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Volumn 33, Issue SUPPL. 5, 2006, Pages 15-22

Novel Therapeutic Strategies With Alemtuzumab for Chronic Lymphocytic Leukemia

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; ANTINEOPLASTIC AGENT; COTRIMOXAZOLE; IMMUNOMODULATING AGENT; VALACICLOVIR;

EID: 33646555741     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2006.01.025     Document Type: Article
Times cited : (8)

References (53)
  • 2
    • 0037408455 scopus 로고    scopus 로고
    • Determining the clinical course and outcome in chronic lymphocytic leukemia
    • Rai K.R., and Chiorazzi N. Determining the clinical course and outcome in chronic lymphocytic leukemia. N Engl J Med 348 (2003) 1797-1799
    • (2003) N Engl J Med , vol.348 , pp. 1797-1799
    • Rai, K.R.1    Chiorazzi, N.2
  • 3
    • 0028307594 scopus 로고
    • French Cooperative Group on Chronic Lymphocytic Leukemia. Is the CHOP regimen a good treatment for advanced CLL? Results from two randomized clinical trials
    • French Cooperative Group on Chronic Lymphocytic Leukemia
    • French Cooperative Group on Chronic Lymphocytic Leukemia. French Cooperative Group on Chronic Lymphocytic Leukemia. Is the CHOP regimen a good treatment for advanced CLL? Results from two randomized clinical trials. Leuk Lymphoma 13 (1994) 449-456
    • (1994) Leuk Lymphoma , vol.13 , pp. 449-456
  • 4
    • 0003108715 scopus 로고    scopus 로고
    • High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial
    • Jaksic B., Brugiatelli M., Krc I., et al. High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Results of an international multicenter randomized trial. International Society for Chemo-Immunotherapy, Vienna. Cancer 79 (1997) 2107-2114
    • (1997) International Society for Chemo-Immunotherapy, Vienna. Cancer , vol.79 , pp. 2107-2114
    • Jaksic, B.1    Brugiatelli, M.2    Krc, I.3
  • 5
    • 0035889147 scopus 로고    scopus 로고
    • Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients
    • Leporrier M., Chevret S., Cazin B., et al. Randomized comparison of fludarabine, CAP, and ChOP in 938 previously untreated stage B and C chronic lymphocytic leukemia patients. Blood 98 (2001) 2319-2325
    • (2001) Blood , vol.98 , pp. 2319-2325
    • Leporrier, M.1    Chevret, S.2    Cazin, B.3
  • 6
    • 0032529509 scopus 로고    scopus 로고
    • Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy
    • Keating M.J., O'Brien S., Lerner S., et al. Long-term follow-up of patients with chronic lymphocytic leukemia (CLL) receiving fludarabine regimens as initial therapy. Blood 92 (1998) 1165-1171
    • (1998) Blood , vol.92 , pp. 1165-1171
    • Keating, M.J.1    O'Brien, S.2    Lerner, S.3
  • 7
    • 15844368449 scopus 로고    scopus 로고
    • Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia
    • The French Cooperative Group on CLL
    • Johnson S., Smith A.G., Loffler H., et al., The French Cooperative Group on CLL. Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemia. Lancet 347 (1996) 1432-1438
    • (1996) Lancet , vol.347 , pp. 1432-1438
    • Johnson, S.1    Smith, A.G.2    Loffler, H.3
  • 8
    • 0034649696 scopus 로고    scopus 로고
    • Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
    • Rai K.R., Peterson B.L., Appelbaum F.R., et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N Eng J Med 343 (2000) 1750-1757
    • (2000) N Eng J Med , vol.343 , pp. 1750-1757
    • Rai, K.R.1    Peterson, B.L.2    Appelbaum, F.R.3
  • 9
    • 0034614551 scopus 로고    scopus 로고
    • Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway
    • Genini D., Budihardjo I., Plunkett W., et al. Nucleotide requirements for the in vitro activation of the apoptosis protein-activating factor-1-mediated caspase pathway. J Biol Chem 275 (2000) 29-34
    • (2000) J Biol Chem , vol.275 , pp. 29-34
    • Genini, D.1    Budihardjo, I.2    Plunkett, W.3
  • 10
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D., Adachi S., Chao Q., et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood 96 (2000) 3537-3543
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3
  • 11
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh S.Y., Ikeda M., Taya Y., et al. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91 (1997) 325-334
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.Y.1    Ikeda, M.2    Taya, Y.3
  • 12
    • 10744223348 scopus 로고    scopus 로고
