Substrate specificity of inner membrane peptidase in yeast mitochondria

Molecular Genetics and Genomics

Volumn 275, Issue 5, 2006, Pages 431-436

  Luo, Wentian ^a   Fang, Hong ^a   Green, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IMMP2L; Inner membrane protease; Mitochondria; Signal peptidase; Substrate specificity; Yeast

Indexed keywords

CYTOCHROME C1; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; PROTEINASE; SIGNAL PEPTIDASE;

AMINO ACID SUBSTITUTION; ARTICLE; DNA LIBRARY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; MITOCHONDRION; MOLECULAR CLONING; NONHUMAN; ORTHOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION SITE; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

ANIMALS; BINDING SITES; CYTOCHROMES C1; ENDOPEPTIDASES; ENZYME PRECURSORS; GLYCEROLPHOSPHATE DEHYDROGENASE; HYDROLYSIS; MICE; MITOCHONDRIAL MEMBRANES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY;

MAMMALIA; MURINAE; SACCHAROMYCES CEREVISIAE;

EID: 33646554209     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-006-0099-7     Document Type: Article

References (24)

1. Anderson S, de Bruijn MH, Coulson AR, Eperon IC, Sanger F, Young IG (1982) Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome. J Mol Biol 156:683-717
2. 5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes. J Cell Biol 135:1501-1513
3. Brown LJ, MacDonald MJ, Lehn DA, Moran SM (1994) Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains. J Biol Chem 269:14363-14366
4. Burri L, Strahm Y, Hawkins C, Gentle IE, Puryer MA, Verhagen A, Callus B, Vaux D, Lithgow T (2005) Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane. Mol Biol Cell 16:2926-2933
5. Chen X, VanValkenburgh C, Fang H, Green N (1999) Signal peptides having standard and nonstandard cleavage sites can be processed by Imp1p of the mitochondrial inner membrane protease. J Biol Chem 274:37750-37754
6. Esser K, Jan PS, Pratje E, Michaelis G (2004) The mitochondrial IMP peptidase of yeast: functional analysis of domains and identification of Gut2 as a new natural substrate. Mol Genet Genomics 271:616-626
7. Guiard B (1985) Structure, expression and regulation of a nuclear gene encoding a mitochondrial protein: the yeast L (+)-lactate cytchrome c oxidoreductase (cytchrome b2). EMBO J 4:3265-3272
8. 5 reductase to two different submitochondrial compartments. Cell 79:829-839
9. von Heijne G (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acids Res 14:4683-4690
10. Jan P-S, Esser K Pratje E, Michaelis G (2000) Som1, a third component of the yeast mitochondrial inner membrane peptidase complex that contains Impl and Imp2. Mol Gen Genet 263:483-491
11. Liang H, Luo W, Green N, Fang H (2004) Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria. J Biol Chem 279:39396-39400
12. Luo W, Chen X, Fang H, Green N (2003) Factors governing nonoverlapping substrate specificity by mitochondrial inner membrane peptidase. J Biol Chem 278:4943-4948
13. Nunnari J, Fox TD, Walter P (1993) A mitochondrial protease with two catalytic subunits of nonoverlapping specificites. Science 262:1997-2004
14. Paetzel M, Karla A, Strynadka NC, Dalbey RE (2002) Signal peptidases. Chem Rev 102:4549-4580
15. Petek E, Windpassinger C, Vincent JB, Cheung J, Boright AP, Scherer SW, Kroisel PM, Wagner K (2001) Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Am J Hum Genet 68:848-858
16. Pratje E, Guiard B (1986) One nuclear gene controls the removal of transient presequences from two yeast proteins: one encoded by the nuclear the other by the mitochodrial genome. EMBO J 5:1313-1317
17. 1 precursor reveals an unusually complex aminoterminal presequence. EMBO J 3:2137-2143
18. Schneider A, Behrens M, Scherer P, Pratje E, Michaelis G, Schatz G (1991) Inner membrane protease 1, an enzyme mediating intramitochondrial protein sorting in yeast. EMBO J 10:247-254
19. Shen LM, Lee JI, Cheng SY, Jutte H, Kuhn A, Dalbey RE (1991) Use of site-directed mutagenesis to define the limits of sequence variation tolerated for processing of the M13 procoat protein by the Escherichia coli leader peptidase. Biochemistry 30:11775-11781
20. Steffens GJ, Buse G (1979) Studies on cytochrome c oxidase (IV): primary structure and function of subunit II. Hoppe-Seyler's Z Physiol Chem 360:613-619
21. 1 gene. J Biol Chem 264:1368-1374
22. 5 reductase gene. Gene 80:353-361
23. Verhagen AM, Ekert PG, Pakusch M, Silke J, Connolly LM, Reid GE, Moritz RL, Simpson RJ, Vaux DL (2000) Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 102:43-53
24. Verner K, Schatz G (1988) Protein translocation across membranes. Science 241:1307-1313