-
1
-
-
3042762359
-
One tissue, two fates: molecular genetic events that underlie testis versus ovary development
-
This comprehensive and intelligent review summarizes a wealth of information on the genetic cascade and cellular events involved in gonadal sex determination and differentiation.
-
Brennan J., and Capel B. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 5 (2004) 509-521. This comprehensive and intelligent review summarizes a wealth of information on the genetic cascade and cellular events involved in gonadal sex determination and differentiation.
-
(2004)
Nat Rev Genet
, vol.5
, pp. 509-521
-
-
Brennan, J.1
Capel, B.2
-
2
-
-
11144329603
-
Signaling at the crossroads of gonad development
-
This excellent review summarizes information on signal transduction and cellular events in gonadal sex determination and differentiation.
-
Ross A.J., and Capel B. Signaling at the crossroads of gonad development. Trends Endocrinol Metab 16 (2005) 19-25. This excellent review summarizes information on signal transduction and cellular events in gonadal sex determination and differentiation.
-
(2005)
Trends Endocrinol Metab
, vol.16
, pp. 19-25
-
-
Ross, A.J.1
Capel, B.2
-
3
-
-
31344454595
-
Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals
-
Val P., and Swain A. Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals. Nat Clin Pract Urol 2 (2005) 616-627
-
(2005)
Nat Clin Pract Urol
, vol.2
, pp. 616-627
-
-
Val, P.1
Swain, A.2
-
4
-
-
12344333666
-
The pathway of femaleness: current knowledge on embryonic development of the ovary
-
Yao H.H. The pathway of femaleness: current knowledge on embryonic development of the ovary. Mol Cell Endocrinol 230 (2005) 87-93
-
(2005)
Mol Cell Endocrinol
, vol.230
, pp. 87-93
-
-
Yao, H.H.1
-
5
-
-
0141682318
-
Primordial germ cells in the mouse
-
McLaren A. Primordial germ cells in the mouse. Dev Biol 262 (2003) 1-5
-
(2003)
Dev Biol
, vol.262
, pp. 1-5
-
-
McLaren, A.1
-
6
-
-
4644299516
-
SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
-
This study investigates the identity of the cells expressing Sry and Sox9. SRY-positive cells were first observed in the gonad and not in the coelomic epithelium. The study demonstrates that, after the coelomic epithelial cells migrate into the gonad, there is first a decision to become interstitial or supporting cells, and then the transient expression of SRY in the latter determines their fate as Sertoli cells by upregulating Sox9.
-
Sekido R., Bar I., Narvaez V., Penny G., and Lovell-Badge R. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev Biol 274 (2004) 271-279. This study investigates the identity of the cells expressing Sry and Sox9. SRY-positive cells were first observed in the gonad and not in the coelomic epithelium. The study demonstrates that, after the coelomic epithelial cells migrate into the gonad, there is first a decision to become interstitial or supporting cells, and then the transient expression of SRY in the latter determines their fate as Sertoli cells by upregulating Sox9.
-
(2004)
Dev Biol
, vol.274
, pp. 271-279
-
-
Sekido, R.1
Bar, I.2
Narvaez, V.3
Penny, G.4
Lovell-Badge, R.5
-
7
-
-
12944324216
-
Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal
-
Bullejos M., and Koopman P. Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal. Dev Biol 278 (2005) 473-481
-
(2005)
Dev Biol
, vol.278
, pp. 473-481
-
-
Bullejos, M.1
Koopman, P.2
-
8
-
-
0038206950
-
Cell proliferation is necessary for the determination of male fate in the gonad
-
Schmahl J., and Capel B. Cell proliferation is necessary for the determination of male fate in the gonad. Dev Biol 258 (2003) 264-276
-
(2003)
Dev Biol
, vol.258
, pp. 264-276
-
-
Schmahl, J.1
Capel, B.2
-
9
-
-
4444294105
-
Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
-
Schmahl J., Kim Y., Colvin J.S., Ornitz D.M., and Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131 (2004) 3627-3636
