메뉴 건너뛰기




Volumn 16, Issue 3, 2006, Pages 289-292

Sex determination and sex reversal

Author keywords

[No Author keywords available]

Indexed keywords

GENE MUTATION; GENETIC TRANSCRIPTION; GENETICS; GONAD; GONADAL DYSGENESIS; HETEROZYGOSITY; HORMONE SYNTHESIS; HUMAN; KARYOTYPE 46,XX; KARYOTYPE 46,XY; MAMMAL; NONHUMAN; ORGANOGENESIS; OVARY DEVELOPMENT; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SEX CHROMOSOME; SEX DETERMINATION; SEX TRANSFORMATION;

EID: 33646521304     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gde.2006.04.014     Document Type: Review
Times cited : (35)

References (35)
  • 1
    • 3042762359 scopus 로고    scopus 로고
    • One tissue, two fates: molecular genetic events that underlie testis versus ovary development
    • This comprehensive and intelligent review summarizes a wealth of information on the genetic cascade and cellular events involved in gonadal sex determination and differentiation.
    • Brennan J., and Capel B. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat Rev Genet 5 (2004) 509-521. This comprehensive and intelligent review summarizes a wealth of information on the genetic cascade and cellular events involved in gonadal sex determination and differentiation.
    • (2004) Nat Rev Genet , vol.5 , pp. 509-521
    • Brennan, J.1    Capel, B.2
  • 2
    • 11144329603 scopus 로고    scopus 로고
    • Signaling at the crossroads of gonad development
    • This excellent review summarizes information on signal transduction and cellular events in gonadal sex determination and differentiation.
    • Ross A.J., and Capel B. Signaling at the crossroads of gonad development. Trends Endocrinol Metab 16 (2005) 19-25. This excellent review summarizes information on signal transduction and cellular events in gonadal sex determination and differentiation.
    • (2005) Trends Endocrinol Metab , vol.16 , pp. 19-25
    • Ross, A.J.1    Capel, B.2
  • 3
    • 31344454595 scopus 로고    scopus 로고
    • Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals
    • Val P., and Swain A. Mechanisms of disease: normal and abnormal gonadal development and sex determination in mammals. Nat Clin Pract Urol 2 (2005) 616-627
    • (2005) Nat Clin Pract Urol , vol.2 , pp. 616-627
    • Val, P.1    Swain, A.2
  • 4
    • 12344333666 scopus 로고    scopus 로고
    • The pathway of femaleness: current knowledge on embryonic development of the ovary
    • Yao H.H. The pathway of femaleness: current knowledge on embryonic development of the ovary. Mol Cell Endocrinol 230 (2005) 87-93
    • (2005) Mol Cell Endocrinol , vol.230 , pp. 87-93
    • Yao, H.H.1
  • 5
    • 0141682318 scopus 로고    scopus 로고
    • Primordial germ cells in the mouse
    • McLaren A. Primordial germ cells in the mouse. Dev Biol 262 (2003) 1-5
    • (2003) Dev Biol , vol.262 , pp. 1-5
    • McLaren, A.1
  • 6
    • 4644299516 scopus 로고    scopus 로고
    • SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    • This study investigates the identity of the cells expressing Sry and Sox9. SRY-positive cells were first observed in the gonad and not in the coelomic epithelium. The study demonstrates that, after the coelomic epithelial cells migrate into the gonad, there is first a decision to become interstitial or supporting cells, and then the transient expression of SRY in the latter determines their fate as Sertoli cells by upregulating Sox9.
    • Sekido R., Bar I., Narvaez V., Penny G., and Lovell-Badge R. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev Biol 274 (2004) 271-279. This study investigates the identity of the cells expressing Sry and Sox9. SRY-positive cells were first observed in the gonad and not in the coelomic epithelium. The study demonstrates that, after the coelomic epithelial cells migrate into the gonad, there is first a decision to become interstitial or supporting cells, and then the transient expression of SRY in the latter determines their fate as Sertoli cells by upregulating Sox9.
    • (2004) Dev Biol , vol.274 , pp. 271-279