    • Characterisation of TP53 abnormalities in chronic lymphocytic leukaemia
    • Thornton P.D., Gruszka-Westwood A.M., Hamoudi R.A., et al. Characterisation of TP53 abnormalities in chronic lymphocytic leukaemia. Hematol J 5 (2004) 47-54
    • (2004) Hematol J , vol.5 , pp. 47-54
    • Thornton, P.D.1    Gruszka-Westwood, A.M.2    Hamoudi, R.A.3
  • 13
    • 0026561988 scopus 로고
    • Mutations of the p53 gene in B-cell chronic lymphocytic leukemia. A report on 39 cases with cytogenetic analysis
    • Fenaux P., Preudhomme C., Lai J.L., et al. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia. A report on 39 cases with cytogenetic analysis. Leukemia 6 (1992) 246-250
    • (1992) Leukemia , vol.6 , pp. 246-250
    • Fenaux, P.1    Preudhomme, C.2    Lai, J.L.3
  • 14
    • 0032973524 scopus 로고    scopus 로고
    • Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders. Frequent occurrence of dicentric rearrangements and possible association with adverse outcome
    • Callet-Bauchu E., Salles G., Gazzo S., et al. Translocations involving the short arm of chromosome 17 in chronic B-lymphoid disorders. Frequent occurrence of dicentric rearrangements and possible association with adverse outcome. Leukemia 13 (1999) 460-468
    • (1999) Leukemia , vol.13 , pp. 460-468
    • Callet-Bauchu, E.1    Salles, G.2    Gazzo, S.3
  • 15
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G., Heerema N.A., Flinn I.W., et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 103 (2004) 3278-3281
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 16
    • 0036335916 scopus 로고    scopus 로고
    • Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia
    • Keating M.J., O'Brien S., Kontoyiannis D., et al. Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia. Leuk Lymphoma 43 (2002) 1755-1762
    • (2002) Leuk Lymphoma , vol.43 , pp. 1755-1762
    • Keating, M.J.1    O'Brien, S.2    Kontoyiannis, D.3
  • 17
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia
    • European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Österborg A., Dyer M.J., Bunjes D., et al., European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. J Clin Oncol 15 (1997) 1567-1574
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Österborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 18
    • 0344900786 scopus 로고    scopus 로고
    • CAMPATH-1H therapy for patients with refractory chronic lymphocytic leukaemia
    • (abstr)
    • Rawstron A., Davies C., Evans P., et al. CAMPATH-1H therapy for patients with refractory chronic lymphocytic leukaemia. Blood 90 (1997) 2356 (abstr)
    • (1997) Blood , vol.90 , pp. 2356
    • Rawstron, A.1    Davies, C.2    Evans, P.3
  • 19
    • 0009351039 scopus 로고    scopus 로고
    • Campath-1H in refractory CLL-Complete remission despite p53 gene mutation
    • (abstr)
    • Stilgenbauer S., Scherer K., Krobler A., et al. Campath-1H in refractory CLL-Complete remission despite p53 gene mutation. Blood 98 (2001) 3211 (abstr)
    • (2001) Blood , vol.98 , pp. 3211
    • Stilgenbauer, S.1    Scherer, K.2    Krobler, A.3
  • 20
    • 0036242664 scopus 로고    scopus 로고
    • Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia
    • McCune S.L., Gockerman J.P., Moore J.O., et al. Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia. Leuk Lymphoma 43 (2002) 1007-1011
    • (2002) Leuk Lymphoma , vol.43 , pp. 1007-1011
    • McCune, S.L.1    Gockerman, J.P.2    Moore, J.O.3
  • 21
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai K.R., Freter C.E., Mercier R.J., et al. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol 20 (2002) 3891-3897
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.R.1    Freter, C.E.2    Mercier, R.J.3
  • 22
    • 0042071567 scopus 로고    scopus 로고
    • Phase II study of alemtuzumab in chronic lymphoproliferative disorders
    • Ferrajoli A., O'Brien S.M., Cortes J.E., et al. Phase II study of alemtuzumab in chronic lymphoproliferative disorders. Cancer 98 (2003) 773-778
    • (2003) Cancer , vol.98 , pp. 773-778
    • Ferrajoli, A.1    O'Brien, S.M.2    Cortes, J.E.3
  • 23
    • 0038315030 scopus 로고    scopus 로고
    • Patients with refractory B-CLL and T-PLL treated with alemtuzumab (CamPath) on a compassionate basis. A report on efficacy and safety of CAM 511 trial
    • (abstr)