-
(2004)
Development
, vol.131
, pp. 3627-3636
-
-
Schmahl, J.1
Kim, Y.2
Colvin, J.S.3
Ornitz, D.M.4
Capel, B.5
-
10
-
-
0344875027
-
Testis determination requires insulin receptor family function in mice
-
Nef S., Verma-Kurvari S., Merenmies J., Vassalli J.D., Efstratiadis A., Accili D., and Parada L.F. Testis determination requires insulin receptor family function in mice. Nature 426 (2003) 291-296
-
(2003)
Nature
, vol.426
, pp. 291-296
-
-
Nef, S.1
Verma-Kurvari, S.2
Merenmies, J.3
Vassalli, J.D.4
Efstratiadis, A.5
Accili, D.6
Parada, L.F.7
-
11
-
-
19944432874
-
Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice
-
Kidokoro T., Matoba S., Hiramatsu R., Fujisawa M., Kanai-Azuma M., Taya C., Kurohmaru M., Kawakami H., Hayashi Y., Kanai Y., and Yonekawa H. Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev Biol 278 (2005) 511-525
-
(2005)
Dev Biol
, vol.278
, pp. 511-525
-
-
Kidokoro, T.1
Matoba, S.2
Hiramatsu, R.3
Fujisawa, M.4
Kanai-Azuma, M.5
Taya, C.6
Kurohmaru, M.7
Kawakami, H.8
Hayashi, Y.9
Kanai, Y.10
Yonekawa, H.11
-
12
-
-
0029742909
-
Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
-
Morais da Silva S., Hacker A., Harley V., Goodfellow P., Swain A., and Lovell-Badge R. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 14 (1996) 62-68
-
(1996)
Nat Genet
, vol.14
, pp. 62-68
-
-
Morais da Silva, S.1
Hacker, A.2
Harley, V.3
Goodfellow, P.4
Swain, A.5
Lovell-Badge, R.6
-
13
-
-
0034050638
-
Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development
-
de Santa Barbara P., Moniot B., Poulat F., and Berta P. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 217 (2000) 293-298
-
(2000)
Dev Dyn
, vol.217
, pp. 293-298
-
-
de Santa Barbara, P.1
Moniot, B.2
Poulat, F.3
Berta, P.4
-
14
-
-
0023835679
-
Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX-XY chimaeric mouse testes
-
Burgoyne P.S., Buehr M., Koopman P., Rossant J., and McLaren A. Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX-XY chimaeric mouse testes. Development 102 (1988) 443-540
-
(1988)
Development
, vol.102
, pp. 443-540
-
-
Burgoyne, P.S.1
Buehr, M.2
Koopman, P.3
Rossant, J.4
McLaren, A.5
-
15
-
-
27744559963
-
Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination
-
This study shows that not all Sox9-expressing Sertoli cells have experienced Sry expression. The data presented in this report suggest a mechanism whereby Sry uses both a cell-autonomous mechanism and a PGD2-mediated signaling mechanism to stimulate expression of Sox9 and to induce the differentiation of Sertoli cells in vivo.
-
Wilhelm D., Martinson F., Bradford S., Wilson M.J., Combes A.N., Beverdam A., Bowles J., Mizusaki H., and Koopman P. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287 (2005) 111-124. This study shows that not all Sox9-expressing Sertoli cells have experienced Sry expression. The data presented in this report suggest a mechanism whereby Sry uses both a cell-autonomous mechanism and a PGD2-mediated signaling mechanism to stimulate expression of Sox9 and to induce the differentiation of Sertoli cells in vivo.
-
(2005)
Dev Biol
, vol.287
, pp. 111-124
-
-
Wilhelm, D.1
Martinson, F.2
Bradford, S.3
Wilson, M.J.4
Combes, A.N.5
Beverdam, A.6
Bowles, J.7
Mizusaki, H.8
Koopman, P.9
-
16
-
-
20044370153
-
Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation
-
Malki S., Nef S., Notarnicola C., Thevenet L., Gasca S., Mejean C., Berta P., Poulat F., and Boizet-Bonhoure B. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation. EMBO J 24 (2005) 1798-1809
-
(2005)
EMBO J
, vol.24
, pp. 1798-1809
-
-
Malki, S.1
Nef, S.2
Notarnicola, C.3
Thevenet, L.4
Gasca, S.5
Mejean, C.6
Berta, P.7
Poulat, F.8
Boizet-Bonhoure, B.9
-
17
-
-
27744466334
-
Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
-
Nef S., Schaad O., Stallings N.R., Cederroth C.R., Pitetti J.L., Schaer G., Malki S., Dubois-Dauphin M., Boizet-Bonhoure B., et al. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Dev Biol 287 (2005) 361-377