    • Sekido, R.1    Bar, I.2    Narvaez, V.3    Penny, G.4    Lovell-Badge, R.5
  • 7
    • 12944324216 scopus 로고    scopus 로고
    • Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal
    • Bullejos M., and Koopman P. Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal. Dev Biol 278 (2005) 473-481
    • (2005) Dev Biol , vol.278 , pp. 473-481
    • Bullejos, M.1    Koopman, P.2
  • 8
    • 0038206950 scopus 로고    scopus 로고
    • Cell proliferation is necessary for the determination of male fate in the gonad
    • Schmahl J., and Capel B. Cell proliferation is necessary for the determination of male fate in the gonad. Dev Biol 258 (2003) 264-276
    • (2003) Dev Biol , vol.258 , pp. 264-276
    • Schmahl, J.1    Capel, B.2
  • 9
    • 4444294105 scopus 로고    scopus 로고
    • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    • Schmahl J., Kim Y., Colvin J.S., Ornitz D.M., and Capel B. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. Development 131 (2004) 3627-3636
    • (2004) Development , vol.131 , pp. 3627-3636
    • Schmahl, J.1    Kim, Y.2    Colvin, J.S.3    Ornitz, D.M.4    Capel, B.5
  • 12
    • 0029742909 scopus 로고    scopus 로고
    • Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
    • Morais da Silva S., Hacker A., Harley V., Goodfellow P., Swain A., and Lovell-Badge R. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds. Nat Genet 14 (1996) 62-68
    • (1996) Nat Genet , vol.14 , pp. 62-68
    • Morais da Silva, S.1    Hacker, A.2    Harley, V.3    Goodfellow, P.4    Swain, A.5    Lovell-Badge, R.6
  • 13
    • 0034050638 scopus 로고    scopus 로고
    • Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development
    • de Santa Barbara P., Moniot B., Poulat F., and Berta P. Expression and subcellular localization of SF-1, SOX9, WT1, and AMH proteins during early human testicular development. Dev Dyn 217 (2000) 293-298
    • (2000) Dev Dyn , vol.217 , pp. 293-298
    • de Santa Barbara, P.1    Moniot, B.2    Poulat, F.3    Berta, P.4
  • 14
    • 0023835679 scopus 로고
    • Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX-XY chimaeric mouse testes
    • Burgoyne P.S., Buehr M., Koopman P., Rossant J., and McLaren A. Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX-XY chimaeric mouse testes. Development 102 (1988) 443-540
    • (1988) Development , vol.102 , pp. 443-540
    • Burgoyne, P.S.1    Buehr, M.2    Koopman, P.3    Rossant, J.4    McLaren, A.5
  • 15
    • 27744559963 scopus 로고    scopus 로고
    • Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination
    • This study shows that not all Sox9-expressing Sertoli cells have experienced Sry expression. The data presented in this report suggest a mechanism whereby Sry uses both a cell-autonomous mechanism and a PGD2-mediated signaling mechanism to stimulate expression of Sox9 and to induce the differentiation of Sertoli cells in vivo.
    • Wilhelm D., Martinson F., Bradford S., Wilson M.J., Combes A.N., Beverdam A., Bowles J., Mizusaki H., and Koopman P. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol 287 (2005) 111-124. This study shows that not all Sox9-expressing Sertoli cells have experienced Sry expression. The data presented in this report suggest a mechanism whereby Sry uses both a cell-autonomous mechanism and a PGD2-mediated signaling mechanism to stimulate expression of Sox9 and to induce the differentiation of Sertoli cells in vivo.
    • (2005) Dev Biol , vol.287 , pp. 111-124
    • Wilhelm, D.1    Martinson, F.2    Bradford, S.3    Wilson, M.J.4    Combes, A.N.5    Beverdam, A.6    Bowles, J.7    Mizusaki, H.8    Koopman, P.9
  • 18
    • 31544470351 scopus 로고    scopus 로고
    • Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes
    • Beverdam A., and Koopman P. Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes. Hum Mol Genet 15 (2006) 417-431
    • (2006) Hum Mol Genet , vol.15 , pp. 417-431
    • Beverdam, A.1    Koopman, P.2
  • 19
    • 12344329357 scopus 로고    scopus 로고