    • Rai K.R., Keating M.J., Coutre S., et al. Patients with refractory B-CLL and T-PLL treated with alemtuzumab (CamPath) on a compassionate basis. A report on efficacy and safety of CAM 511 trial. Blood 100 (2002) 3165 (abstr)
    • (2002) Blood , vol.100 , pp. 3165
    • Rai, K.R.1    Keating, M.J.2    Coutre, S.3
  • 24
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine. Results of a large international study
    • Keating M.J., Flinn I., Jain V., et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine. Results of a large international study. Blood 99 (2002) 3554-3561
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 25
    • 27144510745 scopus 로고    scopus 로고
    • Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL. Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG)
    • (abstr)
    • Stilgenbauer S., Winkler D., Krober A., et al. Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL. Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG). Blood 104 (2004) 478 (abstr)
    • (2004) Blood , vol.104 , pp. 478
    • Stilgenbauer, S.1    Winkler, D.2    Krober, A.3
  • 26
    • 3843129540 scopus 로고    scopus 로고
    • Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
    • Hale G., Rebello P., Brettman L., et al. Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration. Blood 104 (2004) 948-955
    • (2004) Blood , vol.104 , pp. 948-955
    • Hale, G.1    Rebello, P.2    Brettman, L.3
  • 27
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J., Kimby E., Bjorkholm M., et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 100 (2002) 768-773
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 28
    • 33646539949 scopus 로고    scopus 로고
    • Preliminary safety and efficacy report of randomized trial of alemtuzumab vs. chlorambucil as front-line in 297 patients with progressive B-cell chronic lymphocytic leukemia
    • Hillmen P., Skotnicki A., Robak T., et al. Preliminary safety and efficacy report of randomized trial of alemtuzumab vs. chlorambucil as front-line in 297 patients with progressive B-cell chronic lymphocytic leukemia. Blood 104 (2004) 2505
    • (2004) Blood , vol.104 , pp. 2505
    • Hillmen, P.1    Skotnicki, A.2    Robak, T.3
  • 29
    • 0035412369 scopus 로고    scopus 로고
    • Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy
    • Rawstron A.C., Kennedy B., Evans P.A., et al. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood 98 (2001) 29-35
    • (2001) Blood , vol.98 , pp. 29-35
    • Rawstron, A.C.1    Kennedy, B.2    Evans, P.A.3
  • 30
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P., Kennedy B., Lucas G., et al. Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol 23 (2005) 2971-2979
    • (2005) J Clin Oncol , vol.23 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3
  • 31
    • 0037860441 scopus 로고    scopus 로고
    • A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) patients with active disease. Cancer and Leukemia Group B (CALGB) study 19901
    • (abstr)
    • Rai K.R., Byrd J., Peterson B., et al. A phase II trial of fludarabine followed by alemtuzumab (Campath-1H) in previously untreated chronic lymphocytic leukemia (CLL) patients with active disease. Cancer and Leukemia Group B (CALGB) study 19901. Blood 100 (2002) 772 (abstr)
    • (2002) Blood , vol.100 , pp. 772
    • Rai, K.R.1    Byrd, J.2    Peterson, B.3
  • 32
    • 14244262359 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL). CALGB Study 19901
    • (abstr)
    • Rai K.R., Byrd J., Peterson B., et al. Subcutaneous alemtuzumab following fludarabine for previously untreated patients with chronic lymphocytic leukemia (CLL). CALGB Study 19901. Blood 102 (2003) 2506 (abstr)
    • (2003) Blood , vol.102 , pp. 2506
    • Rai, K.R.1    Byrd, J.2    Peterson, B.3
  • 33
    • 1942442044 scopus 로고    scopus 로고
    • Alemtuzumab for minimal residual disease in CLL
    • (abstr)
    • O'Brien S., Gribben J.G., Thomas D.A., et al. Alemtuzumab for minimal residual disease in CLL. Blood 102 (2003) 371 (abstr)
    • (2003) Blood , vol.102 , pp. 371
    • O'Brien, S.1    Gribben, J.G.2    Thomas, D.A.3
  • 34
    • 0344236261 scopus 로고    scopus 로고
    • Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia
    • O'Brien S.M., Kantarjian H.M., Thomas D.A., et al. Alemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemia. Cancer 98 (2003) 2657-2663
    • (2003) Cancer , vol.98 , pp. 2657-2663
