Effect of vagus nerve stimulation on creativity and cognitive flexibility

Epilepsy and Behavior

Volumn 8, Issue 4, 2006, Pages 720-725

  Ghacibeh, Georges A ^a   Shenker, Joel I ^a   Shenal, Brian ^a,b   Uthman, Basim M ^a,b   Heilman, Kenneth M ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Central adrenergic pathways; Cognitive flexibility; Creativity; Locus coeruleus; Vagus nerve stimulation (VNS)

Indexed keywords

ALPRAZOLAM; CARBAMAZEPINE; CLORAZEPATE; ETIRACETAM; LAMOTRIGINE; PHENYTOIN; PREGABALIN; TIAGABINE; TOPIRAMATE; ZONISAMIDE;

ADRENERGIC SYSTEM; ADULT; ARTICLE; BRAIN DISEASE; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CREATIVITY; FEMALE; HUMAN; INTRACTABLE EPILEPSY; LEARNING; LOCUS CERULEUS; MALE; MEMORY; MEMORY CONSOLIDATION; MENTAL TASK; MINI MENTAL STATE EXAMINATION; PROBLEM SOLVING; SENSORY STIMULATION; SIGNAL NOISE RATIO; TASK PERFORMANCE; VAGUS NERVE STIMULATION;

ADULT; COGNITION; CREATIVENESS; ELECTRIC STIMULATION THERAPY; EPILEPSIES, PARTIAL; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; PSYCHOLOGICAL TESTS; VAGUS NERVE;

EID: 33646498320     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2006.03.008     Document Type: Article

References (34)

1. Bronowski J. Science and human values (1972), Harper and Row, New York
2. Heilman K.M., Nadeau S.E., and Beversdorf D.O. Creative innovation: possible brain mechanisms. NeuroCase 9 (2003) 369-379
3. James W. The principles of psychology (1890), Hold, New York
4. Beversdorf D.Q., Hughes J.D., Steinberg B.A., Lewis L.D., and Heilman K.M. Noradrenergic modulation of cognitive flexibility in problem solving. NeuroReport 10 (1999) 2763-2767
5. Martindale C., and Greenough J. The differential effect of increased arousal on creative and intellectual performance. J Genet Psychol 123 (1973) 329-335
6. Post F. Creativity and psychopathology. A study of 291 world-famous men. Br J Psychiatry 165 (1994) 22-34
7. Poldinger W. The relation between depression and art. Psychopathology 19 S2 (1986) 263-268
8. Richards R., Kinney D.K., Lunde I., Benet M., and Merzel A.P. Creativity in manic-depressives, cyclothymes, their normal relatives, and control subjects. J Abnorm Psychol 97 (1988) 281-288
9. The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology 1995;45:224-30.
10. Rush A., George M., Sackeim H., et al. Vagus nerve stimulation for treatment-resistant depressions: a multicenter study. Biol Psychiatry 47 (2000) 76-86
11. Clark K.B., Naritoku D.K., Smith D.C., Browning R.A., and Jensen R.A. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat Neurosci 2 (1999) 94-98
12. Krahl S.E., Clark K.B., Smith D.C., and Browning R.A. Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia 39 (1998) 709-714
13. Krahl S.E., Browning R.A., Clark K.B., and Smith D.C. Possible mechanism of the seizure attenuating effects of VNS. Soc Neurosci Abstr 20 (1994) 1453
14. Welsh K.A., and Gold P.E. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection on amygdaloid kindling. Behav Neural Biol 40 (1984) 179-185
15. Goff K., and Torrance E.P. Abbreviated Torrance test for adults manual (2002), Scholastic Testing Service, Bensenville, IL
16. Brandt J. The Hopkins Verbal Learning Test: development of a new memory test with six equivalent forms. Clin Neuropsychol 5 (1991) 125-142
17. Ghacibeh GA, Shenker J, Shenal BI, Uthman BM, Heilman KM. The influence of vagus nerve stimulation on memory. Cogn Behav Neurol, in press.
18. Sackeim H.A., Keilp J.G., Rush A.J., et al. The effects of vagus nerve stimulation on cognitive performance in patients with treatment-resistant depression. Neuropsychiatry Neuropsychol Behav Neurol 14 (2001) 53-62
19. Dodrill C.B., and George M.L. Effects of vagal nerve stimulation on cognition and quality of life in epilepsy. Epilepsy Behav 2 (2001) 46-53
20. George M.S. Vagus nerve stimulation: a tool for brain research and therapy. Biol Psychiatry 47 (2000) 287-295
21. Jones B.E. Noradrenergic locus coeruleus neurons: their distant connections and their relationship to neighboring neurons of the central gray and reticular formation. Prog Brain Res 88 (1991) 15-30
22. Gioroba Z.J., and Blessing W.W. Fos-containing neurons in medulla and pons after unilateral stimulation of the afferent abdominal vagus in conscious rabbits. Neuroscience 59 (1994) 851-858
23. Naritoky D.K., Terry W.J., and Helfert R.H. Regional induction of fos immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Res 22 (1995) 53-62
24. Hasselmo M.E., Linster C., Patil M., Ma D., and Cekic M. Noradrenergic suppression of synaptic transmission may influence cortical signal-to-noise ratio. J Neurophysiol 77 (1997) 3326-3339
25. Aston-Jones G., Shipley M.T., Chouber G., et al. Afferent regulation of locus coeruleus neurons: anatomy, physiology and pharmacology. Prog Brain Res 88 (1991) 47-75
26. Hasselmo M.E. Neuromodulation and cortical function: modeling the physiological basis of behavior. Behav Brain Res 67 (1995) 1-27
27. Waterhouse B.D., and Woodward D. Interaction of norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in rat. Exp Neurol 7 (1980) 11-34
28. Madar Y., and Segal M. The functional role of the noradrenergic system in the visual cortex: activation of the noradrenergic pathway. Exp Brain Res 41 (1980) 814
29. Edeline J.M., and Sara S.J. Sharpening frequency receptive fields of auditory cortex neurons by idiozoxan-induced release of norepinephrine [abstract]. Soc Neurosci Abstr 19 (1993) 1933
30. Krahl S.E., Senanayake D., and Handforth A. Seizure suppression by systemic epinephrine is mediated by the vagus nerve. Epilepsy Res 381 (2000) 171-175
31. Rogawski M.A., and Aghajanian C.K. Modulation of lateral geniculate neuron excitability by noradrenaline microinontophoresis or locus coeruleus stimulation. Nature 287 (1980) 731-734
32. McCormick D.A. Cholinergic and noradrenergic modulation of thalamocortical processin. Trends Neurosci 129 (1989) 215-221
33. Kischka U., Kammer T.H., Maier S., Weixbrod M., Thimm M., and Spitzer M. Dopaminergic modulation of semantic network activation. Neuropsychologia 34 (1996) 1107-1113
34. Beversdorf D.Q., White D.M., Chever D.C., Hughes J.D., and Bornstein R.A. Central beta-adrenergic modulation of cognitive flexibility. NeuroReport 13 (2002) 2505-2507