Seizure suppression by systemic epinephrine is mediated by the vagus nerve

Epilepsy Research

Volumn 38, Issue 2-3, 2000, Pages 171-175

  Krahl, Scott E ^a,b   Senanayake, Shayani S ^a   Handforth, Adrian ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adrenaline; Anticonvulsant; Epilepsy; Pentylenetetrazol; Vagus nerve

Indexed keywords

ADRENALIN; PENTETRAZOLE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; VAGOTOMY; VAGUS NERVE;

AFFERENT PATHWAYS; ANIMALS; ANTICONVULSANTS; CONVULSANTS; EPINEPHRINE; FEMALE; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; SEIZURES; VAGOTOMY; VAGUS NERVE;

EID: 0033992134     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(99)00089-3     Document Type: Article

References (14)

1. Axelrod J., Weil-Malherbe H., Tomchick R. The physiological disposition of H3-epinephrine and its metabolite metanephrine. J. Pharmacol. Exp. Ther. 127:1959;251-256.
2. Clark K.B., Krahl S.E., Smith D.C., Jensen R.A. Post-training unilateral vagal stimulation enhances retention performance in the rat. Neurobiol. Learn. Mem. 63:1995;213-216.
3. Clark K.B., Naritoku D.K., Smith D.C., Browning R.A., Jensen R.A. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nature Neurosci. 2:1999;94-98.
4. Drugan R.C., McIntyre T.D., Alpern H.P., Maier S.F. Coping and seizure susceptibility: control over shock protects against bicuculline-induced seizures. Brain Res. 342:1985;9-17.
5. Gold P.E., McCarty R., Sternberg D.B. Peripheral catecholamines and memory modulation. Ajmone Marsan C., Matthies H. Neuronal Plasticity and Memory Formation. 1982;327-338 Raven Press, New York.
6. Gold P.E., McGaugh J.L. Effect of recent footshock on brain seizures and behavioral convulsions induced by electrical stimulation of the brain. Behav. Biol. 7:1972;421-426.
7. Handforth A., DeGiorgio C.M., Schachter S.C., Uthman B.M., Naritoku D.K., Tecoma E.S. et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurol. 51:1998;48-55.
8. Kadar T., Pesti A., Penke B., Toth G., Zarandi M., Telegdy G. Structure-activity and dose-effect relationships of the antagonism of picrotoxin-induced seizures by cholecystokinin, fragments and analogues of cholecystokinin in mice. Neuropharmacology. 22:1983;1223-1229.
9. Welsh K.A., Gold P.E. Attenuation of epileptogenesis: proactive effect of a single epinephrine injection on amygdaloid kindling. Behav. Neurol. Biol. 40:1984;179-185.
10. Welsh K.A., Gold P.E. Epinephrine proactive retardation of amygdala-kindled epileptogenesis. Behav. Neurosci. 100:1986;236-245.
11. Williams C.L., Jensen R.A. Vagal afferents: a possible mechanism for the modulation of memory by peripherally acting agents. Frederickson R.C.A., McGaugh J.L., Felton D.L. Peripheral Signaling of the Brain: Role of Neural-Immune Interactions, Learning and Memory. 1991;467-472 Hogrefe and Huber, Toronto.
12. Williams C.L., McGaugh J.L. Reversible lesions of the nucleus of the solitary tract attenuate the memory-modulating effects of posttraining epinephrine. Behav. Neurosci. 107:1993;955-962.
13. Woodbury D.M., Woodbury J.W. Effects of vagal stimulation on experimentally induced seizures in rats. Epilepsia. 31(S2):1990;S7-S19.
14. Woodbury J.W., Woodbury D.M. Vagal stimulation reduces the severity of maximal electroshock seizures in intact rats: use of a cuff electrode for stimulating and recording. Pacing Clin. Electrophysiol. 14:1991;94-107.