    • O'Brien, S.M.1    Kantarjian, H.M.2    Thomas, D.A.3
  • 35
    • 33646572060 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab after a response to fludarabine in patients with CLL. Confirmation of the efficacy to purge residual disease
    • (abstr)
    • Montillo M., Tedeschi A., Rossi V., et al. Consolidation with alemtuzumab after a response to fludarabine in patients with CLL. Confirmation of the efficacy to purge residual disease. Leuk Lymphoma 46 suppl 1 (2005) S93 (abstr)
    • (2005) Leuk Lymphoma , vol.46 , Issue.SUPPL. 1
    • Montillo, M.1    Tedeschi, A.2    Rossi, V.3
  • 36
    • 2942694373 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-Experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG)
    • Wendtner C.M., Ritgen M., Schweighofer C.D., et al. Consolidation with alemtuzumab in patients with chronic lymphocytic leukemia (CLL) in first remission-Experience on safety and efficacy within a randomized multicenter phase III trial of the German CLL Study Group (GCLLSG). Leukemia 18 (2004) 1093-1101
    • (2004) Leukemia , vol.18 , pp. 1093-1101
    • Wendtner, C.M.1    Ritgen, M.2    Schweighofer, C.D.3
  • 37
    • 33645990832 scopus 로고    scopus 로고
    • Consolidation with alemtuzumab in first remission induces pronounced MRD reduction and clinical remissions-Update on randomized phase III trial of the German CLL Study Group (GCLLSG)
    • (abstr)
    • Ritgen M., Schweighofer C., Fingerle-Rowson G., et al. Consolidation with alemtuzumab in first remission induces pronounced MRD reduction and clinical remissions-Update on randomized phase III trial of the German CLL Study Group (GCLLSG). Blood 104 (2004) 2506 (abstr)
    • (2004) Blood , vol.104 , pp. 2506
    • Ritgen, M.1    Schweighofer, C.2    Fingerle-Rowson, G.3
  • 38
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. Results of a Phase II trial
    • Elter T., Borchmann P., Schulz H., et al. Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia. Results of a Phase II trial. J Clin Oncol 23 (2005) 7024-7031
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3
  • 39
    • 0034727833 scopus 로고    scopus 로고
    • Genomic aberrations and survival in chronic lymphocytic leukemia
    • Dohner H., Stilgenbauer S., Benner A., et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Eng J Med 343 (2000) 1910-1916
    • (2000) N Eng J Med , vol.343 , pp. 1910-1916
    • Dohner, H.1    Stilgenbauer, S.2    Benner, A.3
  • 40
    • 0028987180 scopus 로고
    • p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic-B-cell leukemias
    • Dohner H., Fishcer K., Bentz M., et al. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic-B-cell leukemias. Blood 85 (1995) 1580-1589
    • (1995) Blood , vol.85 , pp. 1580-1589
    • Dohner, H.1    Fishcer, K.2    Bentz, M.3
  • 41
    • 0027436745 scopus 로고
    • p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
    • El Rouby S., Thomas A., Costin D., et al. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression. Blood 82 (1993) 3452-3459
    • (1993) Blood , vol.82 , pp. 3452-3459
    • El Rouby, S.1    Thomas, A.2    Costin, D.3
  • 42
    • 0037850927 scopus 로고    scopus 로고
    • Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy
    • Sturm I., Bosanquet A.G., Hermann S., et al. Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy. Cell Death Diff 10 (2003) 477-484
    • (2003) Cell Death Diff , vol.10 , pp. 477-484
    • Sturm, I.1    Bosanquet, A.G.2    Hermann, S.3
  • 43
    • 0037228952 scopus 로고    scopus 로고
    • Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab
    • Byrd J.C., Smith L., Hackbarth M.L., et al. Interphase cytogenetic abnormalities in chronic lymphocytic leukemia may predict response to rituximab. Cancer Res 63 (2003) 36-38
    • (2003) Cancer Res , vol.63 , pp. 36-38
    • Byrd, J.C.1    Smith, L.2    Hackbarth, M.L.3
  • 44
    • 33646598817 scopus 로고    scopus 로고
    • Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia (CLL). Preliminary justification for risk-adapted therapy
    • (abstr)
    • Byrd J.C., Gribben J.G., Peterson B., et al. Select high-risk genetic features predict earlier progression following chemoimmunotherapy with fludarabine and rituximab in chronic lymphocytic leukemia (CLL). Preliminary justification for risk-adapted therapy. Blood 104 (2004) 476 (abstr)
    • (2004) Blood , vol.104 , pp. 476
