Selective cytotoxicity of recombinant STXA1-GM-CSF protein in hematopoetic cancer cells

Cell Biology and Toxicology

Volumn 22, Issue 3, 2006, Pages 213-219

  Habibi Roudkenar, M ^a   Jafari, A ^a   Oloomi, M ^a   Bouzari, S ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Cancer; Chimeric protein; Cytotoxicity; hGM CSF; Shiga toxin

Indexed keywords

CHIMERIC PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN STXA1 GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; SHIGA TOXIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CELL KILLING; CELL SPECIFICITY; CYTOTOXICITY; DRUG CYTOTOXICITY; DRUG SELECTIVITY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; RECEPTOR BINDING; RECEPTOR BLOCKING; TARGET CELL; VIRUS NEUTRALIZATION;

APOPTOSIS; CELL SURVIVAL; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOLOGIC NEOPLASMS; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; RECOMBINANT PROTEINS;

ANIMALIA;

EID: 33646533343     PISSN: 07422091     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10565-006-0051-y     Document Type: Article

References (19)

1. Al-Jaufy AY, Haddad JA, King SR, McPhee RA, Jackson MP. Cytotoxicity of a Shiga toxin A subunit-CD4 fusion protein to human immunodeficiency virus-infected cells. Infect Immun. 1994;62:956-60.
2. Bendle AE, Shao Y, Davies SM, et al. A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor. Leuk Lymphoma. 1997;25:257-70.
3. Berardi AC, Wang A, Levine JD, Lopez P, Scadden DT. Functional isolation and characterisation of human hemopoietic stem cells. Science. 1995;267:104-8.
4. Budel LM, Touw IP, Delwel R, Clark SC, Lowenberg B. Interlekin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response. Blood. 1989;74:565-71.
5. Chiba S, Shibuya K, Piao Y, et al. Identification and cellular distribution of distinct proteins forming human GM-CSF receptor. Cell Regul. 1990;1:327-35.
6. Frankel AE, Hall PD, Burbage C, et al. Modulation of the apoptotic response of human myeloid leukemia cells of a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein. Blood. 1997;90:3654-61.
7. Frankel AE, Powell BL, Hall PD, Case LD, Kreitman JR. Phase I trial of a novel diphtheria toxin/GMCSF fusion protein (DT388GCSF) for refractory or relapsed acute myeloid leukaemia (AML). Clin Cancer Res. 2002a;8:1004-13.
8. Frankel AE. Receptor upregulation enhances cell surface receptor targeted therapies. Leuk Res. 2002b;26:1069-71.
9. Habibi Roudkenar M, Bouzari S, Oloomi M, Jafari A, Shahrokhi N, Shokrgozar MA. Expression of a chimeric protein containing the catalytic domain of Shiga-like toxin and human granulocyte-macrophage colony-stimulating factor (hGM-CSF) in Escherichia coli and its recognition by reciprocal antibodies. Iranian Biomed J. 2005;9:143-8.
10. Kojio S, Zhang HM, Ohumara M, Gondaira F, Kobayashi N, Yamamoto T. Caspase-3 inactivation and apoptosis induction coupled with the retrograde transport of Shiga toxin: inhibition by brefeldin A. FEMS Immunol Med Microbiol. 2000;29;275-81.
11. Lyne PD, Bamborough TL, Duncan D, Richards WG. Molecular modelling of the GM-CSF and IL-3 receptor complexes. Protein Sci. 1995;4:2223-33.
12. Narayanan S, Suredranath K, Bora N, Surolia A, Karande AA. Ribosome inactivating protein and apoptosis. FEBS Lett. 2005;579:1324-31.
13. Sakamaki K, Miyajima I, Kitamura T, Miyajima A. Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosporylation. EMBO J. 1992;11:3541-9.
14. Skinner LM, Jackson MP. Inhibition of prokaryotic translation by the Shiga toxin enzymatic subunit. Microb Pathog. 1998;24:117-22.
15. Stirpe F. Ribosome-inactivating proteins. Toxicon. 2004;44:371-83.
16. Tada H, Shiho O, Kuroshima K, Koyama M, Tsukamoto K. An improved colorimetric assay for interleukin 2. J Immunol Methods. 1986;9:157-65.
17. Terpstra W, Rozemuller H, Breems DA, et al. Diphtheria toxin fused to granulocyte-macrophage stimulating-factor eliminates acute myeloid leukaemia cells with the potential to initiate leukaemia in immunodeficient mice, but spares normal hemopoietic stem cells. Blood. 1997;90:3735-42.
18. ct GMSF in a Baculovirus expression vector system for biotherapy of GMCSF-receptor sensitive hematologic malignancies. Protein Expr Purif. 1998;13:210-21.
19. + bone marrow cells, differentiating monomyeloid progenitors, and mature blood cell subsets. Blood. 1994;84:764-74.