Effect of folic acid supplementation on the efficacy of metholrexate treatment in rheumatoid arthritis: Comment on the article by Khaanna et al. [5]

Arthritis and Rheumatism

Volumn 54, Issue 5, 2006, Pages 1708-1709

  Morgan, Sarah L ^a   Baggott, Joseph E ^a   Alarcón, Graciela S ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; LEFLUNOMIDE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

CEREAL; CLINICAL TRIAL; DISEASE DURATION; DRUG EFFICACY; GRAIN; HUMAN; LETTER; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; VITAMIN SUPPLEMENTATION;

ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DRUG INTERACTIONS; FOLIC ACID; HEMATINICS; HUMANS; METHOTREXATE;

EID: 33646485533     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21801     Document Type: Letter

References (6)

1. Strand V, Cohen S, Schiff M, Weaver A, Fleischman R, Cannon G, et al, and the Leflunomide Rheumatoid Arthritis Investigators Group. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med 1999;159:2542-50.
2. Emery P, Breedveld FC, Lemmel EM, Rosenberg R, Loew-Friedrich I. A phase III, randomized double-blind study of leflunomide versus methotrexate in rheumatoid arthritis. Proceedings of the XIV EULAR Congress; 1999; Glasgow, Scotland.
3. Emery P, Breedveld FC, Lemmel EM, Kaltwasser JP, Dawes PT, Gomor B, et al. A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis. Rheumatology (Oxford) 2000;39:655-65.
4. Strand V, Morgan SL, Baggott JE, Alarcon GS. Folic acid supplementation and methotrexate efficacy: comment on articles by Schiff, Emery et al, and others [letter]. Arthritis Rheum 2000;43:2615-6.
5. Khanna D, Park GS, Paulus HE, Simpson KM, Elashoff D, Cohen SB, et al. Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies. Arthritis Rheum 2005;52:3030-8.
6. Morgan SL, Baggott JE, Vaughn WH, Austin JS, Veitch TA, Lee JY, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis: a double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41.