Retrofit decisions within the biopharmaceutical industry: An EBA case study

Food and Bioproducts Processing

Volumn 84, Issue 1 C, 2006, Pages 84-89

  Mustafa, M A ^a   Washbrook, J ^a   Titchener Hooker, N J ^a   Farid, S S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Biopharmaceutical manufacture; Chromatography; Computer aided simulation; Expanded bed adsorption; Process economics; Retrofit

Indexed keywords

BIOTECHNOLOGY; COMPUTER SIMULATION; ECONOMICS; EFFICIENCY; PROCESSING;

BIOPHARMACEUTICAL INDUSTRY; BIOPHARMACEUTICAL MANUFACTURE; EXPANDED BED ADSORPTION; PROCESS ECONOMICS; RETROFIT SOLUTION;

DRUG PRODUCTS PLANTS;

EID: 33646543024     PISSN: 09603085     EISSN: None     Source Type: Journal    
DOI: 10.1205/fbp.05123     Document Type: Article

References (20)

1. Beck, J. and Lewis-Sandy, D., 2000, Process economic modeling for decision-making during process development of therapeutic proteins. Presented at IBC's Production and Economics of Biopharmaceuticals, November 13-15, La Jolla, CA, USA.
2. Clemento, A., 1999, New and integrated approaches to successful accelerated drug development, Drug Inf J, 33: 699-710.
3. Coopers and Lybrand, 1997, Pharmaceuticals creating value by transforming the cost base - our approach.
4. Curbelo, D.R., Garke, G., Guilarte, R.C., Anspach, F.B. and Deckwer, W.-D., 2003, Cost comparison of protein capture from cultivation broths by expanded and packed bed adsorption, Eng Life Sci, 3(10): 406-415.
5. Farid, S., Novais, J.L., Karri, S., Washbrook, J. and Titchener-Hooker, N.J., 2000, A tool for modelling strategic decisions in cell culture manufacturing, Biotechnol Prog, 16(5): 829-836.
6. Farid, S.S., Washbrook, J. and Titchener-Hooker, N.J., 2005, Decision-support tool for assessing bio-manufacturing strategies under uncertainty: stainless steel versus disposable equipment for clinical trial material preparation, Biotechnol Prog, 21(2): 486-497.
7. Gosling, I., 1996, The role of computer simulation in the bioprocessing industry, BioPharm, Jan: 16.
8. Gritsis, D. and Titchener-Hooker, N.J., 1989, Biochemical process simulation, IChemE Symposium Series, 114: 69-77.
9. Johansson, H.J., Jagersten, C. and Shiloach, J., 1996, Large scale recovery and purification of periplasmic recombinant protein from E. Coli using expanded bed adsorption chromatography followed by new ion exchange media, J Biotechnol, 48: 9-14.
10. Lang, H.J., 1948, Simplified approach to preliminary cost estimates, Chem Eng, 55: 112-113.
11. Larsson, L. and Walter, J.K., 2002, Strategies for the development of appropriate harvest methodologies: technologies and economics. Presented at IBC's Production and Economics of Biopharmaceuticals, November 20-21, San Diego, USA.
12. Lim, A.C., Zhou, Y., Washbrook, J., Titchener-Hooker, N.J. and Farid, S., 2004, A decisional-support tool to model the impact of regulatory compliance activities in the biomanufacturing industry, Comput Chem Eng, 28(5): 727-735.
13. Lim, A.C., Zhou, Y., Washbrook, J., Sinclair, A., Fish, B., Francis, R., Titchener-Hooker, N.J. and Farid, S.S., 2005. Application of a decision-support tool to assess pooling strategies in perfusion culture processes under uncertainty. Biotechnol Prog 21(4): 1231-1242.
14. Mustafa, M.A., Washbrook, J., Lim, A.C., Zhou, Y., Titchener-Hooker, N.J., Morton, P., Berezenko, S. and Farid, S.S., 2004, A software tool to assist business-process decision making in the biopharmaceutical industry, Biotechnol Prog, 20: 1096-1102. [Correction: Biotechnol Prog, 2005, 21(1): 320.]
15. Nothelfer, F. and Walter, J.K., 2002, A comparison of STREAMLINE expanded bed adsorption with the combined techniques of filtration and conventional fixed bed chromatography for the capture of an Fc-fusion protein from CHO cell culture. Amersham Biosciences: Application note (STREAMLINE expanded bed adsorption).
16. Pisano, G.P. and Wheelwright, S.C., 1995, High-tech R&D, Harvard Business Review, Sept - Oct: 93-105.
17. Shanklin, T., Roper, K., Yegneswaran, P.K. and Marten, M.R., 2001, Selection of bioprocess simulation software for industrial applications, Biotechnol Bioeng, 72(4): 483-489.
18. Thomas, C.J., 2003, A design approach to biotech process simulations. BioProcess International, 1(10): 32-45.
19. Walter, J., Striffler, U. and Feuser, J., 2000, EBA technology vs conventional primary recovery: technical feasibility and process economics. Proc IBC' s Production and Economics of Biopharmaceuticals, November 13-15, La Jolla, CA, USA.
20. Werner, R.G., 1998, Identification and development of new biopharmaceuticals, Arzneim-Forsch/Drug Res, 48: 523-540.