    • Byrd, J.C.1    Gribben, J.G.2    Peterson, B.3
  • 45
    • 33646576987 scopus 로고    scopus 로고
    • Outcome of treatment with fludarabine versus fludarabine and cyclophosphamide in chronic lymphocytic leukemia (CLL) is adversely implicated by high risk genetic features. results from ECOG 2997
    • (abstr)
    • Grever M.R., Lucas D.M., Dewald G.W., et al. Outcome of treatment with fludarabine versus fludarabine and cyclophosphamide in chronic lymphocytic leukemia (CLL) is adversely implicated by high risk genetic features. results from ECOG 2997. Blood 104 (2004) 3487 (abstr)
    • (2004) Blood , vol.104 , pp. 3487
    • Grever, M.R.1    Lucas, D.M.2    Dewald, G.W.3
  • 46
    • 32644443063 scopus 로고    scopus 로고
    • Clinical, laboratory, and treatment outcome characteristics of chronic lymphocytic leukemia (CLL) patients with p53mutations or del(17p) enrolled in a prospective phase III clinical trial. Short progression free survival, irrespective of fludarabine-based treatment used
    • (abstr)
    • Lucas D.M., Dewald G.W., Neuberg D.S., et al. Clinical, laboratory, and treatment outcome characteristics of chronic lymphocytic leukemia (CLL) patients with p53mutations or del(17p) enrolled in a prospective phase III clinical trial. Short progression free survival, irrespective of fludarabine-based treatment used. Blood 104 (2004) 949 (abstr)
    • (2004) Blood , vol.104 , pp. 949
    • Lucas, D.M.1    Dewald, G.W.2    Neuberg, D.S.3
  • 47
    • 27144522767 scopus 로고    scopus 로고
    • Response to therapy and survival in CLL is influenced by genetic markers. preliminary analysis from the LRF CLL4 trial
    • (abstr)
    • Catovsky D., Richards S., Matutes E., et al. Response to therapy and survival in CLL is influenced by genetic markers. preliminary analysis from the LRF CLL4 trial. Blood 104 (2004) 13 (abstr)
    • (2004) Blood , vol.104 , pp. 13
    • Catovsky, D.1    Richards, S.2    Matutes, E.3
  • 48
    • 27144510745 scopus 로고    scopus 로고
    • Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL. Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG)
    • (abstr)
    • Stilgenbauer S., Winkler D., Krober A., et al. Subcutaneous Campath-1H (alemtuzumab) in fludarabine-refractory CLL. Interim analysis of the CLL2H study of the German CLL Study Group (GCLLSG). Blood 104 (2004) 478 (abstr)
    • (2004) Blood , vol.104 , pp. 478
    • Stilgenbauer, S.1    Winkler, D.2    Krober, A.3
  • 49
    • 15244362778 scopus 로고    scopus 로고
    • A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with hemotherapy-refractory chronic lymphocytic leukemia
    • Cortelezzi A., Pasquini M.C., Sarina B., et al. A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with hemotherapy-refractory chronic lymphocytic leukemia. Haematologica 90 (2005) 410-412
    • (2005) Haematologica , vol.90 , pp. 410-412
    • Cortelezzi, A.1    Pasquini, M.C.2    Sarina, B.3
  • 50
    • 33444454890 scopus 로고    scopus 로고
    • Alemtuzumab for chronic lymphocytic leukemia with and without p53 deletions
    • (abstr)
    • Osuji N., Giudice I.D., Matutes E., et al. Alemtuzumab for chronic lymphocytic leukemia with and without p53 deletions. Blood 104 (2004) 2510 (abstr)
    • (2004) Blood , vol.104 , pp. 2510
    • Osuji, N.1    Giudice, I.D.2    Matutes, E.3
  • 52
    • 33646593336 scopus 로고    scopus 로고
    • Varying modes of maintenance therapy with Campath-1H in chronic lymphocytic leukemia (CLL)
    • (abstr)
    • Rai K.R., Janson D., Driscoll N., et al. Varying modes of maintenance therapy with Campath-1H in chronic lymphocytic leukemia (CLL). Blood 103 (2002) 1099 (abstr)
    • (2002) Blood , vol.103 , pp. 1099
    • Rai, K.R.1    Janson, D.2    Driscoll, N.3
  • 53
    • 10744231366 scopus 로고    scopus 로고
    • Maintenance therapy with a monthly injection of alemtuzumab prolongs response duration in patients with refractory B-cell chronic lymphocytic leukemia/small lymphocytic leukemia (B-CLL/SLL)
    • Thieblemont C., Bouafia F., Hornez E., et al. Maintenance therapy with a monthly injection of alemtuzumab prolongs response duration in patients with refractory B-cell chronic lymphocytic leukemia/small lymphocytic leukemia (B-CLL/SLL). Leuk Lymphoma 45 (2004) 711-714
    • (2004) Leuk Lymphoma , vol.45 , pp. 711-714
    • Thieblemont, C.1    Bouafia, F.2    Hornez, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.