Antiulcer agents. 6. Analysis of the in vitro biochemical and in vivo gastric antisecretory activity of substituted imidazo[1,2-a]pyridines and related analogues using comparative molecular field analysis and hypothetical active site lattice methodologies

Journal of Medicinal Chemistry

Volumn 40, Issue 4, 1997, Pages 427-436

  Kaminski, James J ^a,b   Doweyko, Arthur M ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Struct Chem/Comp Assisted Drug D ^*  (United States)

^c Drug Metab and Pharmacokin Dept

Author keywords

[No Author keywords available]

Indexed keywords

2 (TRIFLUOROMETHYL) 3 METHYL 8 (PHENYLMETHOXY)IMIDAZO[1,2 A]PYRIDINE; 2,3 DIMETHYL 8 (PHENYLMETHOXY)IMIDAZO[1,2 A]PYRAZINE; 2,3 DIMETHYL 8 PHENETHYLIMIDAZO[1,2 A]PYRIDINE; 8 BENZYLOXY 2 METHYLIMIDAZO[1,2 A]PYRIDINE 3 ACETONITRILE; ANTIULCER AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; DOG; DRUG CONFORMATION; DRUG POTENCY; ENZYME ACTIVE SITE; HYPOTHETICAL ACTIVE SITE LATTICE; INTERMETHOD COMPARISON; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR MODEL; NONHUMAN; ORAL DRUG ADMINISTRATION; STOMACH SECRETION; STOMACH ULCER; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ULCER AGENTS; BINDING SITES; DOGS; ELECTROSTATICS; GASTRIC MUCOSA; H(+)-K(+)-EXCHANGING ATPASE; IMAGE PROCESSING, COMPUTER-ASSISTED; IMIDAZOLES; MODELS, CHEMICAL; MODELS, MOLECULAR; PROTEIN CONFORMATION; PYRIDINES;

EID: 0031059044     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950700s     Document Type: Article

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