Pyruvate attenuates myoglobin in vitro toxicity

Toxicological Sciences

Volumn 74, Issue 2, 2003, Pages 345-351

  Valentovic, Monica A ^a   Minigh, Jennifer ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glutathione levels; Lactate dehydrogenase; Myoglobinuria; Pyruvate; Renal dysfunction; Rhadomyolysis; Substance abuse

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; GLUTATHIONE DISULFIDE; LACTATE DEHYDROGENASE; MYOGLOBIN; PYRUVIC ACID;

ANIMAL TISSUE; ARTICLE; ATTENUATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRUSH TRAUMA; ENZYME RELEASE; GLUCONEOGENESIS; IN VITRO STUDY; INCUBATION TIME; KIDNEY SLICE; LIPID PEROXIDATION; MALE; MYOGLOBINURIA; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN LOCALIZATION; RAT; SUBSTANCE ABUSE; TISSUE DISTRIBUTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ANTAGONISM; GLUCONEOGENESIS; GLUCOSE; GLUTATHIONE DISULFIDE; KIDNEY CORTEX; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MYOGLOBIN; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PYRUVIC ACID; RATS; RATS, INBRED F344;

ANIMALIA;

EID: 0041589370     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg135     Document Type: Article

References (33)

1. Andersen, M. E. (1985). Determination of glutathione and glutathione disulfide. Methods in Enzymol. 113, 548-555.
2. Bunger, R., Swindall., B., Brodie, D., Zdunek, H., Stiegler, G., and Walter, G. (1986). Pyruvate attenuation of hypoxia damage in isolated working guinea pig heart. J. Mol. Cell. Cardiol. 18, 423-438.
3. Bywaters, E. G. L., and Beall, D. (1941). Crush injuries with impairment of renal function. Br. Med. J. 1, 427-432.
4. Catherwood, M. A., Powell, L. A., Anderson, P., McMaseter, D., Sharpe, P. C., and Trimble, E. R. (2002). Glucose-induced oxidative stress in mesangial cells. Kidney Intl. 61, 599-608.
5. Cicalese, L., Lee, K., Schraut, W., Watkins, S., Borle, A., and Stanko, R. (1996). Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am. J. Surg. 171, 97-101.
6. David, W. S. (2000). Myoglobinuria. Neurol. Clin. 18, 215-243.
7. Deboer, L. W., Bekx, P. A., Han, L., and Steinke, L. (1993). Pyruvate enhances recovery of rat hearts after ischemia and reperfusion by preventing free radical generation. Am. J. Physiol. 265, H1571-1576.
8. Griffith, O. W. (1980). Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106, 207-212.
9. 2 generation by rat kidney in glycerol-induced renal failure. Am J. Physiol. 257, F440-F445.
10. Hamilton, R. W., Hopkins, M. B., Shihabi, Z. K. (1989). Myoglobinuria, hemoglobinuria, and acute renal failure. Clin. Chem. 35, 1713-1720.
11. Hampel, G., Horstkotte, H., and Rumpf, K. W. (1983). Myoglobinuric renal failure due to drug-induced rhabdomyolysis. Human Toxicol. 2, 197-203.
12. Heyman, S. N., Rosen, S., Fuchs, S., Epstein, F. H., and Brezis, M. (1996). J. Am. Soc. Nephrol. 7, 1066-1074.
13. Holleman, M. A. F. (1904). Notice sur l'action de l'eau oygénée sur les acides acétoniques et sur les diacétones.1.2. Reel. Trav. Chim. Pays-has Belg. 23, 169-171.
14. Kao, K. C., Tsai, Y. H., Lin, M. C., Huang, C. C., Tsao, C. Y., and Chen, Y. C. (2000). Hypokalemic muscular paralysis causing acute respiratory failure due to rhabdomyolysis with renal tubular acidosis in a chronic glue sniffer. J. Toxicol. Clin. Toxicol. 38, 679-681.
15. Kashiwagi, A., Asahina, T., Nishio, Y., Ikebucki, M., Tanaka, Y., Kikkawa, R., and Shigeta, Y. (1996). Glycation, oxidative stress, and scavenger activity: Glucose metabolism and radical scavenger dysfunction in endothelial cells. Diabetes 45(Suppl. 3), S84-86.
16. Lash, L. H., and Jones, D. P. (1996). Mitochondrial toxicity in renal injury. In Methods in Renal Toxicology (R. K. Zalups and L. H. Lash, Eds.), pp. 299-330. CRC Press, Boca Raton, FL.
17. Loper, K. A. (1989). Clinical toxicology of cocaine. Med. Toxicol. Adverse Drug Exp. 4, 174-185.
18. Mallet, R. T., Squires, J. E., Bhatia, S., and Sun, J. (2002). Pyruvate resotres contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium. J. Mol. Cell. Cardio. 34, 1173-1184.
19. Minigh, J. L., and Valentovic, M. A. (2003). Characterization of myoglobin cytotoxicity in renal cortical slices from Fischer-344 rats. Toxicology 187, 77-87.
20. Sagone, Jr., A. L., Greenwald, J., Kraut, E. H., Bianchine, J, and Singh, D. (1983). Glucose: A role as a free radical scavenger in biological systems. J. Lab. Clin. Med. 101, 97-104.
21. Salahudeen, A. K., Clark, E. C., and Nath, K. A. (1991). Hydrogen peroxide-induced renal injury: A protective role for pyruvate in vitro and in vivo. J. Clin. Invest. 88, 1886-1893.
22. Shah, S. V., and Walker, P. D. (1988). Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am. J. Physiol. 24, F438-F443.
23. Shigemoto, T., Rinka, H., Matsuo, Y., Kaji, A., Tsukioka, K., Ukai, T., and Shimaoka, H. (1997). Blood purification for crush syndrome. Renal Failure 19, 711-719.
24. Ullrich, K. J., and Papavassiliou, F. (1985). Contraluminal transport of hexoes in the proximal convolution of the rat kidney in situ. Pflugers Arch. 404, 150-156.
25. Valentovic, M. A., Ball, J. G., Anestis, D., Beers, K., Madan, E., Hubbard, J. L., and Rankin, G. O. (1992). Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats. Toxicology 75, 121-131.
26. Valentovic, M. A., Ball, J. G., Sun, H., and Rankin, G. O. (2002). Characterization of 2-amino-4,5-dichlorophenol (2A45CP) in vitro toxicity in renal cortical slices from male Fischer-344 rats. Toxicology 172, 113-123.
27. Vanholder, R., Sever, M. S., Erek, E., and Lameire, N. (2000). Rhabdomyolysis. J. Am. Soc. Nephrol. 11, 1533-1561.
28. Welch, R. D., Todd, K., and Krause, G. S. (1991). Incidence of cocaine-associated rhabdomyolysis. Ann. Emerg. Med. 20, 154-157.
29. Yoon, H. H., and Kim, K. H. (1994). High glucose can induce lipid peroxidation in the isolated rat glomeruli. Kidney Int. 46, 1620-1626.
30. Zager, R. A. (1992). Combined mannitol and deferoxamine therapy for myohemoglinuric renal injury and oxidant tubular stress: Mechanistic and therapeutic implications. J. Clin. Invest. 90, 711-719.
31. Zager, R. A. (1996). Mitochondrial free radical production induces lipid peroxidation during myohemoglobinuria. Kidney Int. 49, 741-751.
32. 2, and terminal mitochondrial electron transport. Kidney Int. 51, 728-738.
33. 2 and myoglobin-induced proximal tubular cell attack. Kidney Int. 53, 1661-1672.