-
(2005)
Dev Biol
, vol.287
, pp. 361-377
-
-
Nef, S.1
Schaad, O.2
Stallings, N.R.3
Cederroth, C.R.4
Pitetti, J.L.5
Schaer, G.6
Malki, S.7
Dubois-Dauphin, M.8
Boizet-Bonhoure, B.9
-
18
-
-
31544470351
-
Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes
-
Beverdam A., and Koopman P. Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes. Hum Mol Genet 15 (2006) 417-431
-
(2006)
Hum Mol Genet
, vol.15
, pp. 417-431
-
-
Beverdam, A.1
Koopman, P.2
-
19
-
-
12344329357
-
Profiling gene expression during the differentiation and development of the murine embryonic gonad
-
Small C.L., Shima J.E., Uzumcu M., Skinner M.K., and Griswold M.D. Profiling gene expression during the differentiation and development of the murine embryonic gonad. Biol Reprod 72 (2005) 492-501
-
(2005)
Biol Reprod
, vol.72
, pp. 492-501
-
-
Small, C.L.1
Shima, J.E.2
Uzumcu, M.3
Skinner, M.K.4
Griswold, M.D.5
-
20
-
-
0035733723
-
A 11.7-kb deletion triggers intersexuality and polledness in goats
-
Pailhoux E., Vigier B., Chaffaux S., Servel N., Taourit S., Furet J.P., Fellous M., Grosclaude F., Cribiu E.P., Cotinot C., and Vaiman D. A 11.7-kb deletion triggers intersexuality and polledness in goats. Nat Genet 29 (2001) 453-458
-
(2001)
Nat Genet
, vol.29
, pp. 453-458
-
-
Pailhoux, E.1
Vigier, B.2
Chaffaux, S.3
Servel, N.4
Taourit, S.5
Furet, J.P.6
Fellous, M.7
Grosclaude, F.8
Cribiu, E.P.9
Cotinot, C.10
Vaiman, D.11
-
21
-
-
0035131812
-
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
-
Crisponi L., Deiana M., Loi A., Chiappe F., Uda M., Amati P., Bisceglia L., Zelante L., Nagaraja R., Porcu S., et al. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. Nat Genet 27 (2001) 159-166
-
(2001)
Nat Genet
, vol.27
, pp. 159-166
-
-
Crisponi, L.1
Deiana, M.2
Loi, A.3
Chiappe, F.4
Uda, M.5
Amati, P.6
Bisceglia, L.7
Zelante, L.8
Nagaraja, R.9
Porcu, S.10
-
22
-
-
2942750361
-
Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development
-
Uda M., Ottolenghi C., Crisponi L., Garcia J.E., Deiana M., Kimber W., Forabosco A., Cao A., Schlessinger D., and Pilia G. Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13 (2004) 1171-1181
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1171-1181
-
-
Uda, M.1
Ottolenghi, C.2
Crisponi, L.3
Garcia, J.E.4
Deiana, M.5
Kimber, W.6
Forabosco, A.7
Cao, A.8
Schlessinger, D.9
Pilia, G.10
-
23
-
-
26444511733
-
Foxl2 is required for commitment to ovary differentiation
-
Ottolenghi C., Omari S., Garcia-Ortiz J.E., Uda M., Crisponi L., Forabosco A., Pilia G., and Schlessinger D. Foxl2 is required for commitment to ovary differentiation. Hum Mol Genet 14 (2005) 2053-2062
-
(2005)
Hum Mol Genet
, vol.14
, pp. 2053-2062
-
-
Ottolenghi, C.1
Omari, S.2
Garcia-Ortiz, J.E.3
Uda, M.4
Crisponi, L.5
Forabosco, A.6
Pilia, G.7
Schlessinger, D.8
-
24
-
-
0025877323
-
Male development of chromosomally female mice transgenic for Sry
-
Koopman P., Gubbay J., Vivian N., Goodfellow P., and Lovell-Badge R. Male development of chromosomally female mice transgenic for Sry. Nature 351 (1991) 117-121
-
(1991)
Nature
, vol.351
, pp. 117-121
-
-
Koopman, P.1
Gubbay, J.2
Vivian, N.3
Goodfellow, P.4
Lovell-Badge, R.5
-
25
-
-
0033662409
-
A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse
-
Bishop C.E., Whitworth D.J., Qin Y., Agoulnik A.I., Agoulnik I.U., Harrison W.R., Behringer R.R., and Overbeek P.A. A transgenic insertion upstream of sox9 is associated with dominant XX sex reversal in the mouse. Nat Genet 26 (2000) 490-494
-
(2000)
Nat Genet
, vol.26
, pp. 490-494
-
-
Bishop, C.E.1
Whitworth, D.J.2
Qin, Y.3
Agoulnik, A.I.4
Agoulnik, I.U.5
Harrison, W.R.6
Behringer, R.R.7
Overbeek, P.A.8
-
26
-
-
0034931871
-
Sox9 induces testis development in XX transgenic mice
-
This study shows that transgenic expression of the Sox9 gene under the control of the Wt1 promoter in XX gonads leads to a complete XX sex-reversal.
