Enzymatic C5-cytosine methylation of DNA: Mechanistic implications of new crystal structures for HhaI methyltransferase-DNA-AdoHcy complexes

Journal of Molecular Biology

Volumn 261, Issue 5, 1996, Pages 634-645

  O'Gara, Margaret ^a   Klimašauskas, Saulius ^a,c   Roberts, Richard J ^b   Cheng, Xiaodong ^a  

^a W M Keck Structural Biology Laboratory   (United States)

^b NEW ENGLAND BIOLABS   (United States)

^c VILNIUS UNIVERSITY   (Lithuania)

Author keywords

Base flipping; C5 proton elimination; C5 cytosine methyltransfer reaction; N3 protonation; Water mediated interaction

Indexed keywords

5 METHYLDEOXYCYTIDINE; CYTOSINE; DEOXYCYTIDINE; DNA; DNA METHYLTRANSFERASE; S ADENOSYLHOMOCYSTEINE;

ARTICLE; CRYSTAL STRUCTURE; DNA HELIX; DNA METHYLATION; DNA PROTEIN COMPLEX; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTON TRANSPORT;

EID: 0030572656     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0489     Document Type: Article

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