The mechanism of M.Hhal DNA C5 cytosine methyltransferase enzyme: A quantum mechanics/molecular mechanics approach

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 16, 2006, Pages 6148-6153

  Zhang, Xiaodong ^a   Bruice, Thomas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Computational

Indexed keywords

5 METHYL 6 CYSTEINE 5,6 DIHYDROCYTOSINE; 6 CYSTEINE 3 HYDROCYTOSINE; BACTERIAL ENZYME; BASE; CYSTEINE; CYTOSINE; DNA; DNA METHYLTRANSFERASE; HYDROGEN; HYDROXIDE; M.HHAI ENZYME; S ADENOSYLMETHIONINE; SOLVENT; UNCLASSIFIED DRUG; WATER; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA MODIFICATION METHYLASE HHAI; SITE SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE SPECIFIC);

ADDITION REACTION; ARTICLE; CALCULATION; CATALYSIS; CATALYST; DNA METHYLATION; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME STRUCTURE; EQUILIBRIUM CONSTANT; MOLECULAR MECHANICS; PH; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTUM MECHANICS; SOLVATION; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; ELECTRICITY; ENZYME ACTIVATION; QUANTUM THEORY;

BACTERIA (MICROORGANISMS);

BINDING SITES; CATALYSIS; CYTOSINE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; ELECTROSTATICS; ENZYME ACTIVATION; QUANTUM THEORY; SITE-SPECIFIC DNA METHYLTRANSFERASE (CYTOSINE-SPECIFIC);

EID: 33646566359     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0601587103     Document Type: Article

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