-
Vidal V.P., Chaboissier M.C., de Rooij D.G., and Schedl A. Sox9 induces testis development in XX transgenic mice. Nat Genet 28 (2001) 216-217. This study shows that transgenic expression of the Sox9 gene under the control of the Wt1 promoter in XX gonads leads to a complete XX sex-reversal.
-
(2001)
Nat Genet
, vol.28
, pp. 216-217
-
-
Vidal, V.P.1
Chaboissier, M.C.2
de Rooij, D.G.3
Schedl, A.4
-
27
-
-
3042730829
-
Long-range activation of Sox9 in odd sex (Ods) mice
-
Qin Y., Kong L.K., Poirier C., Truong C., Overbeek P.A., and Bishop C.E. Long-range activation of Sox9 in odd sex (Ods) mice. Hum Mol Genet 13 (2004) 1213-1218
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1213-1218
-
-
Qin, Y.1
Kong, L.K.2
Poirier, C.3
Truong, C.4
Overbeek, P.A.5
Bishop, C.E.6
-
28
-
-
0033521967
-
Female development in mammals is regulated by Wnt-4 signalling
-
Vainio S., Heikkila M., Kispert A., Chin N., and McMahon A.P. Female development in mammals is regulated by Wnt-4 signalling. Nature 397 (1999) 405-409
-
(1999)
Nature
, vol.397
, pp. 405-409
-
-
Vainio, S.1
Heikkila, M.2
Kispert, A.3
Chin, N.4
McMahon, A.P.5
-
29
-
-
0031796372
-
Role of Ahch in gonadal development and gametogenesis
-
Yu R.N., Ito M., Saunders T.L., Camper S.A., and Jameson J.L. Role of Ahch in gonadal development and gametogenesis. Nat Genet 20 (1998) 353-357
-
(1998)
Nat Genet
, vol.20
, pp. 353-357
-
-
Yu, R.N.1
Ito, M.2
Saunders, T.L.3
Camper, S.A.4
Jameson, J.L.5
-
30
-
-
0041508536
-
Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad
-
Jeays-Ward K., Hoyle C., Brennan J., Dandonneau M., Alldus G., Capel B., and Swain A. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130 (2003) 3663-3670
-
(2003)
Development
, vol.130
, pp. 3663-3670
-
-
Jeays-Ward, K.1
Hoyle, C.2
Brennan, J.3
Dandonneau, M.4
Alldus, G.5
Capel, B.6
Swain, A.7
-
31
-
-
10044235047
-
Wnt4 is required for proper male as well as female sexual development
-
Jeays-Ward K., Dandonneau M., and Swain A. Wnt4 is required for proper male as well as female sexual development. Dev Biol 276 (2004) 431-440
-
(2004)
Dev Biol
, vol.276
, pp. 431-440
-
-
Jeays-Ward, K.1
Dandonneau, M.2
Swain, A.3
-
32
-
-
2442715158
-
Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
-
Yao H.H., Matzuk M.M., Jorgez C.J., Menke D.B., Page D.C., Swain A., and Capel B. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn 230 (2004) 210-215
-
(2004)
Dev Dyn
, vol.230
, pp. 210-215
-
-
Yao, H.H.1
Matzuk, M.M.2
Jorgez, C.J.3
Menke, D.B.4
Page, D.C.5
Swain, A.6
Capel, B.7
-
33
-
-
23844544781
-
The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action
-
Heikkila M., Prunskaite R., Naillat F., Itaranta P., Vuoristo J., Leppaluoto J., Peltoketo H., and Vainio S. The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action. Endocrinology 146 (2005) 4016-4023
-
(2005)
Endocrinology
, vol.146
, pp. 4016-4023
-
-
Heikkila, M.1
Prunskaite, R.2
Naillat, F.3
Itaranta, P.4
Vuoristo, J.5
Leppaluoto, J.6
Peltoketo, H.7
Vainio, S.8
-
34
-
-
4143139955
-
A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman
-
Biason-Lauber A., Konrad D., Navratil F., and Schoenle E.J. A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N Engl J Med 351 (2004) 792-798
-
(2004)
N Engl J Med
, vol.351
, pp. 792-798
-
-
Biason-Lauber, A.1
Konrad, D.2
Navratil, F.3
Schoenle, E.J.4
-
35
-
-
0016593481
-
Rat gonadal and ovarioan organogenesis with and without germ cells. An ultrastructural study
-
Merchant H. Rat gonadal and ovarioan organogenesis with and without germ cells. An ultrastructural study. Dev Biol 44 (1975) 1-21
-
(1975)
Dev Biol
, vol.44
, pp. 1-21
-
-
Merchant, H.1
|