    • Profiling gene expression during the differentiation and development of the murine embryonic gonad
    • Small C.L., Shima J.E., Uzumcu M., Skinner M.K., and Griswold M.D. Profiling gene expression during the differentiation and development of the murine embryonic gonad. Biol Reprod 72 (2005) 492-501
    • (2005) Biol Reprod , vol.72 , pp. 492-501
    • Small, C.L.1    Shima, J.E.2    Uzumcu, M.3    Skinner, M.K.4    Griswold, M.D.5
  • 24
    • 0025877323 scopus 로고
    • Male development of chromosomally female mice transgenic for Sry
    • Koopman P., Gubbay J., Vivian N., Goodfellow P., and Lovell-Badge R. Male development of chromosomally female mice transgenic for Sry. Nature 351 (1991) 117-121
    • (1991) Nature , vol.351 , pp. 117-121
    • Koopman, P.1    Gubbay, J.2    Vivian, N.3    Goodfellow, P.4    Lovell-Badge, R.5
  • 26
    • 0034931871 scopus 로고    scopus 로고
    • Sox9 induces testis development in XX transgenic mice
    • This study shows that transgenic expression of the Sox9 gene under the control of the Wt1 promoter in XX gonads leads to a complete XX sex-reversal.
    • Vidal V.P., Chaboissier M.C., de Rooij D.G., and Schedl A. Sox9 induces testis development in XX transgenic mice. Nat Genet 28 (2001) 216-217. This study shows that transgenic expression of the Sox9 gene under the control of the Wt1 promoter in XX gonads leads to a complete XX sex-reversal.
    • (2001) Nat Genet , vol.28 , pp. 216-217
    • Vidal, V.P.1    Chaboissier, M.C.2    de Rooij, D.G.3    Schedl, A.4
  • 28
    • 0033521967 scopus 로고    scopus 로고
    • Female development in mammals is regulated by Wnt-4 signalling
    • Vainio S., Heikkila M., Kispert A., Chin N., and McMahon A.P. Female development in mammals is regulated by Wnt-4 signalling. Nature 397 (1999) 405-409
    • (1999) Nature , vol.397 , pp. 405-409
    • Vainio, S.1    Heikkila, M.2    Kispert, A.3    Chin, N.4    McMahon, A.P.5
  • 30
    • 0041508536 scopus 로고    scopus 로고
    • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad
    • Jeays-Ward K., Hoyle C., Brennan J., Dandonneau M., Alldus G., Capel B., and Swain A. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130 (2003) 3663-3670
    • (2003) Development , vol.130 , pp. 3663-3670
    • Jeays-Ward, K.1    Hoyle, C.2    Brennan, J.3    Dandonneau, M.4    Alldus, G.5    Capel, B.6    Swain, A.7
  • 31
    • 10044235047 scopus 로고    scopus 로고
    • Wnt4 is required for proper male as well as female sexual development
    • Jeays-Ward K., Dandonneau M., and Swain A. Wnt4 is required for proper male as well as female sexual development. Dev Biol 276 (2004) 431-440
    • (2004) Dev Biol , vol.276 , pp. 431-440
    • Jeays-Ward, K.1    Dandonneau, M.2    Swain, A.3
  • 33
    • 23844544781 scopus 로고    scopus 로고
    • The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action
    • Heikkila M., Prunskaite R., Naillat F., Itaranta P., Vuoristo J., Leppaluoto J., Peltoketo H., and Vainio S. The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action. Endocrinology 146 (2005) 4016-4023
    • (2005) Endocrinology , vol.146 , pp. 4016-4023
    • Heikkila, M.1    Prunskaite, R.2    Naillat, F.3    Itaranta, P.4    Vuoristo, J.5    Leppaluoto, J.6    Peltoketo, H.7    Vainio, S.8
  • 34
    • 4143139955 scopus 로고    scopus 로고
    • A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman
    • Biason-Lauber A., Konrad D., Navratil F., and Schoenle E.J. A WNT4 mutation associated with Müllerian-duct regression and virilization in a 46,XX woman. N Engl J Med 351 (2004) 792-798
    • (2004) N Engl J Med , vol.351 , pp. 792-798
    • Biason-Lauber, A.1    Konrad, D.2    Navratil, F.3    Schoenle, E.J.4
  • 35
    • 0016593481 scopus 로고
    • Rat gonadal and ovarioan organogenesis with and without germ cells. An ultrastructural study
    • Merchant H. Rat gonadal and ovarioan organogenesis with and without germ cells. An ultrastructural study. Dev Biol 44 (1975) 1-21
    • (1975) Dev Biol , vol.44 , pp. 1-21
    • Merchant, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.