Tetrahydrogestrinone is a potent but unselective binding steroid and affects glucocorticoid signalling in the liver

Toxicology Letters

Volumn 164, Issue 1, 2006, Pages 16-23

  Friedel, A ^a   Geyer, H ^c   Kamber, M ^d   Laudenbach Leschowsky, U ^a   Schanzer W ^c   Thevis, M ^c   Vollmer, G ^b   Zierau, O ^b   Diel, P ^a  

^a Institute of Cardiovascular Research and Sports Medicine   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^d Swiss Federal Institute of Sport   (Switzerland)

Author keywords

Anabolic steroid; Androgen; Doping; Glucocorticoid; Liver; Mineralocorticoid; Progestrone receptor; Tetrahydrogestrinone

Indexed keywords

ANABOLIC AGENT; ANDROGEN RECEPTOR; ANDROSTANOLONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR; PROGESTERONE RECEPTOR; TESTOSTERONE PROPIONATE; TETRAHYDROGESTRINONE; TYROSINE AMINOTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE EXPRESSION; LEVATOR ANI MUSCLE; LIVER; MALE; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROSTATE; RAT; SEMINAL VESICLE; SIGNAL TRANSDUCTION; STEROID BINDING;

ANABOLIC AGENTS; ANIMALS; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; GESTRINONE; HUMANS; LIVER; MALE; MOLECULAR STRUCTURE; MUSCLE, SMOOTH; ORCHIECTOMY; ORGAN SIZE; PROSTATE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; RECEPTORS, GLUCOCORTICOID; SEMINAL VESICLES; SIGNAL TRANSDUCTION; YEASTS;

ANIMALIA;

EID: 33646499421     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.11.006     Document Type: Article

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