Efficacious preparation of Biginelli compounds. A comparative study of different reaction techniques

Letters in Organic Chemistry

Volumn 3, Issue 3, 2006, Pages 201-203

  Singh, Kamaljit ^a   Singh, Sukhdeep ^b   Kaur, Paramjit ^b  

^a Department of Applied Chemical Sciences and Technology ^*  (India)

^b GURU NANAK DEV UNIVERSITY   (India)

Author keywords

3,4 dihydropyrimidinones; Biginelli compounds; Calcium channel blockers; Green chemistry; Sonication

Indexed keywords

EID: 33646533405     PISSN: 15701786     EISSN: None     Source Type: Journal    
DOI: 10.2174/157017806775789912     Document Type: Article

References (18)

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17. General procedure An intimate mixture of well ground urea/ thiourea (10 mmol), ethyl acetoacetate (1.3 g, 10 mmol), an appropriate aldehyde (10 mmol) and catalytic amount of an acid (0. 1 mmol) (Table- 1), in a borosil glass test tube (25 ml) was sonicated at 100 ultrasonication power of the instrument The sonicator was set-on, for appropriate time (15-90 min., Table-1). During this time, in most of the reactions, the initial solid mixture got fused and turned into an opaque viscous clear morture and then gradually, turned into solid. At this time the reaction was adjudged complete (TLC) and the contents in the test tube were washed with water and then dissolved in appropriate solvent for re-crystallization of the product.
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