liu P et al.: Angiotensin-converting enzyme inhibitors in adults after the Mustard procedure. Am. J Cardiol. 87, 660-663, A611 (2001).
    • (2001) Am. J Cardiol. , vol.87 , pp. 660-663
    • Hechter, S.J.1    Fredriksen, P.M.2    Liu, P.3
  • 18
    • 27144506750 scopus 로고    scopus 로고
    • Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: A multicenter, randomized, placebo-controlled clinical trial
    • Dore A, Houde C, Chan KL et al.: Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial. Circulation 112, 2411-2416 (2005).
    • (2005) Circulation , vol.112 , pp. 2411-2416
    • Dore, A.1    Houde, C.2    Chan, K.L.3
  • 19
    • 7544251048 scopus 로고    scopus 로고
    • Decline in ventricular function and clinical condition after Mustard repair
    • Derrick G, Deanfield JE: Decline in ventricular function and clinical condition after Mustard repair. Eur. Heart J. 25, 1863-1864 (2004).
    • (2004) Eur. Heart J. , vol.25 , pp. 1863-1864
    • Derrick, G.1    Deanfield, J.E.2
  • 21
    • 0036141173 scopus 로고    scopus 로고
    • Prophylactic intravenous use of milrinone after cardiac operation in pediatrics (PRIMACORP) study. Prophylactic intravenous use of milrinone after cardiac operation in pediatrics
    • Hoffman TM, Wernovsky G, Atz AM et al.: Prophylactic intravenous use of milrinone after cardiac operation In pediatrics (PRIMACORP) study. Prophylactic intravenous use of milrinone after cardiac operation in pediatrics. Am. Heart. J. 143, 15-21 (2002).
    • (2002) Am. Heart. J. , vol.143 , pp. 15-21
    • Hoffman, T.M.1    Wernovsky, G.2    Atz, A.M.3
  • 22
    • 0034900663 scopus 로고    scopus 로고
    • End points for cardiovascular drug trials in pediatric patients
    • Sinaiko AR, Lauer RM, Sanders SP: End points for cardiovascular drug trials in pediatric patients. Am. Heart. J. 142, 229-232 (2001).
    • (2001) Am. Heart. J. , vol.142 , pp. 229-232
    • Sinaiko, A.R.1    Lauer, R.M.2    Sanders, S.P.3
  • 23
    • 0242525148 scopus 로고    scopus 로고
    • Ethics of placebo use in pediatric clinical trials: The case of antihypertensive drug studies
    • Flynn JT: Ethics of placebo use in pediatric clinical trials: the case of antihypertensive drug studies. Hypertension 42, 865-869 (20O3).
    • (2003) Hypertension , vol.42 , pp. 865-869
    • Flynn, J.T.1
  • 25
    • 0003916778 scopus 로고    scopus 로고
    • Institute of Medicine: Evans C, Ildstad S (Eds), National Academy Press, Washington, DC, USA
    • Institute of Medicine: Small Clinical Trials: Issues and Challenges. Evans C, Ildstad S (Eds), National Academy Press, Washington, DC, USA (2001).
    • (2001) Small Clinical Trials: Issues and Challenges
  • 26
    • 0034531294 scopus 로고    scopus 로고
    • Challenges in conducting pediatric drug trials
    • Berlin CM Jr: Challenges in conducting pediatric drug trials. J. Allergy Clin. Immunol. 106, S125-S127 (2000).
    • (2000) J. Allergy Clin. Immunol. , vol.106
    • Berlin Jr., C.M.1
  • 27
    • 0348011543 scopus 로고    scopus 로고
    • Pediatric clinical trial experience: Government, child, parent and physician's perspective
    • Salazar JC: Pediatric clinical trial experience: government, child, parent and physician's perspective. Pediatr. Infect. Dis. J. 22, 1124-1127 (2003).
    • (2003) Pediatr. Infect. Dis. J. , vol.22 , pp. 1124-1127
    • Salazar, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.